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公开(公告)号：US20110098285A1
公开(公告)日：2011-04-28
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/40 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/4709 , A61K31/501 , A61P25/28 , A61P11/06 , A61P25/00 , A61P25/16 , A61P3/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/30 , A61P3/10 , A61P3/04
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US08273767B2
公开(公告)日：2012-09-25
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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3.发明授权Process for preparing 2-methylpyrrolidine and specific enantiomers thereof 有权制备2-甲基吡咯烷的方法及其特定的对映异构体公开(公告)号：US07244852B2
公开(公告)日：2007-07-17
申请号：US10789106
申请日：2004-02-27
申请人： Yi-Yin Ku , Marlon D. Cowart , Padam N. Sharma
发明人： Yi-Yin Ku , Marlon D. Cowart , Padam N. Sharma
IPC分类号： C07D207/04
CPC分类号： C07D295/027 , C07D295/205
摘要： The invention relates to a process for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. Novel intermediates also are described.
摘要翻译： 本发明涉及2-甲基吡咯烷的制备方法，更具体地说，涉及2-甲基吡咯烷的特定对映异构体。 还描述了新的中间体。
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公开(公告)号：US07153889B2
公开(公告)日：2006-12-26
申请号：US10689735
申请日：2003-10-22
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07C13/465
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：US20090054420A1
公开(公告)日：2009-02-26
申请号：US12196124
申请日：2008-08-21
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/541 , C07D207/09 , C07D401/02 , C07D413/02 , C07D239/02 , C07D277/02 , C07D403/02 , C07D417/02 , C07D403/14 , A61P3/00 , A61P35/00 , A61P11/06 , A61P25/00 , A61P9/00 , A61K31/4725 , A61K31/4709 , A61K31/40 , A61K31/4439 , A61K31/422 , A61K31/506 , A61K31/5377 , A61K31/426 , A61K31/501
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20120108637A1
公开(公告)日：2012-05-03
申请号：US13335253
申请日：2011-12-22
申请人： Marlon D. COWART , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
发明人： Marlon D. COWART , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
IPC分类号： A61K31/455 , A61K31/428 , C07D417/14 , A61K31/4439 , C07D413/02 , A61K31/423 , A61P9/00 , A61P25/28 , A61P11/06 , A61P25/18 , A61P35/00 , A61P25/00 , A61P25/08 , A61P25/16 , C07D277/62
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这种化合物和组合物的方法。
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公开(公告)号：US20100298291A1
公开(公告)日：2010-11-25
申请号：US12847942
申请日：2010-07-30
申请人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
发明人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
IPC分类号： A61K31/397 , A61P25/28 , A61P11/06 , A61P9/10 , A61P25/30 , A61P25/00 , A61P3/10 , A61P25/06 , A61P25/16 , A61P25/18 , A61P3/00 , C07D417/02 , A61K31/428 , A61K31/4439 , C07D417/14 , A61K31/4709 , A61K31/506 , A61K31/55 , C07D413/02
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这些化合物和组合物的方法。
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8.发明授权公开(公告)号：US07098222B2
公开(公告)日：2006-08-29
申请号：US11123620
申请日：2005-05-06
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Michael P. Curtis
IPC分类号： A61K31/47 , A61K31/40 , C07D215/12 , C07D401/04 , C07D207/09
CPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X′, Y, Y′, Z, Z′, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 其中R 1或R 2的式（I）化合物是由L 2直接连接或连接的芳族或非芳族环， X，X'，Y，Y'，Z，Z'，R 1，R 3， R 3，R 3，R 3a，R 3b，R 4，R 3， 5，L，L 2和L 3 3如本文所定义，可用于治疗组胺3受体配体预防或改善的病症或病症 。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US08106088B2
公开(公告)日：2012-01-31
申请号：US12847942
申请日：2010-07-30
申请人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
发明人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
IPC分类号： A61K31/4025 , A61K31/404 , C07D403/06 , C07D209/04
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US07807697B2
公开(公告)日：2010-10-05
申请号：US12022041
申请日：2008-01-29
申请人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
发明人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4025 , C07D401/02 , C07D401/14 , C07D235/02 , C07D207/04
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这些化合物和组合物的方法。
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