公开(公告)号：US20150045291A1

公开(公告)日：2015-02-12

申请号：US14390372

申请日：2013-04-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Yechiel Shai ,  Avraham Ashkenazi

IPC: A61K47/48 ,  C07K14/005

CPC classification number: A61K47/543 ,  C07K14/005 ,  C12N2740/16122

Abstract: The invention provides conjugates comprising a short isolated peptide coupled to a sphingolipid, the peptide comprising a sequence derived from the HIV-1 gp41. The sphingolipid-peptide conjugates are suitable for treatment of infections caused by human and non-human retroviruses, especially HIV.

Abstract translation: 本发明提供了包含与鞘脂偶联的短分离肽的缀合物，所述肽包含衍生自HIV-1 gp41的序列。 鞘脂 - 肽缀合物适用于治疗人和非人类逆转录病毒，特别是艾滋病毒引起的感染。

公开(公告)号：US20150175666A1

公开(公告)日：2015-06-25

申请号：US14408950

申请日：2013-06-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yechiel Shai ,  Avraham Ashkenazi ,  Omri Faingold ,  Avraham Ben Nun ,  Nathali Kaushansky

IPC: C07K14/005 ,  A61K38/16 ,  C12N7/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K38/162 ,  C12N7/00 ,  C12N2740/16033 ,  C12N2740/16111 ,  C12N2740/16122

Abstract: The present invention provides peptides, derivatives and analogs comprising an amino acid sequence HTTWMEWD (SEQ ID NO: 1) derived from the ectodomain of HIV gp41 protein, pharmaceutical compositions comprising same, and uses thereof for therapy of T-cell mediated diseases and disorders.

Abstract translation: 本发明提供了包含衍生自HIV gp41蛋白的胞外域的氨基酸序列HTTWMEWD（SEQ ID NO：1）的肽，衍生物和类似物，包含其的药物组合物及其用于治疗T细胞介导的疾病和病症的用途。