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    Distal cooling distribution system for a medical device
    1.
    发明授权
    Distal cooling distribution system for a medical device 有权
    用于医疗设备的远端冷却分配系统

    公开(公告)号：US09211393B2

    公开(公告)日：2015-12-15

    申请号：US11476416

    申请日：2006-06-28

    申请人： Yixin Hu ,  Vladimir Tzonev ,  Teresa Ann Mihalik ,  Benoit Thibault ,  Dan Wittenberger ,  Miriam Lane ,  Cristian Petre

    发明人： Yixin Hu ,  Vladimir Tzonev ,  Teresa Ann Mihalik ,  Benoit Thibault ,  Dan Wittenberger ,  Miriam Lane ,  Cristian Petre

    IPC分类号： A61M25/10 ,  A61M25/00 ,  A61M25/01 ,  A61B18/02 ,  A61B17/22 ,  A61B18/00

    CPC分类号： A61M25/1025 ,  A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/1061

    摘要： The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and the catheter. A housing may be disposed within the handle, with the housing defining a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the first and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.

    摘要翻译： 本发明可以包括具有手柄，耦合到手柄的导管和联接到导管的可扩张元件的医疗装置。 医疗装置还可以包括穿过手柄和导管的一段长度的第一和第二细长体。 壳体可以设置在手柄内，其中壳体限定能够容纳第一细长主体的一部分的第一开口，能够容纳第二细长主体的一部分的第二开口，以及与第一和第二 开口能够容纳第一和第二细长体的一部分。 分离元件可以设置在壳体内，其中分离元件限定能够接收第二细长主体的一部分的路径，并且由此第一细长主体的一部分围绕分离元件形成环。

    Distal cooling distribution system for a medical device
    2.
    发明申请
    Distal cooling distribution system for a medical device 有权
    用于医疗设备的远端冷却分配系统

    公开(公告)号：US20080097373A1

    公开(公告)日：2008-04-24

    申请号：US11476416

    申请日：2006-06-28

    申请人： Yixin Hu ,  Vladimir Tzonev ,  Teresa Ann Mihalik ,  Benoit Thibault ,  Dan Wittenberger ,  Miriam Lane ,  Cristian Petre

    发明人： Yixin Hu ,  Vladimir Tzonev ,  Teresa Ann Mihalik ,  Benoit Thibault ,  Dan Wittenberger ,  Miriam Lane ,  Cristian Petre

    IPC分类号： A61M25/10 ,  A61M29/02 ,  A61M25/00 ,  A61M31/00

    CPC分类号： A61M25/1025 ,  A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/1061

    摘要： The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and catheter. A housing may be disposed within the handle, with the housing defines a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.

    摘要翻译： 本发明可以包括具有手柄，耦合到手柄的导管和联接到导管的可扩张元件的医疗装置。 医疗装置还可以包括穿过手柄和导管的一段长度的第一和第二细长体。 壳体可以设置在手柄内，其中壳体限定能够容纳第一细长主体的一部分的第一开口，能够容纳第二细长主体的一部分的第二开口，以及与第一和第二 能够容纳第二细长体的一部分的开口。 分离元件可以设置在壳体内，其中分离元件限定能够接收第二细长主体的一部分的路径，并且由此第一细长主体的一部分围绕分离元件形成环。

    Endovascular cryotreatment catheter
    3.
    发明授权
    Endovascular cryotreatment catheter 有权
    血管内冷冻治疗导管

    公开(公告)号：US08298217B2

    公开(公告)日：2012-10-30

    申请号：US12410835

    申请日：2009-03-25

    申请人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Ann Mihalik

    发明人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Ann Mihalik

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.

    摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。 传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

    Dual injection tube cryocatheter and method for using same
    4.
    发明授权
    Dual injection tube cryocatheter and method for using same 有权

    公开(公告)号：US09931152B2

    公开(公告)日：2018-04-03

    申请号：US12844388

    申请日：2010-07-27

    申请人： Dan Wittenberger ,  Claudia Lueckge ,  Miriam Lane

    发明人： Dan Wittenberger ,  Claudia Lueckge ,  Miriam Lane

    IPC分类号： A61B18/02 ,  A61B18/00 ,  A61B90/00

    CPC分类号： A61B18/02 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00642 ,  A61B2018/0212 ,  A61B2090/064

    摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.

    Adjustable position injection tubing
    6.
    发明授权
    Adjustable position injection tubing 有权
    可调节位置注射管

    公开(公告)号：US06280439B1

    公开(公告)日：2001-08-28

    申请号：US09352021

    申请日：1999-07-12

    申请人： Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  Miriam Lane

    发明人： Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  Miriam Lane

    IPC分类号： A61B1802

    CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2018/00196 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： A cryogenic catheter includes an outer flexible member having a cryogenic fluid path defined by an injection tube disposed in the outer flexible member. The injection tube is slidably disposed within the outer flexible member. A guide member may be provided to support the injection tube within the outer flexible member. A wire is attached to the injection tube at one end and further attached to a spool to provide for take-up of the wire.

    摘要翻译： 低温导管包括具有由设置在外部柔性构件中的注射管限定的低温流体路径的外部柔性构件。 注射管可滑动地设置在外部柔性构件内。 可以设置引导构件以将注射管支撑在外部柔性构件内。 电线在一端连接到注射管，并进一步连接到线轴以提供线的卷绕。

    Endovascular cryotreatment catheter
    7.
    发明授权
    Endovascular cryotreatment catheter 有权
    血管内冷冻治疗导管

    公开(公告)号：US07527622B2

    公开(公告)日：2009-05-05

    申请号：US10887271

    申请日：2004-07-08

    申请人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

    发明人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

    IPC分类号： A61B18/18 ,  A61M29/00

    CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.

    摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。 传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

    ENDOVASCULAR CRYOTREATMENT CATHETER
    8.
    发明申请
    ENDOVASCULAR CRYOTREATMENT CATHETER 有权
    内膜切开导管

    公开(公告)号：US20090182319A1

    公开(公告)日：2009-07-16

    申请号：US12410835

    申请日：2009-03-25

    申请人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

    发明人： Miriam Lane ,  Marwan Abboud ,  Rachid Mahrouche ,  Teresa Mihalik

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.

    摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。 传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

    Tissue ablation system including guidewire with sensing element
    10.
    发明申请
    Tissue ablation system including guidewire with sensing element 审中-公开
    组织消融系统，包括带传感元件的导丝

    公开(公告)号：US20060135953A1

    公开(公告)日：2006-06-22

    申请号：US11021113

    申请日：2004-12-22

    申请人： Wlodzimierz Kania ,  Miriam Lane ,  Sean Carroll ,  Allan Skanes

    发明人： Wlodzimierz Kania ,  Miriam Lane ,  Sean Carroll ,  Allan Skanes

    IPC分类号： A61B18/02 ,  A61B5/04

    CPC分类号： A61B5/6851 ,  A61B5/6856 ,  A61B18/02 ,  A61B18/04 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00026 ,  A61B2017/00044 ,  A61B2017/00084 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/0212 ,  A61B2018/1407

    摘要： A tissue ablation system for ablating human tissue wherein sensing and ablation procedures are performed and controlled independently. A sensing wire is positioned distally to the ablation region and is adapted to pass thorough the ablation device such that it may move with or independently of the ablation device without obstructing the surface tissue interface of the ablation energy. The ablation device can ablate a substantial portion of a circumferential region of tissue, for example at or near the location where the pulmonary vein extends from the atrium. The tissue ablation system comprises an ablation device comprised of an elongated catheter with a proximal region and a distal region and an ablation element located proximate the distal region of the catheter. A sensing device having an elongated body with a proximal portion and a distal portion is adapted to be positioned within a vessel at or near a vessel ostium, wherein the sensing device is adapted to be slidably received within a lumen of the ablation device. The sensing device, a guide wire for example, may be shaped in various configurations to allow sensing device such as electrodes disposed thereon to contact the vessel wall near the ablation region. In this fashion, the sensing and ablation procedures are de-coupled such that the sensing device does not interfere or obstruct the ablation member's interface with the tissue.

    摘要翻译： 一种用于消融人体组织的组织消融系统，其中感测和消融程序被独立地执行和控制。 感测线位于远离切割区域并且适于穿过消融装置，使得其可以与消融装置移动或独立于消融装置移动，而不会阻碍消融能量的表面组织界面。 消融装置可以消除组织的周边区域的大部分，例如在肺静脉从心房延伸的位置处或附近。 组织消融系统包括消融装置，其包括具有近端区域和远侧区域的细长导管和位于导管远侧区域附近的消融元件。 具有具有近端部分和远端部分的细长主体的感测装置适于被定位在血管口中或附近的血管内，其中感测装置适于可滑动地容纳在消融装置的内腔内。 感测装置，例如引导线可以被成形为各种构造，以允许诸如设置在其上的电极的感测装置接触消融区域附近的血管壁。 以这种方式，感测和消融程序被去耦合，使得感测装置不干扰或阻碍消融构件与组织的界面。