公开(公告)号：US20230256028A1

公开(公告)日：2023-08-17

申请号：US18137449

申请日：2023-04-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Carmit HILLEL-KARNIEL ,  Chava ROSEN ,  Esther BACHAR-LUSTIG ,  Elias SHEZEN

IPC: A61K35/42 ,  A61P11/00 ,  A61K9/00 ,  A61K35/28

CPC classification number: A61K35/42 ,  A61P11/00 ,  A61K9/0019 ,  A61K35/28

Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.

公开(公告)号：US20200289582A1

公开(公告)日：2020-09-17

申请号：US16885331

申请日：2020-05-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Irit MILMAN KRENTSIS

IPC: A61K35/42 ,  A61K45/06 ,  A61K31/015 ,  A61K35/12 ,  A61K35/28 ,  C12N5/071 ,  A61K9/00 ,  A61K31/255 ,  A61K31/675 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.

公开(公告)号：US20240325456A1

公开(公告)日：2024-10-03

申请号：US18736635

申请日：2024-06-07

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Ran ORGAD ,  Irit MILMAN KRENTSIS ,  Xiaohua SU ,  Raj Kumar YADAV ,  Yangxi ZHENG

IPC: A61K35/42 ,  C12N5/071

CPC classification number: A61K35/42 ,  C12N5/0688 ,  C12N2501/11 ,  C12N2501/165 ,  C12N2501/727 ,  C12N2509/00

Abstract: Multipotent lung progenitor cells for lung regeneration are provided. Accordingly, there are provided methods of expanding in culture an isolated population of pulmonary cells, methods of qualifying suitability of an isolated population of pulmonary cells for administration to a subject in need thereof, and methods of generating an isolated population of pulmonary cells comprising selecting a cell population being double positive for expression of epithelial and endothelial cell markers. Also provided are isolated populations of pulmonary cells, pharmaceutical compositions comprising same and uses of same.

公开(公告)号：US20150190546A1

公开(公告)日：2015-07-09

申请号：US14616837

申请日：2015-02-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yair REISNER ,  Benjamin DEKEL ,  Smadar EVENTOV-FRIEDMAN ,  Helena KATCHMAN ,  Elias SHEZEN ,  Anna ARONOVICH ,  Dalit TCHORSH-YUTSIS

IPC: A61L27/36 ,  A61L27/54

CPC classification number: A61L27/3604 ,  A61K35/22 ,  A61K35/407 ,  A61K35/54 ,  A61K39/39541 ,  A61K45/06 ,  A61L27/3641 ,  A61L27/54 ,  A61L2430/28 ,  A61K2300/00

Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.

Abstract translation: 公开了在有需要的受试者中治疗肾，肝或酶缺乏障碍的方法。 该方法通过移植到源自人或猪，肾或肝，肾或肝处于选定妊娠阶段的受试组织中来实现。

公开(公告)号：US20180169152A1

公开(公告)日：2018-06-21

申请号：US15737290

申请日：2016-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Irit MILMAN KRENTSIS

IPC: A61K35/42 ,  A61K31/675 ,  A61K31/255 ,  A61K9/00 ,  A61K45/06 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.

公开(公告)号：US20150174294A1

公开(公告)日：2015-06-25

申请号：US14641696

申请日：2015-03-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yair REISNER ,  Benjamin DEKEL ,  Smadar EVENTOV-FRIEDMAN ,  Helena KATCHMAN ,  Elias SHEZEN ,  Anna ARONOVICH ,  Dalit TCHORSH-YUTSIS

IPC: A61L27/36 ,  A61K45/06

CPC classification number: A61L27/3604 ,  A61K31/436 ,  A61K35/26 ,  A61K35/28 ,  A61K35/39 ,  A61K35/42 ,  A61K45/06 ,  A61L27/3641 ,  A61L2430/40 ,  A61K2300/00

Abstract: A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.

Abstract translation: 提供了向哺乳动物受试者提供胰腺，淋巴/造血或肺部器官和/或组织功能的方法。 该方法包括分别向受试者移植发育中的哺乳动物胰腺，淋巴/血管生成或肺部器官/组织移植物，从而分别产生功能性胰腺，淋巴/血管造影或肺部器官和/或组织，用于提供胰腺，淋巴/ 造血或肺部器官和/或组织功能。