公开(公告)号：US11633358B2

公开(公告)日：2023-04-25

申请号：US17190537

申请日：2021-03-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror ,  Weifeng Lin ,  Reut Mashiach

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US10940111B2

公开(公告)日：2021-03-09

申请号：US15319005

申请日：2015-06-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror ,  Weifeng Lin ,  Reut Mashiach

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.