公开(公告)号：US20220202838A1

公开(公告)日：2022-06-30

申请号：US17700063

申请日：2022-03-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Memorial Sloan-Kettering Cancer Center

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Lilach AGEMY ,  Rachel HAMRI ,  Dina PREISE ,  Kwanghee KIM ,  Jonathan COLEMAN

IPC: A61K31/675 ,  A61K31/409 ,  A61K31/7068 ,  A61K31/7135 ,  A61K45/06 ,  A61P35/00

Abstract: An anti-myeloid-derived suppressor cells agent (“anti-MDSCs agent”) and a bacteriochlorophyll derivative (hereinafter”Bchl-D) for use in combination therapy for cancer. wherein the anti-MDSC agent and the Bchl-D are administered sequentially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).

公开(公告)号：US20160354468A1

公开(公告)日：2016-12-08

申请号：US15240221

申请日：2016-08-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/519 ,  A61N5/06 ,  A61K47/18 ,  A61K9/00 ,  A61K31/407 ,  A61K47/36

CPC classification number: A61K41/0071 ,  A61K9/0048 ,  A61K31/407 ,  A61K31/519 ,  A61K31/555 ,  A61K47/186 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0659

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

Abstract translation: 提供了一种眼用组合物，其包含用于光动力学治疗（PDT）的叶绿素或细菌叶绿素化合物，所述疾病，病症和病症与角膜或巩膜异常相关，例如角膜变薄和巩膜拉伸。

公开(公告)号：US20190231874A1

公开(公告)日：2019-08-01

申请号：US16196537

申请日：2018-11-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/407 ,  A61K47/36 ,  A61N5/06 ,  A61K31/555 ,  A61K47/18 ,  A61K31/519 ,  A61K9/00

CPC classification number: A61K41/0071 ,  A61K9/0048 ,  A61K31/407 ,  A61K31/519 ,  A61K31/555 ,  A61K47/186 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0659

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US20190125769A1

公开(公告)日：2019-05-02

申请号：US16092742

申请日：2017-04-10

Applicant: Yeda Research and Development Co. Ltd. ,  Memorial Sloan-Kettering Cancer Center

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  LiIach AGEMY ,  Rachel HAMRI ,  Dina PREISE ,  Kwanghee KIM ,  Jonathan COLEMAN

IPC: A61K31/675 ,  A61K31/409 ,  A61K31/7068 ,  A61K31/7135 ,  A61P35/00

Abstract: An anti-myeloid-derived suppressor cells agent (“anti-MDSCs agent”) and a bacteriochlorophyll derivative (hereinafter “Bchl-D) for use in combination therapy for cancer, wherein the anti-MDSC agent and the Bchl-D are administered sequentially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).

公开(公告)号：US20210330792A1

公开(公告)日：2021-10-28

申请号：US17370743

申请日：2021-07-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/407 ,  A61K31/555 ,  A61K9/00 ,  A61K31/519 ,  A61K47/36 ,  A61N5/06

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US20200094069A1

公开(公告)日：2020-03-26

申请号：US16397515

申请日：2019-04-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Alexander BRANDIS ,  Ohad MAZOR ,  Yoram SALOMON ,  Hugo SCHEER

IPC: A61N5/06 ,  C07F15/00 ,  C07F13/00 ,  C07F3/06 ,  C07F3/02 ,  C07F1/08 ,  A61K41/00 ,  A61F9/00 ,  C07F15/04 ,  A61K49/00 ,  A61K31/40

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.