公开(公告)号：US06635467B2

公开(公告)日：2003-10-21

申请号：US09938958

申请日：2001-08-24

申请人： Yen-Lin Chen ,  Ing-Er Hwang ,  Ming-Chih Lin ,  Ting-Kuo Huang ,  Chien-Cho Chen ,  Gwo-Fang Yuan

发明人： Yen-Lin Chen ,  Ing-Er Hwang ,  Ming-Chih Lin ,  Ting-Kuo Huang ,  Chien-Cho Chen ,  Gwo-Fang Yuan

IPC分类号： C12N100

CPC分类号： C12R1/645 ,  C12P1/02 ,  Y10S435/911

摘要： The invention relates to a mutant of Monascus purpureus, designated as Monascus purpureus M011, which is useful in the production of yellow pigments with a low amount of citrinin.

摘要翻译： 本发明涉及红曲红斑突变体，其被称为红曲霉属M011，其可用于生产少量柑橘素的黄色颜料。

公开(公告)号：US06485946B1

公开(公告)日：2002-11-26

申请号：US10161187

申请日：2002-06-03

申请人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

发明人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

IPC分类号： A01N4304

CPC分类号： C12P19/26 ,  C12N1/14 ,  Y10S435/911

摘要： The invention relates to a method of producing chitin or chitosan by culturing a Rhizopus azygosporus fungus or an Actinomucor taiwanensis fungus and isolating chitosan or chitin from the culture.

公开(公告)号：US06255085B1

公开(公告)日：2001-07-03

申请号：US09349807

申请日：1999-07-08

申请人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

发明人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

IPC分类号： C12P1926

CPC分类号： C12P19/26 ,  C12N1/14 ,  Y10S435/911 ,  Y10S435/939

摘要： The invention relates to a method of producing chitin or chitosan by culturing a Rhizopus azygosporus fungus or an Actinomucor taiwanensis fungus and isolating chitosan or chitin from the culture.

摘要翻译： 本发明涉及一种生产壳多糖或脱乙酰壳多糖的方法，该方法是通过培养一种天竺葵属真菌或一种放线菌（Actinomucor taiwanensis）真菌并从该培养物中分离脱乙酰壳多糖或壳多糖。

公开(公告)号：US06399338B1

公开(公告)日：2002-06-04

申请号：US09671959

申请日：2000-09-27

申请人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

发明人： Mei-Huei Chen ,  Hing-Yuen Chan ,  Chih-Lu Wu ,  Su-Hui Chuang ,  Ing-Er Hwang ,  Yen-Lin Chen ,  Gwo-Fang Yuan

IPC分类号： C12P1904

CPC分类号： C12P19/26 ,  C12N1/14 ,  Y10S435/911 ,  Y10S435/939

摘要： The invention relates to a method of producing chitin or chitosan by culturing a Rhizopus azygosporus fungus or an Actinomucor taiwanensis fungus and isolating chitosan or chitin from the culture.

摘要翻译： 本发明涉及一种生产壳多糖或脱乙酰壳多糖的方法，该方法是通过培养一种天竺葵属真菌或一种放线菌（Actinomucor taiwanensis）真菌并从该培养物中分离脱乙酰壳多糖或壳多糖。

公开(公告)号：US07067304B2

公开(公告)日：2006-06-27

申请号：US10629198

申请日：2003-07-29

申请人： Yen-Lin Chen ,  Ing-Er Hwang ,  Ming-Chin Lin ,  Chien-Cho Chen ,  Gwo-Fung Yuan

发明人： Yen-Lin Chen ,  Ing-Er Hwang ,  Ming-Chin Lin ,  Chien-Cho Chen ,  Gwo-Fung Yuan

IPC分类号： C12N1/14 ,  C12N1/16 ,  C12P7/52 ,  C12P1/02

CPC分类号： C12R1/645 ,  C12N1/14 ,  C12P13/04 ,  Y10S435/911

摘要： The invention relates to Monascus purpureus mutants, which are useful in the preparation of fermentation products having blood pressure lowering activity with a very low amount of citrinin.The invention also provides a process for preparing the fermentation products having blood pressure lowering activity using the Monascus purpureus mutants, and the use of the fermentation products in lowering blood pressure.

摘要翻译： 本发明涉及红曲霉突变体，其可用于制备具有降血压活性的发酵产物，其中极少量的柑橘素。 本发明还提供了使用红曲霉突变体制备具有降血压活性的发酵产物的方法，以及使用发酵产物降低血压。

公开(公告)号：US20120164120A1

公开(公告)日：2012-06-28

申请号：US13336234

申请日：2011-12-23

申请人： Ming-Jen Cheng ,  Ping-Hsun Yang ,  Ming-Der Wu ,  Shie-Jea Lin ,  Gwo-Fang Yuan ,  Yen-Lin Chen ,  Hsuen-Chun Liao ,  Kai-Ping Chen

发明人： Ming-Jen Cheng ,  Ping-Hsun Yang ,  Ming-Der Wu ,  Shie-Jea Lin ,  Gwo-Fang Yuan ,  Yen-Lin Chen ,  Hsuen-Chun Liao ,  Kai-Ping Chen

IPC分类号： A61K31/365 ,  A61K36/899 ,  A61K31/455 ,  A61K38/28 ,  A61K31/426 ,  C12P17/04 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P9/12 ,  A61P9/00 ,  C07D307/86 ,  A61P3/10

CPC分类号： C07D307/86 ,  A61K31/365 ,  A61K31/426 ,  A61K31/455 ,  A61K36/899 ,  A61K45/06 ,  A61K2236/19 ,  B01D15/18 ,  B01D15/424 ,  C12P17/04 ,  C12R1/645 ,  A61K2300/00

摘要： The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

摘要翻译： 本发明涉及如说明书中所述的式（I）的新型monascrourururur化合物或其药学上可接受的衍生物，其制备方法及其组合物。 用于促进脂肪细胞分化，增加PPARγ和/或C /EBPα的活性以降低血糖，用于预防和/或治疗与胰岛素抵抗相关的疾病或障碍的用途，以及用于预防和/或 还提供治疗代谢综合征或其并发症。

公开(公告)号：US09474774B2

公开(公告)日：2016-10-25

申请号：US12981915

申请日：2010-12-30

申请人： Ming-Der Wu ,  Ming-Jen Cheng ,  Shie-Jea Lin ,  Chi-Hua Chen ,  Yen-Lin Chen ,  Hui-Ping Chen ,  Kai-Ping Chen ,  Ping-Shin Yang ,  Shiow-Wen Chen ,  Gwo-Fang Yuan

发明人： Ming-Der Wu ,  Ming-Jen Cheng ,  Shie-Jea Lin ,  Chi-Hua Chen ,  Yen-Lin Chen ,  Hui-Ping Chen ,  Kai-Ping Chen ,  Ping-Shin Yang ,  Shiow-Wen Chen ,  Gwo-Fang Yuan

IPC分类号： A61K45/06 ,  A61K36/062 ,  A61K31/44 ,  C07D213/80 ,  C12P17/12 ,  C12R1/645

CPC分类号： A61K36/062 ,  A61K31/44 ,  A61K45/06 ,  C07D213/80 ,  C12P17/12 ,  C12R1/645 ,  A61K2300/00

摘要： The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

公开(公告)号：US08957057B2

公开(公告)日：2015-02-17

申请号：US12753918

申请日：2010-04-05

申请人： Ta-Wei D. Liu ,  Yen-Lin Chen ,  Ming-Der Wu ,  Ming-Jen Cheng ,  Hui-Ping Chen ,  Wen-Jung Wu ,  Kai-Ping Chen ,  Yu-Shan Lin ,  Gwo-Fang Yuan

发明人： Ta-Wei D. Liu ,  Yen-Lin Chen ,  Ming-Der Wu ,  Ming-Jen Cheng ,  Hui-Ping Chen ,  Wen-Jung Wu ,  Kai-Ping Chen ,  Yu-Shan Lin ,  Gwo-Fang Yuan

IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/365

CPC分类号： A61K31/365

摘要： The present invention concerns the uses of an azaphilone compound of formula (I):formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.

摘要翻译： 本发明涉及式（I）的阿扎伐隆化合物：式（I）：或其药学上可接受的衍生物在本说明书中所述的用于调节核激素受体的活性和用于预防和/或治疗 与核激素受体活性有关的疾病或病症。

公开(公告)号：US20110165186A1

公开(公告)日：2011-07-07

申请号：US12981915

申请日：2010-12-30

申请人： Ming-Der WU ,  Ming-Jen Cheng ,  Shie-Jea Lin ,  Chi-Hua Chen ,  Yen-Lin Chen ,  Hui-Ping Chen ,  Kai-Ping Chen ,  Ping-Shin Yang ,  Shiow-Wen Chen ,  Gwo-Fang Yuan

发明人： Ming-Der WU ,  Ming-Jen Cheng ,  Shie-Jea Lin ,  Chi-Hua Chen ,  Yen-Lin Chen ,  Hui-Ping Chen ,  Kai-Ping Chen ,  Ping-Shin Yang ,  Shiow-Wen Chen ,  Gwo-Fang Yuan

IPC分类号： A61K36/062 ,  C07D213/80 ,  A61K31/44 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  C12P17/12

CPC分类号： A61K36/062 ,  A61K31/44 ,  A61K45/06 ,  C07D213/80 ,  C12P17/12 ,  C12R1/645 ,  A61K2300/00

摘要： The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

摘要翻译： 本发明涉及式（I）的新型吡啶类生物碱化合物或其说明书所述的药学上可接受的衍生物，其制备方法及其组合物。 还提供了吡啶化合物用于增加PPARγ的活性，用于预防和/或治疗与胰岛素抵抗有关的疾病或病症以及预防和/或治疗代谢综合征或其并发症的用途。 本发明还提供红酵母发酵产物的提取物及其用于预防和/或治疗与胰岛素抵抗相关的疾病或病症如代谢综合征的用途。

公开(公告)号：US20100256227A1

公开(公告)日：2010-10-07

申请号：US12753918

申请日：2010-04-05

申请人： Ta-Wei D. LIU ,  Yen-Lin Chen ,  Ming-Der Wu ,  Ming-Jen Cheng ,  Hui-Ping Chen ,  Wen-Jung Wu ,  Kai-Ping Chen ,  Yu-Shan Lin ,  Gwo-Fang Yuan

发明人： Ta-Wei D. LIU ,  Yen-Lin Chen ,  Ming-Der Wu ,  Ming-Jen Cheng ,  Hui-Ping Chen ,  Wen-Jung Wu ,  Kai-Ping Chen ,  Yu-Shan Lin ,  Gwo-Fang Yuan

IPC分类号： A61K31/365 ,  A61P35/00 ,  A61P5/00 ,  A61P17/10

CPC分类号： A61K31/365

摘要： The present invention concerns the uses of an azaphilone compound of formula (I):formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.

摘要翻译： 本发明涉及式（I）的阿扎伐隆化合物：式（I）：或其药学上可接受的衍生物在本说明书中所述的用于调节核激素受体的活性和用于预防和/或治疗 与核激素受体活性有关的疾病或病症。