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1.发明申请NOVEL MONASCUSPURPURONES, PREPARATION PROCESS THEREOF, AND USES OF THE MONASCUSPURPURONES 审中-公开新世纪麻醉药品，其制备方法及其使用方法公开(公告)号：US20120164120A1
公开(公告)日：2012-06-28
申请号：US13336234
申请日：2011-12-23
Applicant: Ming-Jen Cheng , Ping-Hsun Yang , Ming-Der Wu , Shie-Jea Lin , Gwo-Fang Yuan , Yen-Lin Chen , Hsuen-Chun Liao , Kai-Ping Chen
Inventor： Ming-Jen Cheng , Ping-Hsun Yang , Ming-Der Wu , Shie-Jea Lin , Gwo-Fang Yuan , Yen-Lin Chen , Hsuen-Chun Liao , Kai-Ping Chen
IPC: A61K31/365 , A61K36/899 , A61K31/455 , A61K38/28 , A61K31/426 , C12P17/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/12 , A61P9/00 , C07D307/86 , A61P3/10
CPC classification number: C07D307/86 , A61K31/365 , A61K31/426 , A61K31/455 , A61K36/899 , A61K45/06 , A61K2236/19 , B01D15/18 , B01D15/424 , C12P17/04 , C12R1/645 , A61K2300/00
Abstract: The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.
Abstract translation: 本发明涉及如说明书中所述的式（I）的新型monascrourururur化合物或其药学上可接受的衍生物，其制备方法及其组合物。 用于促进脂肪细胞分化，增加PPARγ和/或C /EBPα的活性以降低血糖，用于预防和/或治疗与胰岛素抵抗相关的疾病或障碍的用途，以及用于预防和/或 还提供治疗代谢综合征或其并发症。
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公开(公告)号：US07087232B2
公开(公告)日：2006-08-08
申请号：US10697784
申请日：2003-10-30
Applicant: Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
Inventor： Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.
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3.发明授权Process for producing a culture of Antrodia camphorata and product obtained thereby 有权用于生产樟芝的培养物的方法及由此获得的产物公开(公告)号：US06767543B2
公开(公告)日：2004-07-27
申请号：US10113903
申请日：2002-03-29
Applicant: Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
Inventor： Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
IPC: A01N6500
Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.
Abstract translation: 本发明涉及建立适合于从樟芝的培养物中大量生产药理活性滤液的培养条件，特别是通过优化培养期间的搅拌速率和/或pH值。 本发明还涉及通过一系列分馏从樟芝的培养物获得药理学活性组合物的方法。 本发明进一步涉及上述组合物在制备药物组合物中的用途。
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4.发明授权Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids 有权吡啶生物碱，其制备方法以及吡啶生物碱的用途公开(公告)号：US09474774B2
公开(公告)日：2016-10-25
申请号：US12981915
申请日：2010-12-30
Applicant: Ming-Der Wu , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
Inventor： Ming-Der Wu , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
IPC: A61K45/06 , A61K36/062 , A61K31/44 , C07D213/80 , C12P17/12 , C12R1/645
CPC classification number: A61K36/062 , A61K31/44 , A61K45/06 , C07D213/80 , C12P17/12 , C12R1/645 , A61K2300/00
Abstract: The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.
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5.发明授权Process for producing a culture of Antrodia camphorata and product obtained thereby 有权用于生产樟芝的培养物的方法及由此获得的产物公开(公告)号：US07037711B2
公开(公告)日：2006-05-02
申请号：US10697782
申请日：2003-10-30
Applicant: Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
Inventor： Mei-Chiao Wu , Ren-Chang Huang , Shie-Jea Lin , Bor-Cheh Wang
Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.
Abstract translation: 本发明涉及建立适合于从樟芝的培养物中大量生产药理活性滤液的培养条件，特别是通过优化培养期间的搅拌速率和/或pH值。 本发明还涉及通过一系列分馏从樟芝的培养物获得药理学活性组合物的方法。 本发明进一步涉及上述组合物在制备药物组合物中的用途。
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Patent Agency Ranking
公开(公告)号：US06448053B1
公开(公告)日：2002-09-10
申请号：US09962908
申请日：2001-09-25
Applicant: Shie-Jea Lin , Chiou-Yen Wen , Wen-Haw Hsu , Guey-Yuh Liou , Wen-Shen Chu
Inventor： Shie-Jea Lin , Chiou-Yen Wen , Wen-Haw Hsu , Guey-Yuh Liou , Wen-Shen Chu
IPC: C12P704
CPC classification number: C12R1/645 , C12P7/18 , Y10S435/911 , Y10S435/917
Abstract: A method of producing erythritol. The method includes growing in a culture an isolated yeast strain that possesses certain unique characteristics and is capable of converting glucose to erythritol in a glucose-containing medium, and purifying erythritol from the culture.
Abstract translation: 赤藓糖醇的制造方法。 该方法包括在培养物中培养具有某些独特特征并能够将葡萄糖转化成含葡萄糖的培养基中的赤藓糖醇并从培养物中纯化赤藓糖醇的分离的酵母菌株。
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7.发明申请NOVEL PYRIDINE ALKALOIDS, PREPARATION PROCESS THEREOF, AND THE USES OF THE PYRIDINE ALKALOIDS 有权新型吡啶类碱性物质，其制备方法以及吡啶类碱性物质的用途公开(公告)号：US20110165186A1
公开(公告)日：2011-07-07
申请号：US12981915
申请日：2010-12-30
Applicant: Ming-Der WU , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
Inventor： Ming-Der WU , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
IPC: A61K36/062 , C07D213/80 , A61K31/44 , A61P3/04 , A61P3/10 , A61P9/00 , C12P17/12
CPC classification number: A61K36/062 , A61K31/44 , A61K45/06 , C07D213/80 , C12P17/12 , C12R1/645 , A61K2300/00
Abstract: The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.
Abstract translation: 本发明涉及式（I）的新型吡啶类生物碱化合物或其说明书所述的药学上可接受的衍生物，其制备方法及其组合物。 还提供了吡啶化合物用于增加PPARγ的活性，用于预防和/或治疗与胰岛素抵抗有关的疾病或病症以及预防和/或治疗代谢综合征或其并发症的用途。 本发明还提供红酵母发酵产物的提取物及其用于预防和/或治疗与胰岛素抵抗相关的疾病或病症如代谢综合征的用途。
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公开(公告)号：US07179628B2
公开(公告)日：2007-02-20
申请号：US10945705
申请日：2004-09-21
Applicant: Yi-Shin Lin , Mei-Li Chao , Chang-Hsiesh Liu , Min Tseng , Shie-Jea Lin , Wen-Shen Chu
Inventor： Yi-Shin Lin , Mei-Li Chao , Chang-Hsiesh Liu , Min Tseng , Shie-Jea Lin , Wen-Shen Chu
CPC classification number: C12N9/1044 , C12Y203/02013
Abstract: A DNA molecule encoding transglutaminase, a transglutaminase, an expression vector containing the DNA molecule, and a cell containing the expression vector.
Abstract translation: 编码转谷氨酰胺酶的DNA分子，转谷氨酰胺酶，含有DNA分子的表达载体和含有表达载体的细胞。
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9.发明授权Process for producing a culture of Antrodia camphorata and product obtained thereby 有权用于生产樟芝的培养物的方法及由此获得的产物公开(公告)号：US07157090B2
公开(公告)日：2007-01-02
申请号：US10697741
申请日：2003-10-30
Applicant: Mei-Chiao Wu , Shie-Jea Lin , Bor-Cheh Wang
Inventor： Mei-Chiao Wu , Shie-Jea Lin , Bor-Cheh Wang
Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.
Abstract translation: 本发明涉及建立适合于从樟芝的培养物中大量生产药理活性滤液的培养条件，特别是通过优化培养期间的搅拌速率和/或pH值。 本发明还涉及通过一系列分馏从樟芝的培养物获得药理学活性组合物的方法。 本发明进一步涉及上述组合物在制备药物组合物中的用途。
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公开(公告)号：US06916639B2
公开(公告)日：2005-07-12
申请号：US10200730
申请日：2002-07-22
Applicant: Shie-Jea Lin , Chiou-Yen Wen , Chang-Cheng Huang , Wen-Shen Chu
Inventor： Shie-Jea Lin , Chiou-Yen Wen , Chang-Cheng Huang , Wen-Shen Chu
CPC classification number: C12R1/645 , C12P7/18 , Y10S435/911
Abstract: An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
Abstract translation: 公开了一种将葡萄糖转化为赤藓糖醇的转化率至少为约45％的分离菌株，如从这种菌株生产赤藓糖醇的方法。
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