公开(公告)号：US20240325456A1

公开(公告)日：2024-10-03

申请号：US18736635

申请日：2024-06-07

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Ran ORGAD ,  Irit MILMAN KRENTSIS ,  Xiaohua SU ,  Raj Kumar YADAV ,  Yangxi ZHENG

IPC: A61K35/42 ,  C12N5/071

CPC classification number: A61K35/42 ,  C12N5/0688 ,  C12N2501/11 ,  C12N2501/165 ,  C12N2501/727 ,  C12N2509/00

Abstract: Multipotent lung progenitor cells for lung regeneration are provided. Accordingly, there are provided methods of expanding in culture an isolated population of pulmonary cells, methods of qualifying suitability of an isolated population of pulmonary cells for administration to a subject in need thereof, and methods of generating an isolated population of pulmonary cells comprising selecting a cell population being double positive for expression of epithelial and endothelial cell markers. Also provided are isolated populations of pulmonary cells, pharmaceutical compositions comprising same and uses of same.

公开(公告)号：US20200289582A1

公开(公告)日：2020-09-17

申请号：US16885331

申请日：2020-05-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Irit MILMAN KRENTSIS

IPC: A61K35/42 ,  A61K45/06 ,  A61K31/015 ,  A61K35/12 ,  A61K35/28 ,  C12N5/071 ,  A61K9/00 ,  A61K31/255 ,  A61K31/675 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.

公开(公告)号：US20180169152A1

公开(公告)日：2018-06-21

申请号：US15737290

申请日：2016-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Irit MILMAN KRENTSIS

IPC: A61K35/42 ,  A61K31/675 ,  A61K31/255 ,  A61K9/00 ,  A61K45/06 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.