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    Polysaccharide compositions and uses thereof
    1.
    发明授权
    Polysaccharide compositions and uses thereof 失效
    多糖组合物及其用途

    公开(公告)号：US06485945B1

    公开(公告)日：2002-11-26

    申请号：US09444214

    申请日：1999-11-19

    申请人： Richard C. Potter ,  Philip A. Fisher ,  Kirk R. Hash, Sr. ,  John D. Neidt

    发明人： Richard C. Potter ,  Philip A. Fisher ,  Kirk R. Hash, Sr. ,  John D. Neidt

    IPC分类号： C12P1904

    CPC分类号： C08B37/0003 ,  C08B37/0024

    摘要： An entirely aqueous method for concentrating water soluble polysaccharides having molecular weights of at least about 50 kDa. The method comprises evaporating a water soluble polysaccharide-containing solution until surface film formation occurs, and harvesting the resulting film which is enriched in the polysaccharide. The polysaccharide may be of plant or animal origin, and includes polysaccharides such as guar gum, xanthan gum and pectin.

    摘要翻译： 用于浓缩分子量至少约为50kDa的水溶性多糖的完全水性方法。 该方法包括蒸发含水溶性多糖的溶液直到发生表面成膜，并且收获富含多糖的所得膜。 多糖可以是植物或动物来源的，并且包括多糖如瓜尔胶，黄原胶和果胶。

    Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    2.
    发明授权
    Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors 有权
    氨基烷基氨基葡糖苷磷酸酯化合物及其作为佐剂和免疫机制的用途

    公开(公告)号：US06764840B2

    公开(公告)日：2004-07-20

    申请号：US09905160

    申请日：2001-07-12

    申请人： David A. Johnson ,  C. Gregory Sowell

    发明人： David A. Johnson ,  C. Gregory Sowell

    IPC分类号： C12P1904

    CPC分类号： C07H15/04

    摘要： Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

    摘要翻译： 描述和要求保护作为佐剂和免疫作用剂的氨基葡糖苷磷酸（AGP）化合物。 该化合物具有与氨基烷基（糖苷配基）基团糖苷键连接的2-脱氧-2-氨基葡萄糖。 化合物在葡糖苷环上的4或6个碳上被磷酸化并且包含三个3-烷酰氧基烷酰基残基。 该化合物增加免疫动物的抗体产生，并刺激细胞因子产生并激活巨噬细胞。 还公开了使用化合物作为佐剂和免疫机制的方法。

    Microorganism isolated from chinese elm (Ulmus sp.) and process for preparing exopolysaccharides by employing the microorganism
    3.
    发明授权
    Microorganism isolated from chinese elm (Ulmus sp.) and process for preparing exopolysaccharides by employing the microorganism 失效
    从榆树（Ulmus sp。）分离的微生物和使用微生物制备胞外多糖的方法

    公开(公告)号：US06727081B2

    公开(公告)日：2004-04-27

    申请号：US09921013

    申请日：2001-07-27

    申请人： Young Lyeol Yang ,  Young Joo Kim

    发明人： Young Lyeol Yang ,  Young Joo Kim

    IPC分类号： C12P1904

    CPC分类号： C12R1/01 ,  A61K31/715 ,  C08B37/00 ,  C12P19/04 ,  Y10S435/822

    摘要： The present invention relates to a novel Enterobacter sp. strain SSYL deposited under accession number KCTC 0687BP isolated from the root bark of Chinese elm, which produces immunostimulating exopolysaccharides with anticancer activity, a process for preparing the exopolysaccharides by fermenting the said microorganism in a culture medium, exopolysaccharides prepared by the process and their uses thereof. The exopolysaccharides of the invention have a molecular weight of 100,000 to 1,000,000 and consist of 40-75% of total sugar, 5-15% of total acidic sugar and 10-25% of total protein. The exopolysaccharides exhibits a high immunoenhancing activity in immune cell proliferation, direct mitogenicity and mixed lymphocyte reaction, and further a high anticancer activity in vivo by virtue of immunostimulation. Moreover, the production of the exopolysaccharides by fermentation of a microorganism, makes it possible to provide the exopolysaccharides with a uniform quality and mass production without destruction of the plant species. The exopolysaccharides of the subject invention have practical uses as an active ingredient for anticancer agents, immunoenhancers and foodstuffs.

    摘要翻译： 本发明涉及一种新型肠杆菌属 以保藏号为KCTC 0687BP的中国榆皮根分离的菌株SSYL，其产生具有抗癌活性的免疫刺激性外多糖，通过在培养基中发酵所述微生物制备外多糖的方法，通过该方法制备的外多糖及其用途 。 本发明的外多糖的分子量为100,000至1,000,000，由总糖的40-75％，总酸性糖的5-15％和总蛋白的10-25％组成。 外多糖在免疫细胞增殖，直接有丝分裂原和混合淋巴细胞反应中表现出高的免疫增强活性，并通过免疫刺激进一步提高体内抗癌活性。 此外，通过微生物的发酵生产外多糖，使得可以提供均匀质量和大量生产的外多糖而不破坏植物物种。 本发明的外多糖作为抗癌剂，免疫增强剂和食品的活性成分具有实用性。

    Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    5.
    发明授权
    Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors 有权
    氨基烷基氨基葡糖苷磷酸酯化合物及其作为佐剂和免疫机制的用途

    公开(公告)号：US06303347B1

    公开(公告)日：2001-10-16

    申请号：US09439839

    申请日：1999-11-12

    申请人： David A. Johnson ,  C. Gregory Sowell

    发明人： David A. Johnson ,  C. Gregory Sowell

    IPC分类号： C12P1904

    CPC分类号： C07H13/06 ,  C07H15/04

    摘要： Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

    摘要翻译： 描述和要求保护作为佐剂和免疫作用剂的氨基葡糖苷磷酸（AGP）化合物。 该化合物具有与氨基烷基（糖苷配基）基团糖苷键连接的2-脱氧-2-氨基葡萄糖。 化合物在葡糖苷环上的4或6个碳上被磷酸化并且包含三个3-烷酰氧基烷酰基残基。 该化合物增加免疫动物的抗体产生，并刺激细胞因子产生并激活巨噬细胞。 还公开了使用化合物作为佐剂和免疫机制的方法。

    DNA sequences coding for enzymes capable of facilitating the synthesis of linear &agr;-1,4 glucans in plants, fungi and microorganisms
    6.
    发明授权
    DNA sequences coding for enzymes capable of facilitating the synthesis of linear &agr;-1,4 glucans in plants, fungi and microorganisms 失效
    编码能够促进在植物，真菌和微生物中合成线性α-1,4葡聚糖的酶的DNA序列

    公开(公告)号：US06818421B2

    公开(公告)日：2004-11-16

    申请号：US09843007

    申请日：2001-04-26

    申请人： Jens Kossmann ,  Volker Buttcher ,  Thomas Welsh

    发明人： Jens Kossmann ,  Volker Buttcher ,  Thomas Welsh

    IPC分类号： C12P1904

    CPC分类号： C12N9/1051 ,  C07H21/04 ,  C12N15/8246

    摘要： The invention relates to DNA sequences coding for proteins having the enzymatic activity of an amylosucrase which allows the synthesis of linear &agr;-1,4 glucans from the substrate sucrose by bacteria, fungi and plants or in cell-free systems. The invention furthermore describes plasmids and bacteria containing these DNA sequences as well as processes for the production of plants and microorganisms capable of intracellularly or extracellularly expressing a polypeptide having amylosucrase activity. The invention furthermore relates to the production of pure fructose using proteins exhibiting the enzymatic activity of amylosucrase.

    摘要翻译： 本发明涉及编码具有淀粉蔗糖酶的酶活性的蛋白质的DNA序列，其允许由细菌，真菌和植物或无细胞系统从底物蔗糖合成线性α-1,4葡聚糖。本发明还描述了质粒 和含有这些DNA序列的细菌，以及能够产生能够细胞内或细胞外表达具有淀粉蔗糖酶活性的多肽的植物和微生物的方法。本发明还涉及使用表现出淀粉蔗糖酶的酶活性的蛋白质生产纯果糖。