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1.发明授权公开(公告)号：US07294344B2
公开(公告)日：2007-11-13
申请号：US10443308
申请日：2003-05-22
申请人： Yasutaka Igari , Akira Saikawa , Yoshiyuki Inada , Shigeru Kamei
发明人： Yasutaka Igari , Akira Saikawa , Yoshiyuki Inada , Shigeru Kamei
CPC分类号： A61K31/00 , A61K9/1611 , A61K9/1647 , A61K31/4178 , A61K31/4184 , Y10S514/965
摘要： The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly stable and active and shows angiotensin II antagonistic activity while maintaining circadian rhythm of blood pressure for a long time.
摘要翻译： 本发明提供一种缓释制剂，其包含具有血管紧张素II拮抗作用的化合物，其前药或其盐，以及可生物降解的聚合物，如果需要，提供多价金属，并且其具有高度稳定和活性的 显示血管紧张素II拮抗活性，同时保持血压的昼夜节律长时间。
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2.发明授权公开(公告)号：US06589547B1
公开(公告)日：2003-07-08
申请号：US09601986
申请日：2000-08-09
申请人： Yasutaka Igari , Akira Saikawa , Yoshiyuki Inada , Shigeru Kamei
发明人： Yasutaka Igari , Akira Saikawa , Yoshiyuki Inada , Shigeru Kamei
IPC分类号： A61K916
CPC分类号： A61K31/00 , A61K9/1611 , A61K9/1647 , A61K31/4178 , A61K31/4184 , Y10S514/965
摘要： The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly stable and active and shows angiotensin II antagonistic activity while maintaining circadian rhythm of blood pressure for a long time.
摘要翻译： 本发明提供一种缓释制剂，其包含具有血管紧张素II拮抗作用的化合物，其前药或其盐，以及可生物降解的聚合物，如果需要，提供多价金属，并且其具有高度稳定和活性的 显示血管紧张素II拮抗活性，同时保持血压的昼夜节律长时间。
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公开(公告)号：US5665394A
公开(公告)日：1997-09-09
申请号：US723152
申请日：1996-09-30
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
摘要翻译： 本发明涉及用于缓释制剂的基质，其包含在直链聚酯的末端羧基上形成的酯，其基本上由α-羟基单羧酸组成。 基质对光，热，水分，着色等均稳定，毒性低。 通过使用本发明的酯制备的缓释制剂在延长的时间内提供稳定的药物释放，确保持续的稳定的效果。 此外，缓释制剂在施用后不显示过量的药物释放。
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公开(公告)号：US5594091A
公开(公告)日：1997-01-14
申请号：US391699
申请日：1995-02-21
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
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5.发明授权公开(公告)号：US06740634B1
公开(公告)日：2004-05-25
申请号：US09582926
申请日：2000-07-06
申请人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
发明人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
IPC分类号： A61K3800
CPC分类号： A61K47/34 , A61K9/1647 , A61K38/09 , A61K47/54 , A61K47/542
摘要： A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition.
摘要翻译： 含有生物活性物质的羟基萘甲酸盐和可生物降解的聚合物的缓释组合物，其生产方法和含有所述缓释组合物的药物组合物。
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6.发明授权公开(公告)号：US07388032B2
公开(公告)日：2008-06-17
申请号：US10799320
申请日：2004-03-12
申请人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
发明人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
IPC分类号： A61K47/00
CPC分类号： A61K47/34 , A61K9/1647 , A61K38/09 , A61K47/54 , A61K47/542
摘要： A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition.
摘要翻译： 含有生物活性物质的羟基萘甲酸盐和可生物降解的聚合物的缓释组合物，其生产方法和含有所述缓释组合物的药物组合物。
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7.发明申请公开(公告)号：US20050025826A1
公开(公告)日：2005-02-03
申请号：US10799320
申请日：2004-03-12
申请人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
发明人： Akira Saikawa , Yasutaka Igari , Yoshio Hata , Kazumichi Yamamoto
IPC分类号： A61K9/22 , A61K9/16 , A61K9/52 , A61K38/09 , A61K47/12 , A61K47/30 , A61K47/34 , A61K47/48 , A61K9/00 , A61K9/50 , A61K31/19
CPC分类号： A61K47/34 , A61K9/1647 , A61K38/09 , A61K47/54 , A61K47/542
摘要： A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition.
摘要翻译： 含有生物活性物质的羟基萘甲酸盐和可生物降解的聚合物的缓释组合物，其生产方法和含有所述缓释组合物的药物组合物。
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