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公开(公告)号:US20080112917A1
公开(公告)日:2008-05-15
申请号:US10561394
申请日:2004-06-17
IPC分类号: A61K31/787 , C07F9/02 , A61K31/685
CPC分类号: A61K31/132 , A61K9/1272 , A61K38/47 , A61K39/39 , A61K48/0041 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , C07C271/20 , C12N15/88 , A61K2300/00
摘要: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same.In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.
摘要翻译: 本发明涉及新型鞘脂 - 多烷基胺缀合物,其制备方法和包含其的药物组合物。 特别地,本发明涉及神经酰胺基聚烷基胺共轭物及其作为捕获剂的用途。 优选的神经酰胺多烷基胺缀合物是神经酰胺精胺缀合物,更优选N-棕榈酰基D-赤藓糖鞘糖醇-1-氨基甲酰基精胺。
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公开(公告)号:US07771711B2
公开(公告)日:2010-08-10
申请号:US10561394
申请日:2004-06-17
IPC分类号: A61K31/74
CPC分类号: A61K31/132 , A61K9/1272 , A61K38/47 , A61K39/39 , A61K48/0041 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , C07C271/20 , C12N15/88 , A61K2300/00
摘要: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.
摘要翻译: 本发明涉及新型鞘脂 - 多烷基胺缀合物,其制备方法和包含其的药物组合物。 特别地,本发明涉及神经酰胺基聚烷基胺共轭物及其作为捕获剂的用途。 优选的神经酰胺多烷基胺缀合物是神经酰胺精胺缀合物,更优选N-棕榈酰基D-赤藓糖鞘糖醇-1-氨基甲酰基精胺。
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3.
公开(公告)号:US20070282120A1
公开(公告)日:2007-12-06
申请号:US10586056
申请日:2005-01-13
申请人: Elimelech Rochlin , Jean Hildesheim , Alisa Berlin
发明人: Elimelech Rochlin , Jean Hildesheim , Alisa Berlin
IPC分类号: C07F9/6584 , C07F9/113
CPC分类号: C07F9/65844 , C07F9/113
摘要: Novel cyclic and acyclic oxazaphospholanes are described, as well as their use in the synthesis of sphingomyelin and sphingomyelin analogous. The production of synthetic sphingomyelins is also described. 2S, 3R stereoisomers of oxazaphospholanes and sphingomyelins, and synthetic methods for their preparation are described.
摘要翻译: 描述了新的环状和无环氧氮杂磷杂环己烷,以及它们在鞘磷脂和鞘磷脂合成中的应用。 还描述了合成鞘磷脂的生产。 描述了oxazaphospholanes和鞘磷脂的2S,3R立体异构体及其制备的合成方法。
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4.
公开(公告)号:US07687652B2
公开(公告)日:2010-03-30
申请号:US10586056
申请日:2005-01-13
申请人: Elimelech Rochlin , Jean Hildesheim , Alisa Berlin
发明人: Elimelech Rochlin , Jean Hildesheim , Alisa Berlin
IPC分类号: C07F9/02
CPC分类号: C07F9/65844 , C07F9/113
摘要: Novel cyclic and acyclic oxazaphospholanes are described, as well as their use in the synthesis of sphingomyelin and sphingomyelin analogous. The production of synthetic sphingomyelins is also described. 2S, 3R stereoisomers of oxazaphospholanes and sphingomyelins, and synthetic methods for their preparation are described.
摘要翻译: 描述了新的环状和无环氧氮杂磷杂环己烷,以及它们在鞘磷脂和鞘磷脂合成中的应用。 还描述了合成鞘磷脂的生产。 描述了oxazaphospholanes和鞘磷脂的2S,3R立体异构体及其制备的合成方法。
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5.
公开(公告)号:US06469148B1
公开(公告)日:2002-10-22
申请号:US09568387
申请日:2000-05-10
申请人: Elimelech Rochlin
发明人: Elimelech Rochlin
IPC分类号: C07H1500
CPC分类号: C07H9/04 , C07B2200/07 , C07C213/00 , C07C231/08 , C07C231/18 , C07H15/10 , C07C215/06 , C07C215/24 , C07C233/18
摘要: Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.
摘要翻译: 描述了方便大规模制备高异构纯度的D-赤型鞘氨醇和神经酰胺的合成方法。
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