公开(公告)号：US12116428B2

公开(公告)日：2024-10-15

申请号：US17872050

申请日：2022-07-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Weifeng Lin ,  Ronit Goldberg

IPC: C07F9/10 ,  A61K9/00 ,  A61K9/08 ,  A61K9/127 ,  A61P19/02 ,  C08F130/02 ,  A61K47/69

CPC classification number: C08F130/02 ,  A61K9/0051 ,  A61K9/08 ,  A61K9/1273 ,  A61P19/02 ,  C07F9/106 ,  A61K9/0019 ,  A61K47/6909 ,  C08F2438/01

Abstract: A polymeric compound is disclosed herein, having the general formula I:




wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US11684578B2

公开(公告)日：2023-06-27

申请号：US16485855

申请日：2018-02-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Weifeng Lin

IPC: A61K9/127 ,  A61P19/02 ,  A61K9/00

CPC classification number: A61K9/1273 ,  A61K9/0019 ,  A61P19/02

Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:



a) at least one bilayer-forming lipid;
b) a polymeric compound having the general formula I:










wherein m, n, L, X, Y, and Z are as defined herein; and
c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.

公开(公告)号：US10730976B2

公开(公告)日：2020-08-04

申请号：US16064498

申请日：2016-12-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Weifeng Lin ,  Ronit Goldberg

IPC: C07F9/10 ,  C08F130/02 ,  A61K9/127 ,  A61K9/08 ,  A61P19/02 ,  A61K9/00 ,  A61K47/69

Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US11633358B2

公开(公告)日：2023-04-25

申请号：US17190537

申请日：2021-03-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror ,  Weifeng Lin ,  Reut Mashiach

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US10940111B2

公开(公告)日：2021-03-09

申请号：US15319005

申请日：2015-06-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror ,  Weifeng Lin ,  Reut Mashiach

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.