公开(公告)号：US20160354468A1

公开(公告)日：2016-12-08

申请号：US15240221

申请日：2016-08-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/519 ,  A61N5/06 ,  A61K47/18 ,  A61K9/00 ,  A61K31/407 ,  A61K47/36

CPC classification number: A61K41/0071 ,  A61K9/0048 ,  A61K31/407 ,  A61K31/519 ,  A61K31/555 ,  A61K47/186 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0659

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

Abstract translation: 提供了一种眼用组合物，其包含用于光动力学治疗（PDT）的叶绿素或细菌叶绿素化合物，所述疾病，病症和病症与角膜或巩膜异常相关，例如角膜变薄和巩膜拉伸。

公开(公告)号：US20210330792A1

公开(公告)日：2021-10-28

申请号：US17370743

申请日：2021-07-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/407 ,  A61K31/555 ,  A61K9/00 ,  A61K31/519 ,  A61K47/36 ,  A61N5/06

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US20200297748A1

公开(公告)日：2020-09-24

申请号：US16847737

申请日：2020-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J.D. KARLISH ,  Adriana KATZ ,  Daniel M. TAL ,  Arie MARCOVICH

IPC: A61K31/7052 ,  C07H17/00 ,  C07J43/00 ,  A61P27/06 ,  A61P9/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

公开(公告)号：US20190231874A1

公开(公告)日：2019-08-01

申请号：US16196537

申请日：2018-11-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/407 ,  A61K47/36 ,  A61N5/06 ,  A61K31/555 ,  A61K47/18 ,  A61K31/519 ,  A61K9/00

CPC classification number: A61K41/0071 ,  A61K9/0048 ,  A61K31/407 ,  A61K31/519 ,  A61K31/555 ,  A61K47/186 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0659

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US20180207189A1

公开(公告)日：2018-07-26

申请号：US15745441

申请日：2016-07-19

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Steven J.D. KARLISH ,  Adriana KATZ ,  Daniel M. TAL ,  Arie MARCOVICH

IPC: A61K31/7052 ,  A61P27/06 ,  A61P9/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.