专利检索 ap:("Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.") AND inv:"Yossi BUGANIM" 第 1 页

1.

发明公开
METHOD FOR REPROGRAMMING HUMAN CELLS 审中-公开

公开(公告)号：US20240131080A1

公开(公告)日：2024-04-25

申请号：US18537944

申请日：2023-12-13

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Yossi BUGANIM , Moriyah Naama SHACHAM

IPC分类号： A61K35/545 , A61K8/64 , A61Q19/00 , C12N5/073 , C12N15/86

CPC分类号： A61K35/545 , A61K8/64 , A61Q19/00 , C12N5/0605 , C12N15/86 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/00 , C12N2513/00 , C12N2533/92 , C12N2740/15043

摘要： A method of generating an induced trophoblast stem cell (iTSC) from a human cell is provided. Accordingly there is provided a method comprising expressing within a human cell GATA3 and OCT4 transcription factors, under conditions which allow generation of an iTSC from the cell. Also provided is a method of rejuvenating and/or de-differentiating a human cell. Also provided are nucleic acid constructs, protein preparation, isolated human cells, human iTSCs, rejuvenated cells and de-differentiated cells.