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    Gastrointestinal mucosa-adherent matrixes pharmaceutical preparations and a coating composition
    3.
    发明授权
    Gastrointestinal mucosa-adherent matrixes pharmaceutical preparations and a coating composition 失效
    胃肠粘膜贴壁基质药物制剂和涂料组合物

    公开(公告)号：US06368635B1

    公开(公告)日：2002-04-09

    申请号：US08993314

    申请日：1997-12-18

    申请人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    发明人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    IPC分类号： A61K916

    CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/5026 ,  A61K9/5047 ,  Y10S514/952

    摘要： A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.

    摘要翻译： 一种在环境温度下为固体的固体基质组合物，其包含能够在与水接触时显现出粘度的粘性剂如丙烯酸聚合物，至少分散在含有 聚甘油脂肪酸酯或脂质和活性成分。 基质可以使得含有聚甘油脂肪酸酯或脂质和活性成分的基质颗粒已经涂覆有含有至少一种粘稠剂的涂料组合物。 这样的组合物可以粘附到消化道上并且长时间保持在那里，从而增加活性成分的生物利用度。 固体制剂，如细颗粒和颗粒，含有上述基质组成。

    Formulation comprising antibacterial substance and antiulcer substance
    4.
    发明授权
    Formulation comprising antibacterial substance and antiulcer substance 失效
    制剂含抗菌物质和抗溃疡物质

    公开(公告)号：US06319904B1

    公开(公告)日：2001-11-20

    申请号：US09348313

    申请日：1999-07-07

    申请人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    发明人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    IPC分类号： A61K3170

    CPC分类号： A61K45/06 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/43 ,  A61K31/44 ,  A61K2300/00 ,  A61K31/415

    摘要： The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present invention shows long retention time in the gastrointestinal tract because of adhesion to the gastrointestinal tract mucosa, synergetically enhances the pharmaceutical effects of an antibacterial substance, specially antibiotic against Helicobacter pylori (HP) and an antiulcer substance, with very low doses of active ingredients, particularly the anti-HP antibiotic with low prevalence of side effects. The present agent is useful as an antiulcer agent, showing potent anti-HP activity.

    摘要翻译： 本发明包括一种制剂，其包含抗菌物质和抗溃疡物质，其中至少任一种被配制成胃肠粘膜粘附固体制剂。 本发明的制剂由于与胃肠道粘膜的粘附而在胃肠道中保留时间长，协同增强抗菌物质的药物作用，特别是针对幽门螺杆菌（HP）和抗溃疡物质的抗生素，具有非常低的剂量 的活性成分，特别是副作用低的抗HP抗生素。 本发明的药剂可用作抗溃疡剂，显示出有效的抗HP活性。

    Controlled release composition
    6.
    发明授权
    Controlled release composition 有权
    控制释放组成

    公开(公告)号：US08980322B2

    公开(公告)日：2015-03-17

    申请号：US10549150

    申请日：2004-03-16

    申请人： Naoki Nagahara ,  Keiko Miyamoto ,  Yohko Akiyama

    发明人： Naoki Nagahara ,  Keiko Miyamoto ,  Yohko Akiyama

    IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/24

    CPC分类号： A61K9/209

    摘要： The present invention provides a controlled release composition showing release of an active ingredient (proton pump inhibitor) controlled in two or more steps at different release rates, which contains 1) a release-controlled part A capable of controlling release of the active ingredient to occur at a predetermined rate, 2) a release-controlled part B capable of controlling release of the active ingredient to occur at a predetermined rate lower than the release rate of the release-controlled part A, and where necessary, 3) a release-controlled part C capable of controlling release of the active ingredient to occur at a predetermined rate faster than the release rate of the release-controlled part B, wherein the release of the active ingredient from the release-controlled part B precedes the release of the active ingredient from the release-controlled part A (when release-controlled part C is contained, the release of the active ingredient from the release-controlled part C precedes the release of the active ingredient from the release-controlled part B).

    摘要翻译： 本发明提供一种控释组合物，其显示以不同释放速率控制两步或多步的活性成分（质子泵抑制剂）的释放，其包含1）能够控制活性成分释放的释放控制部分A 以预定的速率，2）释放控制部分B，其能够以比释放控制部分A的释放速率低的预定速率控制活性成分的释放，并且如果需要，3）释放控制 C部分能够以比释放控制部分B的释放速度更快的预定速率控制活性成分的释放，其中活性成分从释放控制部分B的释放先于活性成分的释放 从释放控制部分A（当含有释放控制部分C时，活性成分从释放控制部分C的释放先于th 从释放控制部分B释放活性成分。

    Controlled release composition
    7.
    发明申请
    Controlled release composition 有权

    公开(公告)号：US20060177509A1

    公开(公告)日：2006-08-10

    申请号：US10549150

    申请日：2004-03-16

    申请人： Naoki Nagahara ,  Keiko Miyamoto ,  Yohko Akiyama

    发明人： Naoki Nagahara ,  Keiko Miyamoto ,  Yohko Akiyama

    IPC分类号： A61K9/26

    CPC分类号： A61K9/209

    摘要： The present invention provides a controlled release composition showing release of an active ingredient (proton pump inhibitor) controlled in two or more steps at different release rates, which contains 1) a release-controlled part A capable of controlling release of the active ingredient to occur at a predetermined rate, 2) a release-controlled part B capable of controlling release of the active ingredient to occur at a predetermined rate lower than the release rate of the release-controlled part A, and where necessary, 3) a release-controlled part C capable of controlling release of the active ingredient to occur at a predetermined rate faster than the release rate of the release-controlled part B, wherein the release of the active ingredient from the release-controlled part B precedes the release of the active ingredient from the release-controlled part A (when release-controlled part C is contained, the release of the active ingredient from the release-controlled part C precedes the release of the active ingredient from the release-controlled part B).

    Controlled release preparation
    8.
    发明申请
    Controlled release preparation 有权
    控释制剂

    公开(公告)号：US20060013868A1

    公开(公告)日：2006-01-19

    申请号：US10531069

    申请日：2003-10-15

    申请人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    发明人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    IPC分类号： A61K9/54

    CPC分类号： A61K9/5026 ,  A61K9/2013 ,  A61K9/2846 ,  A61K9/5042 ,  A61K9/5073 ,  A61K9/5078 ,  A61K31/4439

    摘要： A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

    摘要翻译： 控制释放制剂，其中控制活性成分的释放，其通过在胃肠道中保持或缓慢迁移而释放活性成分延长的时间段，其通过诸如包封片剂，颗粒或细颗粒的方式提供，其中 控制活性成分的释放和凝胶形成聚合物。 所述片剂，颗粒或细颗粒具有形成在含有活性成分的核心颗粒上的释放控制涂层。

    Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition
    10.
    发明授权
    Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition 失效
    胃肠粘膜粘附颗粒，药物制剂和涂料组合物

    公开(公告)号：US5731006A

    公开(公告)日：1998-03-24

    申请号：US697166

    申请日：1996-08-20

    申请人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    发明人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K9/58 ,  A61K31/44 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/00 ,  A61P1/04 ,  A61P31/04

    CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/5026 ,  A61K9/5047 ,  Y10S514/952

    摘要： A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.

    摘要翻译： 一种在环境温度下为固体的固体基质组合物，其包含能够在与水接触时显现出粘度的粘性剂如丙烯酸聚合物，至少分散在含有 聚甘油脂肪酸酯或脂质和活性成分。 基质可以使得含有聚甘油脂肪酸酯或脂质和活性成分的基质颗粒已经涂覆有含有至少一种粘稠剂的涂料组合物。 这样的组合物可以粘附到消化道上并且长时间保持在那里，从而增加活性成分的生物利用度。 固体制剂，如细颗粒和颗粒，含有上述基质组成。