-
公开(公告)号：US09346854B2
公开(公告)日：2016-05-24
申请号：US14323408
申请日：2014-07-03
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yechiel Shai , Avner Fink , Shay Yaari , Tova Waks , Zelig Eshhar , Christopher J. Arnush
CPC classification number: C07K7/08 , A61K38/08 , C07K7/00 , C07K14/001
Abstract: Isolated peptides of 13-30 amino acids comprising 5-9 consecutive repeats of the amino acid pair Alanine-Leucine or Alanine-Valine are provided. The peptides further comprise a stretch of 1-3 Lysine residues present at least at one of the peptide's termini, wherein the only Lysine residue in the isolated peptide is present at the stretch of 1-3 Lysine residues. Pharmaceutical compositions comprising same, methods of treating inflammatory conditions and allergic reactions, as well as methods of neutralizing the activity of lypopolysaccharides are also provided.
Abstract translation: 提供了包含氨基酸对丙氨酸 - 亮氨酸或丙氨酸 - 缬氨酸的5-9个连续重复的13-30个氨基酸的分离的肽。 所述肽还包含存在于至少一个肽末端的1-3个赖氨酸残基，其中分离的肽中唯一的赖氨酸残基以1-3个赖氨酸残基的一段存在。 还提供了包含其的药物组合物，治疗炎性病症和过敏反应的方法，以及中和赖福多糖活性的方法。
-
Patent Agency Ranking
2.发明申请LIPOPEPTIDE CONJUGATES COMPRISING SPHINGOLIPID AND HIV GP41 DERIVED PEPTIDES 审中-公开含有SPHINGOLIPID和HIV GP41衍生肽的脂多糖公开(公告)号：US20150045291A1
公开(公告)日：2015-02-12
申请号：US14390372
申请日：2013-04-03
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： Yechiel Shai , Avraham Ashkenazi
IPC: A61K47/48 , C07K14/005
CPC classification number: A61K47/543 , C07K14/005 , C12N2740/16122
Abstract: The invention provides conjugates comprising a short isolated peptide coupled to a sphingolipid, the peptide comprising a sequence derived from the HIV-1 gp41. The sphingolipid-peptide conjugates are suitable for treatment of infections caused by human and non-human retroviruses, especially HIV.
Abstract translation: 本发明提供了包含与鞘脂偶联的短分离肽的缀合物，所述肽包含衍生自HIV-1 gp41的序列。 鞘脂 - 肽缀合物适用于治疗人和非人类逆转录病毒，特别是艾滋病毒引起的感染。
-
3.发明申请Toll-Like Receptor 4 (Tlr-4) Agonist Peptides For Modulating Tlr-4 Mediated Immune Response 审中-公开Toll样受体4（Tlr-4）用于调节Tlr-4介导的免疫应答的激动剂肽公开(公告)号：US20160184426A9
公开(公告)日：2016-06-30
申请号：US14249709
申请日：2014-04-10
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Yechiel Shai , Yosef Rosenfeld , Neta Sal-Man
CPC classification number: A61K39/39 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/705
Abstract: Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.
Abstract translation: 包括哺乳动物Toll样受体-4（TLR-4）片段的氨基酸序列，其类似物及其衍生物的肽和包括这些肽的药物组合物。 用于调节TLR-4介导的免疫应答的方法，特别是刺激TLR-4介导的免疫应答，从而治疗感染性疾病和癌症。
-
4.发明申请Toll-Like Receptor 4 (Tlr-4) Agonist Peptides For Modulating Tlr-4 Mediated Immune Response 审中-公开Toll样受体4（Tlr-4）用于调节Tlr-4介导的免疫应答的激动剂肽公开(公告)号：US20140220074A1
公开(公告)日：2014-08-07
申请号：US14249709
申请日：2014-04-10
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Yechiel Shai , Yosef Rosenfeld , Neta Sal-Man
CPC classification number: A61K39/39 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/705
Abstract: Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.
Abstract translation: 包括哺乳动物Toll样受体-4（TLR-4）片段的氨基酸序列，其类似物及其衍生物的肽和包括这些肽的药物组合物。 用于调节TLR-4介导的免疫应答的方法，特别是刺激TLR-4介导的免疫应答，从而治疗感染性疾病和癌症。
-
公开(公告)号：US20140336105A1
公开(公告)日：2014-11-13
申请号：US14323408
申请日：2014-07-03
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Yechiel Shai , Avner Fink , Shay Yaari , Tova Waks , Zelig Eshhar , Christopher J. Arnush
CPC classification number: C07K7/08 , A61K38/08 , C07K7/00 , C07K14/001
Abstract: Anti-inflammatory peptides and pharmaceutical compositions including lysine, alanine, leucine and/or valine for treating inflammatory conditions and uses thereof. Anti-inflammatory peptides for treating IgE-mediated allergies and inflammatory conditions caused by a microbial infection including but not limited to sepsis.
Abstract translation: 抗炎肽和药物组合物，包括用于治疗炎性病症的赖氨酸，丙氨酸，亮氨酸和/或缬氨酸及其用途。 用于治疗由微生物感染引起的IgE介导的过敏和炎性病症的抗炎肽，包括但不限于败血症。
-
6.发明申请PEPTIDES DERIVED FROM HIV GP41 FOR TREATING T-CELL MEDIATED PATHOLOGIES 审中-公开从HIV GP41衍生的肽用于治疗T细胞介导的病理学公开(公告)号：US20150175666A1
公开(公告)日：2015-06-25
申请号：US14408950
申请日：2013-06-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yechiel Shai , Avraham Ashkenazi , Omri Faingold , Avraham Ben Nun , Nathali Kaushansky
IPC: C07K14/005 , A61K38/16 , C12N7/00
CPC classification number: C07K14/005 , A61K38/00 , A61K38/162 , C12N7/00 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122
Abstract: The present invention provides peptides, derivatives and analogs comprising an amino acid sequence HTTWMEWD (SEQ ID NO: 1) derived from the ectodomain of HIV gp41 protein, pharmaceutical compositions comprising same, and uses thereof for therapy of T-cell mediated diseases and disorders.
Abstract translation: 本发明提供了包含衍生自HIV gp41蛋白的胞外域的氨基酸序列HTTWMEWD（SEQ ID NO：1）的肽，衍生物和类似物，包含其的药物组合物及其用于治疗T细胞介导的疾病和病症的用途。
-
-
-
-
-
Search Results
6
records
(took 0.04 seconds)
