专利检索 ap:("Yingzhi Bi" OR "Kenneth Gordon Carson" OR "Giovanni Cianchetta" OR "Michael Alan Green" OR "Godwin Kumi" OR "Alan Main" OR "Yulian Zhang" OR "Gregory Glenn Zipp") AND inv:"Michael Alan Green" 第 1 页

1.

发明授权
Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use 有权
标题翻译：咪唑并[1,2-b]哒嗪类化合物，包含它们的组合物及其使用方法

公开(公告)号：US08969565B2

公开(公告)日：2015-03-03

申请号：US13785271

申请日：2013-03-05

申请人： Yingzhi Bi , Kenneth Gordon Carson , Giovanni Cianchetta , Michael Alan Green , Godwin Kumi , Zhi Liang , Ying Jade Liu , Alan Main , Yulian Zhang , Gregory Glenn Zipp

发明人： Yingzhi Bi , Kenneth Gordon Carson , Giovanni Cianchetta , Michael Alan Green , Godwin Kumi , Zhi Liang , Ying Jade Liu , Alan Main , Yulian Zhang , Gregory Glenn Zipp

IPC分类号： C07D241/04 , C07D401/14 , C07D403/14 , C07D487/04 , A61K31/5025

CPC分类号： C07D487/04 , A61K31/5025 , C07D241/04 , C07D401/14 , C07D403/14 , C07D498/18 , C07D519/00

摘要： Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

摘要翻译： 公开了下式的咪唑并[1,2-b]哒嗪类化合物，其中R1，R2和R3如本文所定义。还公开了包含化合物的组合物及其用于治疗，治疗和/或预防由衔接子相关激酶1活性介导的疾病和病症的方法。

2.

发明授权
Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use 有权
标题翻译：吡唑并[1,5-a]嘧啶类化合物，包含它们的组合物及其用途

公开(公告)号：US08946415B2

公开(公告)日：2015-02-03

申请号：US13785355

申请日：2013-03-05

申请人： Yingzhi Bi , Kenneth Gordon Carson , Giovanni Cianchetta , Michael Alan Green , Godwin Kumi , Alan Main , Yulian Zhang , Gregory Glenn Zipp

发明人： Yingzhi Bi , Kenneth Gordon Carson , Giovanni Cianchetta , Michael Alan Green , Godwin Kumi , Alan Main , Yulian Zhang , Gregory Glenn Zipp

IPC分类号： C07D487/04 , A61K31/519

CPC分类号： C07D487/04 , A61K31/519 , C07B59/002 , C07B2200/05

摘要： Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.

摘要翻译： 公开了下式的吡唑并[1,5-a]嘧啶类化合物，其中R1，R2和R3在本文中定义。还公开了包含化合物的组合物及其用于治疗，治疗和/或预防由衔接子相关激酶1活性介导的疾病和病症的方法。

3.

发明申请
(S)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开
标题翻译：（S） - 苯基（甲基）甲基化合物，包含它们的组合物及其使用方法

公开(公告)号：US20090181992A1

公开(公告)日：2009-07-16

申请号：US12409640

申请日：2009-03-24

申请人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

发明人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

IPC分类号： A61K31/506 , C07D239/47 , A61P25/00

CPC分类号： C07D401/04

摘要： Multicyclic compounds and pharmaceutical compositions comprising them are described, along with methods of their use in the treatment of diseases such as age-associated memory impairment, Alzheimer's disease, Attention-Deficit/Hyperactivity Disorder (ADD/ADHD), autism, Down syndrome, Fragile X syndrome, Huntington's disease, Parkinson's disease, and schizophrenia. Compounds include those of formula I:

摘要翻译： 描述了包含它们的多环化合物和药物组合物，以及它们用于治疗诸如年龄相关记忆障碍，阿尔茨海默病，注意力缺陷/多动障碍（ADD / ADHD），自闭症，唐氏综合征，脆弱性 X综合征，亨廷顿病，帕金森病和精神分裂症。化合物包括式I的化合物：

4.

发明申请
(R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开
标题翻译：（R） - 苯基（杂环）甲醇基化合物，包含它们的组合物及其使用方法

公开(公告)号：US20080146596A1

公开(公告)日：2008-06-19

申请号：US11935051

申请日：2007-11-05

申请人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

发明人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

IPC分类号： A61K31/513 , C07D401/04 , C07K14/435 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/16 , A61K31/506

CPC分类号： C07D401/04

摘要： Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described. Compounds described include those of formula I:

摘要翻译： 描述了多环化合物，包含它们的药物组合物及其使用方法。描述的化合物包括式I的化合物：

5.

发明申请
(R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开
标题翻译：（R） - 苯基（杂环）甲醇基化合物，包含它们的组合物及其使用方法

公开(公告)号：US20090286820A1

公开(公告)日：2009-11-19

申请号：US12468176

申请日：2009-05-19

申请人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

发明人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

IPC分类号： A61K31/506 , C07D401/04 , A61P25/00

CPC分类号： C07D401/04

摘要： Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described. Compounds described include those of formula I:

摘要翻译： 描述了多环化合物，包含它们的药物组合物及其使用方法。描述的化合物包括式I的化合物：

6.

发明申请
(S)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开
标题翻译：（S） - 苯基（甲基）甲基化合物，包含它们的组合物及其使用方法

公开(公告)号：US20080146600A1

公开(公告)日：2008-06-19

申请号：US11935040

申请日：2007-11-05

申请人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

发明人： Joseph Barbosa , Yingzhi Bi , Cynthia Anne Fink , Michael Alan Green , Jian Cheng Wang

IPC分类号： A61K31/506 , C07D239/24 , A61P25/00

CPC分类号： C07D401/04

摘要： Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described. Compounds described include those of formula I:

摘要翻译： 描述了多环化合物，包含它们的药物组合物及其使用方法。描述的化合物包括式I的化合物：

7.

发明申请
DEACETYLASE INHIBITORS 审中-公开
标题翻译：脱乙酰酶抑制剂

公开(公告)号：US20080176849A1

公开(公告)日：2008-07-24

申请号：US12045885

申请日：2008-03-11

申请人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma

发明人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma

IPC分类号： A61K31/5377 , C07D209/04 , C07D209/82 , C07D217/00 , C07D471/04 , C07D413/12 , A61P35/00 , A61K31/404 , A61K31/403 , A61K31/47 , A61K31/437

摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

摘要翻译： 本发明提供了脱乙酰酶抑制剂的异羟肟酸酯化合物。该化合物适用于具有抗增殖性质的药物组合物。