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    MICRONEEDLE DEPOSITION METHOD
    3.
    发明申请
    MICRONEEDLE DEPOSITION METHOD 有权
    MICRONEEDLE沉积方法

    公开(公告)号：US20140257189A1

    公开(公告)日：2014-09-11

    申请号：US14352397

    申请日：2011-10-20

    申请人： Ying-shu Quan ,  Fumio Kamiyama

    发明人： Ying-shu Quan ,  Fumio Kamiyama

    IPC分类号： A61K9/00 ,  A61M37/00

    CPC分类号： A61K9/0021 ,  A61K9/08 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053

    摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.

    摘要翻译： 本发明提供了仅在微针部分中保持药物的微针阵列及其制造方法。 可以通过微针沉积法制造仅存在微针尖端的微针阵列2A，即a）使用水溶性聚合物作为基材制备微针阵列2; b）制备施加到微针阵列2的末端的药液1; 和c）微针阵列2的尖端与药物溶液1短时间接触。 当药物溶液1为水溶液时，生物降解性聚合物是水溶性的，除了药物之外，可生物降解的聚合物以高浓度溶解在溶液中，所施用的药物与微针一体化，使得只有 药物在插入过程中不会脱落。

    Apparatus for measuring diffusion of transdermal absorption preparation
    5.
    发明授权
    Apparatus for measuring diffusion of transdermal absorption preparation 有权
    用于测量经皮吸收制剂扩散的装置

    公开(公告)号：US08393199B2

    公开(公告)日：2013-03-12

    申请号：US12525305

    申请日：2007-01-31

    申请人： Fumio Kamiyama ,  Ying-shu Quan

    发明人： Fumio Kamiyama ,  Ying-shu Quan

    IPC分类号： G01N13/04

    CPC分类号： G01N13/00 ,  G01N2013/003

    摘要： This invention is to provide a diffusion testing device to facilitate determination of diffusivity of prolonged release of drugs from transdermal therapeutic preparation.The diffusion testing device is characterized by a receptor liquid reservoir; a diffusion testing cell having a receptor chamber functioning to be full of receptor liquid and within which a stirrer be placed, a receptor liquid supply unit, a thermostat bath to hold the diffusion testing cell, a stirring apparatus located beneath the thermostat bath to cause the rotation action of the stirrer set in the receptor chamber, a sampling unit permitting sampling and storage of receptor liquid dissolving permeated drugs. Said receptor liquid reservoir, said receptor chamber, said receptor liquid supply unit and said sampling unit are connected with each other via infusion tube. Said thermostat bath comprises aperturees or through-holes functioning to hold the diffusion testing cells, and metal block which has temperature regulation unit to be installed.

    摘要翻译： 本发明提供一种扩散测试装置，以便于确定药物从经皮治疗制剂中延长释放的扩散性。 扩散测试装置的特征在于受体液体储存器; 扩散测试电池，其具有充满受体液体并且其中放置搅拌器的受体室，受体液体供应单元，用于保持扩散测试电池的恒温槽，位于恒温槽下方的搅拌设备， 受体室中设置的搅拌器的旋转作用，允许取样和储存受溶液溶解渗透药物的取样单元。 所述受体液体储存器，所述受体室，所述受体液体供应单元和所述取样单元通过输注管相互连接。 所述恒温槽包括用于保持扩散测试电池的孔或通孔，以及具有要安装的温度调节单元的金属块。

    Microneedle deposition method
    7.
    发明授权
    Microneedle deposition method 有权

    公开(公告)号：US09993423B2

    公开(公告)日：2018-06-12

    申请号：US14352397

    申请日：2011-10-20

    申请人： Ying-shu Quan ,  Fumio Kamiyama

    发明人： Ying-shu Quan ,  Fumio Kamiyama

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/08

    CPC分类号： A61K9/0021 ,  A61K9/08 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053

    摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.

    TRANSDERMAL PHARMACEUTICAL PREPARATION
    8.
    发明申请
    TRANSDERMAL PHARMACEUTICAL PREPARATION 审中-公开
    超声波药物制备

    公开(公告)号：US20090148504A1

    公开(公告)日：2009-06-11

    申请号：US12359073

    申请日：2009-01-23

    申请人： Fumio Kamiyama ,  Ying-shu Quan

    发明人： Fumio Kamiyama ,  Ying-shu Quan

    IPC分类号： A61F13/02 ,  A61K31/4468

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/4468

    摘要： A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material, ingredients, and an active ingredient, wherein said adhesive base is a copolymer containing one or more (meth) alkyl acrylate monomers and one or more monomers copolymerizable with the (a) monomer selected from the group of unsaturated ethylenically unsaturated monomers, and said ingredients are diethylene glycol monocetyl ether, octanoic acid and/or oleic acid, lauric acid diethanolamide, polyvinylpyrollidone; and said active ingredient is fentanyl.

    摘要翻译： 一种胶带形式的经皮给药型药物制剂，其包含不能被活性成分渗透的柔性背衬和形成在所述柔性背衬上的粘合剂基层; 所述粘合剂基层基本上由粘合剂基材，成分和活性成分组成，其中所述粘合剂基是含有一种或多种丙烯酸（甲基）丙烯酸酯单体和一种或多种可与（a）单体共聚的单体的共聚物，所述单体选自 不饱和烯属不饱和单体组，所述成分是二甘醇单乙醚，辛酸和/或油酸，月桂酸二乙醇酰胺，聚乙烯吡咯烷酮; 所述活性成分是芬太尼。

    TRANSDERMALLY ABSORPTIVE PREPARATION
    9.
    发明申请
    TRANSDERMALLY ABSORPTIVE PREPARATION 审中-公开
    超吸收制剂

    公开(公告)号：US20100266670A1

    公开(公告)日：2010-10-21

    申请号：US12746594

    申请日：2008-12-09

    申请人： Akira Yamamoto ,  Toshiyasu Sakane ,  Hidemasa Katsumi ,  Fumio Kamiyama ,  Ying-shu Quan

    发明人： Akira Yamamoto ,  Toshiyasu Sakane ,  Hidemasa Katsumi ,  Fumio Kamiyama ,  Ying-shu Quan

    IPC分类号： A61K9/70 ,  A61K31/663 ,  A61P19/10 ,  A61P3/14

    CPC分类号： A61K31/663 ,  A61K9/7061 ,  A61K47/10 ,  A61K47/28 ,  A61K47/32

    摘要： This invention is to provide a transdermal administration type pharmaceutical preparation which has better transdermal absorptivity, safety and practical application for treatment of bone calcium metabolic diseases, such as high calcium in blood which resulted from osteoporosis, osteitis deformans and malignant tumors.A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material of acrylic copolymer, polyhydric alcohol and bisphosphonate or its derivatives, wherein the bisphosphonate or its derivatives are in their therapeutic dose, adhesive base material and polyhydric alcohol in a concentration ratio of 100:150 to 600 by weight; said acrylic copolymer are copolymerized by acrylic acid, 2-ethylhexyl acrylate and polar monomer (except for acrylic acid) in the concentration ratio of 50 to 88%:8 to 40%:1 to 40% by weight respectively. PEG modify and antioxidants are also applicable to reduce the skin stimulation.

    摘要翻译： 本发明提供一种透皮给药型药物制剂，其具有较好的经皮吸收性，安全性和实际应用，用于治疗由骨质疏松症，变形性骨畸形和恶性肿瘤引起的骨钙代谢疾病如血钙高。 一种胶带形式的经皮给药型药物制剂，其包含不能被活性成分渗透的柔性背衬和形成在所述柔性背衬上的粘合剂基层; 所述粘合剂基层主要由丙烯酸共聚物，多元醇和二膦酸盐或其衍生物的粘合剂基材组成，其中双膦酸盐或其衍生物的治疗剂量为粘合剂基材和多元醇，浓度比为100:50至 600重量份; 所述丙烯酸共聚物由丙烯酸，丙烯酸2-乙基己酯和极性单体（丙烯酸除外）以50〜88％的浓度比分别为8〜40％：1〜40重量％。 PEG修饰和抗氧化剂也适用于减少皮肤刺激。