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    Mucosal delivery tablet
    2.
    发明申请
    Mucosal delivery tablet 审中-公开
    粘膜递送片

    公开(公告)号：US20070048369A1

    公开(公告)日：2007-03-01

    申请号：US11212437

    申请日：2005-08-26

    申请人： Paul Foreman ,  Yeli Zhang ,  Reema Puri

    发明人： Paul Foreman ,  Yeli Zhang ,  Reema Puri

    IPC分类号： A61K9/20 ,  A61K31/24

    CPC分类号： A61K9/006 ,  A61K9/2027 ,  A61K9/2059 ,  A61K9/2095

    摘要： Mucoadhesive tablets have a convex surface, a diameter to cup depth ratio of 4-20 and a cup depth to edge thickness ratio of greater than 0.75 swiftly adheres and conforms to the contacting tissue. The tablets are used to administer actives such as, for example, benzocaine.

    摘要翻译： 粘膜糊剂具有凸表面，直径与杯深度比为4-20，杯深度与边缘厚度之比大于0.75，并迅速粘附，并符合接触组织。 片剂用于施用活性物质，例如苯佐卡因。

    Hydrogel entrapping therapeutic agent and stent with coating comprising this
    4.
    发明授权
    Hydrogel entrapping therapeutic agent and stent with coating comprising this 有权
    水凝胶包埋治疗剂和含有该涂层的涂层的支架

    公开(公告)号：US07138132B2

    公开(公告)日：2006-11-21

    申请号：US11037011

    申请日：2005-01-19

    申请人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    发明人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC分类号： C09D4/00 ,  A61L25/00 ,  A61L27/00 ,  A61L29/00

    CPC分类号： C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

    摘要翻译： 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。

    Tablet excipient
    7.
    发明授权
    Tablet excipient 有权
    片剂赋形剂

    公开(公告)号：US08871270B2

    公开(公告)日：2014-10-28

    申请号：US10888360

    申请日：2004-07-09

    申请人： Yeli Zhang ,  Chaodong Xiao ,  Wolfgang Bindzus ,  Vincent Green

    发明人： Yeli Zhang ,  Chaodong Xiao ,  Wolfgang Bindzus ,  Vincent Green

    IPC分类号： A61K9/14 ,  A61K47/36 ,  A61K9/20

    CPC分类号： A61K47/36 ,  A61K9/2059 ,  H01L27/3276 ,  H01L51/524 ,  H01L51/5246

    摘要： This invention relates to a composition comprising physically modified, partially pregelatinized starch, which is useful as a multi-functional excipient for solid dosage forms, a method of making such composition, and solid dosage forms prepared using the composition. Such composition is characterized by a predominance of particles having both birefringent and non-birefringent portions, a sedimentation volume of between 1.5 and 9 ml/g, and a cold water solubility of between 1 and 8%. This free-flowing starch may have an average particle size greater than 30 μm, and a moisture content of between 5 and 12% by weight. The 500 mg placebo tablet prepared from such composition at 13 kN using a manual tablet press equipped with a 1.11 cm ( 7/16″) standard concave punches has a crushing strength of at least 160 Newtons, and a disintegration time of no more than 10 minutes.

    摘要翻译： 本发明涉及包含物理修饰的部分预胶化淀粉的组合物，其可用作固体剂型的多功能赋形剂，制备该组合物的方法，以及使用该组合物制备的固体剂型。 这种组合物的特征在于具有双折射和非双折射部分的颗粒，沉淀体积为1.5至9ml / g，冷水溶解度为1至8％的颗粒为主。 这种自由流动的淀粉可以具有大于30μm的平均粒度和5至12重量％的水分含量。 使用配备有1.11cm（7/16“）标准凹形冲头的手动压片机以13kN由这种组合物制备的500mg安慰剂片具有至少160牛顿的破碎强度，并且崩解时间不超过10 分钟。

    Fine Particle Croscarmellose and Uses Thereof
    8.
    发明申请
    Fine Particle Croscarmellose and Uses Thereof 审中-公开
    细颗粒交联物及其用途

    公开(公告)号：US20110150993A1

    公开(公告)日：2011-06-23

    申请号：US12970153

    申请日：2010-12-16

    申请人： Yeli Zhang

    发明人： Yeli Zhang

    IPC分类号： A61K9/10 ,  A61K9/00 ,  A61K9/20 ,  A61K9/14

    CPC分类号： A61K9/2059 ,  A61K9/0056 ,  A61K47/38 ,  Y10T428/2982

    摘要： The disclosure is directed to fine particle croscarmellose and its use in various compositions such as solid dosage forms. More specifically, the present disclosure relates to fine particle croscarmellose having a median particle size of 5 μm to 36 μm and a volume mean diameter of 40 μm or less. The specific surface area is typically 0.3 m2/g or more. The fine particle croscarmellose is useful as a disintegrant.

    摘要翻译： 本公开涉及细颗粒交联羧甲基纤维素及其在各种组合物中的用途，例如固体剂型。 更具体地，本公开涉及中值粒径为5μm〜36μm，体积平均直径为40μm以下的细颗粒交联羧甲基纤维素。 比表面积通常为0.3m 2 / g以上。 细颗粒交联羧甲基纤维素可用作崩解剂。

    Tablet excipient
    9.
    发明申请
    Tablet excipient 有权
    片剂赋形剂

    公开(公告)号：US20060008521A1

    公开(公告)日：2006-01-12

    申请号：US10888360

    申请日：2004-07-09

    申请人： Yeli Zhang ,  Chaodong Xiao ,  Wolfgang Bindzus ,  Vincent Green

    发明人： Yeli Zhang ,  Chaodong Xiao ,  Wolfgang Bindzus ,  Vincent Green

    IPC分类号： A61K9/20

    CPC分类号： A61K47/36 ,  A61K9/2059 ,  H01L27/3276 ,  H01L51/524 ,  H01L51/5246

    摘要： This invention relates to a composition comprising physically modified, partially pregelatinized starch, which is useful as a multi-functional excipient for solid dosage forms, a method of making such composition, and solid dosage forms prepared using the composition. Such composition is characterized by a predominance of particles having both birefringent and non-birefringent portions, a sedimentation volume of between 1.5 and 9 ml/g, and a cold water solubility of between 1 and 8%. This free-flowing starch may have an average particle size greater than 30 μm, and a moisture content of between 5 and 12% by weight. The 500 mg placebo tablet prepared from such composition at 13 kN using a manual tablet press equipped with a 1.11 cm ( 7/16″) standard concave punches has a crushing strength of at least 160 Newtons, and a disintegration time of no more than 10 minutes.

    摘要翻译： 本发明涉及包含物理修饰的部分预胶化淀粉的组合物，其可用作固体剂型的多功能赋形剂，制备该组合物的方法，以及使用该组合物制备的固体剂型。 这种组合物的特征在于具有双折射和非双折射部分的颗粒，沉淀体积为1.5至9ml / g，冷水溶解度为1至8％的颗粒为主。 这种自由流动的淀粉可以具有大于30μm的平均粒度，并且水分含量在5至12重量％之间。 使用配备有1.11cm（7/16“）标准凹形冲头的手动压片机，以13kN由这种组合物制备的500mg安慰剂片具有至少160牛顿的破碎强度，并且崩解时间不超过 10分钟。

    Hydrogel entrapping therapeutic agent and stent with coating comprising this
    10.
    发明授权
    Hydrogel entrapping therapeutic agent and stent with coating comprising this 失效
    水凝胶包埋治疗剂和含有该涂层的涂层的支架

    公开(公告)号：US06716445B2

    公开(公告)日：2004-04-06

    申请号：US10143572

    申请日：2002-05-13

    申请人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    发明人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC分类号： A61K958

    CPC分类号： C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

    摘要翻译： 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。