-
公开(公告)号：US09925257B2
公开(公告)日：2018-03-27
申请号：US14604215
申请日：2015-01-23
IPC分类号： A61K39/02 , A61K39/00 , A61K39/08 , A61K39/21 , A61K39/04 , C07K14/33 , C07K14/35 , C07K14/005 , A61K45/06 , C07K14/315 , A61K39/12 , C12N9/24
CPC分类号： A61K39/21 , A61K39/04 , A61K39/08 , A61K39/12 , A61K45/06 , A61K2039/523 , A61K2039/541 , A61K2039/545 , A61K2039/58 , C07K14/005 , C07K14/315 , C07K14/33 , C07K14/35 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/55 , C12N9/2402 , C12N2740/15022 , C12N2740/15033 , C12N2740/16033 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.
-
公开(公告)号：US20170014479A1
公开(公告)日：2017-01-19
申请号：US15282022
申请日：2016-09-30
发明人： Xiao-jing WANG , Yosef REFAELI , Qinghong ZHANG
CPC分类号： A61K38/1709 , A61K31/7088 , A61K38/00 , A61K38/162 , A61K38/18 , A61K45/06 , C07K14/4703 , C07K2319/09 , C12N7/00 , C12N2740/16033
摘要： The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systematically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.
摘要翻译： 本发明提供了用于治疗炎症和/或组织损伤病症的方法和组合物。 特别地，描述了局部或系统地递送到炎症和/或组织损伤部位的Smad7组合物的使用。 其它具体实施方案涉及治疗或预防由辐射和/或化疗引起的副作用，包括但不限于粘膜炎。
-
3.发明申请公开(公告)号：US20160015759A1
公开(公告)日：2016-01-21
申请号：US14769025
申请日：2014-03-13
CPC分类号： A61K35/76 , A61K38/162 , A61K39/12 , A61K39/21 , C12N7/00 , C12N2740/16021 , C12N2740/16032 , C12N2740/16033 , C12N2740/16062 , A61K2300/00
摘要： The present disclosure provides an interfering, conditionally replicating human immunodeficiency virus (HIV) construct; infectious particles comprising the constructs; and compositions comprising the construct or the particle. The constructs, particles, and compositions are useful in methods of reducing HIV viral load in an individual, which methods are also provided.
摘要翻译： 本公开提供了干扰，有条件地复制的人类免疫缺陷病毒（HIV）构建体; 包含构建体的感染性颗粒; 和包含构建体或颗粒的组合物。 构建体，颗粒和组合物可用于减少个体中HIV病毒载量的方法，也提供了这些方法。
-
公开(公告)号：US20150239933A1
公开(公告)日：2015-08-27
申请号：US14630246
申请日：2015-02-24
CPC分类号： C07K7/08 , A61K38/00 , C07K14/00 , C07K14/005 , C07K14/162 , C12N2740/16033 , C12N2740/16122 , C12N2740/16134
摘要： Peptides and peptide analogs that competitively inhibit HIV protein gp120 and methods for making and using the same.
摘要翻译： 竞争性抑制HIV蛋白gp120的肽和肽类似物及其制备和使用方法。
-
5.发明授权Stabilized trimeric HIV-1 gp41 fusion polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif 有权包含N-末端七重复重复（NHR）和折叠（FD）三聚体基序的稳定的三聚体HIV-1 gp41融合多肽公开(公告)号：US09115186B2
公开(公告)日：2015-08-25
申请号：US12702209
申请日：2010-02-08
申请人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
发明人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
IPC分类号： C07K14/005 , A61K38/00
CPC分类号： A61K38/162 , A61K38/00 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2740/16022 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122
摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
摘要翻译： 本文公开了包含三种单体的三聚体多肽药物组合物，每种单体包含具有人类跨膜糖蛋白的N-末端七肽重复（NHR或HR1）或C-末端七重复重复（CHR或HR2）的氨基酸序列的多肽 免疫缺陷病毒（HIV）和三聚体基序。
-
公开(公告)号：US20150133384A1
公开(公告)日：2015-05-14
申请号：US14539578
申请日：2014-11-12
发明人： Joel F. Habener , Tatsuya Yano , Eva Tomas Falco
IPC分类号： C07K14/605 , C12N7/00 , C07K14/005
CPC分类号： C07K14/605 , A61K38/00 , C07K14/005 , C07K2319/10 , C12N7/00 , C12N2740/16033
摘要： C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP 1), and methods of use thereof, e.g., for the treatment of obesity and obesity-related disorders, e.g., diabetes and the metabolic syndrome.
摘要翻译： 胰高血糖素样肽-1（GLP 1）的C-末端片段及其使用方法，例如用于治疗肥胖症和肥胖相关疾病，例如糖尿病和代谢综合征。
-
7.发明申请TUBULIN-INTERACTING PROTEIN, CALTUBIN, PROMOTES AXONAL GROWTH 审中-公开TUBULIN相互作用的蛋白质，CALTUBIN，促进AXONAL GROWTH公开(公告)号：US20140329757A1
公开(公告)日：2014-11-06
申请号：US14351815
申请日：2012-10-12
发明人： Zhong-Ping Feng , Nasrin Najatbakhsh , Ronald E. Van Kasteren , August B. Smit , Hong-Shou Sun , Andrew Barszczyk
IPC分类号： C07K14/435 , C12N7/00 , C07K14/005
CPC分类号： C07K14/43504 , C07K14/005 , C07K2319/10 , C12N7/00 , C12N2740/16033
摘要： A novel isolated protein, referred to herein as “caltubin”, is provided. Caltubin promotes axonal regeneration, and prevents or at least reduces axonal retraction in neurons.
摘要翻译： 提供了一种新颖的分离的蛋白质，在本文中称为“钙调素”。 Caltubin促进轴突再生，并防止或至少减少神经元中的轴突回缩。
-
8.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20140005117A1
公开(公告)日：2014-01-02
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
-
9.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20130018003A1
公开(公告)日：2013-01-17
申请号：US13621597
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
-
10.发明申请TRIMERIC HIV FUSION INHIBITORS FOR TREATING OR PREVENTING HIV INFECTION 有权TRIMERIC艾滋病毒融合抑制剂治疗或预防艾滋病毒感染公开(公告)号：US20100204120A1
公开(公告)日：2010-08-12
申请号：US12702209
申请日：2010-02-08
申请人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
发明人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
CPC分类号： A61K38/162 , A61K38/00 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2740/16022 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122
摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
摘要翻译： 本文公开了包含三种单体的三聚体多肽药物组合物，每种单体包含具有人类跨膜糖蛋白的N-末端七肽重复（NHR或HR1）或C-末端七重复重复（CHR或HR2）的氨基酸序列的多肽 免疫缺陷病毒（HIV）和三聚体基序。
-
-
-
-
-
-
-
-
-
搜索结果
75 条记录 (耗时 0.038 秒)
