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24 条记录 (耗时 0.027 秒)

    Formulation comprising antibacterial substance and antiulcer substance
    2.
    发明授权
    Formulation comprising antibacterial substance and antiulcer substance 失效
    制剂含抗菌物质和抗溃疡物质

    公开(公告)号：US5948773A

    公开(公告)日：1999-09-07

    申请号：US863293

    申请日：1997-05-27

    申请人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    发明人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    IPC分类号： A61K9/16 ,  A61K9/32 ,  A61K9/50 ,  A61K9/58 ,  A61K31/43 ,  A61K31/44 ,  A61K45/06

    CPC分类号： A61K45/06 ,  A61K31/43 ,  A61K31/44 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/5078 ,  A61K9/5084

    摘要： The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present invention shows long retention time in the gastrointestinal tract because of adhesion to the gastrointestinal tract mucosa, synergetically enhances the pharmaceutical effects of an antibacterial substance, specially antibiotic against Helicobacter pylori (HP) and an antiulcer substance, with very low doses of active ingredients, particularly the anti-HP antibiotic with low prevalence of side effects. The present agent is useful as an anti ulcer agent, showing potent anti-HP activity.

    摘要翻译： 本发明包括一种制剂，其包含抗菌物质和抗溃疡物质，其中至少任一种被配制成胃肠粘膜粘附固体制剂。 本发明的制剂由于与胃肠道粘膜的粘附而在胃肠道中保留时间长，协同增强抗菌物质的药物作用，特别是针对幽门螺杆菌（HP）和抗溃疡物质的抗生素，具有非常低的剂量 的活性成分，特别是副作用低的抗HP抗生素。 本发明的药剂可用作抗溃疡剂，显示出有效的抗HP活性。

    Formulation comprising antibacterial substance and antiulcer substance
    3.
    发明授权
    Formulation comprising antibacterial substance and antiulcer substance 失效
    制剂含抗菌物质和抗溃疡物质

    公开(公告)号：US06319904B1

    公开(公告)日：2001-11-20

    申请号：US09348313

    申请日：1999-07-07

    申请人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    发明人： Yohko Akiyama ,  Masafumi Nakao ,  Naoki Nagahara ,  Susumu Iwasa

    IPC分类号： A61K3170

    CPC分类号： A61K45/06 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/43 ,  A61K31/44 ,  A61K2300/00 ,  A61K31/415

    摘要： The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present invention shows long retention time in the gastrointestinal tract because of adhesion to the gastrointestinal tract mucosa, synergetically enhances the pharmaceutical effects of an antibacterial substance, specially antibiotic against Helicobacter pylori (HP) and an antiulcer substance, with very low doses of active ingredients, particularly the anti-HP antibiotic with low prevalence of side effects. The present agent is useful as an antiulcer agent, showing potent anti-HP activity.

    摘要翻译： 本发明包括一种制剂，其包含抗菌物质和抗溃疡物质，其中至少任一种被配制成胃肠粘膜粘附固体制剂。 本发明的制剂由于与胃肠道粘膜的粘附而在胃肠道中保留时间长，协同增强抗菌物质的药物作用，特别是针对幽门螺杆菌（HP）和抗溃疡物质的抗生素，具有非常低的剂量 的活性成分，特别是副作用低的抗HP抗生素。 本发明的药剂可用作抗溃疡剂，显示出有效的抗HP活性。

    Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition
    4.
    发明授权
    Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition 失效
    胃肠粘膜粘附颗粒，药物制剂和涂料组合物

    公开(公告)号：US5731006A

    公开(公告)日：1998-03-24

    申请号：US697166

    申请日：1996-08-20

    申请人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    发明人： Yohko Akiyama ,  Naoki Nagahara ,  Shin-ichiro Hirai

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K9/58 ,  A61K31/44 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/00 ,  A61P1/04 ,  A61P31/04

    CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/5026 ,  A61K9/5047 ,  Y10S514/952

    摘要： A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.

    摘要翻译： 一种在环境温度下为固体的固体基质组合物，其包含能够在与水接触时显现出粘度的粘性剂如丙烯酸聚合物，至少分散在含有 聚甘油脂肪酸酯或脂质和活性成分。 基质可以使得含有聚甘油脂肪酸酯或脂质和活性成分的基质颗粒已经涂覆有含有至少一种粘稠剂的涂料组合物。 这样的组合物可以粘附到消化道上并且长时间保持在那里，从而增加活性成分的生物利用度。 固体制剂，如细颗粒和颗粒，含有上述基质组成。

    Controlled release preparation
    6.
    发明授权
    Controlled release preparation 有权
    控释制剂

    公开(公告)号：US08784885B2

    公开(公告)日：2014-07-22

    申请号：US12839054

    申请日：2010-07-19

    申请人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    发明人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    IPC分类号： A61K9/62

    CPC分类号： A61K9/5026 ,  A61K9/2013 ,  A61K9/2846 ,  A61K9/5042 ,  A61K9/5073 ,  A61K9/5078 ,  A61K31/4439

    摘要： A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

    摘要翻译： 控制释放制剂，其中控制活性成分的释放，其通过在胃肠道中保持或缓慢迁移而释放活性成分延长的时间段，其通过诸如包封片剂，颗粒或细颗粒的方式提供，其中 控制活性成分的释放和凝胶形成聚合物。 所述片剂，颗粒或细颗粒具有形成在含有活性成分的核心颗粒上的释放控制涂层。

    Controlled release preparation
    9.
    发明授权
    Controlled release preparation 有权
    控释制剂

    公开(公告)号：US07790755B2

    公开(公告)日：2010-09-07

    申请号：US10531069

    申请日：2003-10-15

    申请人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    发明人： Yohko Akiyama ,  Takashi Kurasawa ,  Hiroto Bando ,  Naoki Nagahara

    IPC分类号： A61K31/4439 ,  C07D401/02

    CPC分类号： A61K9/5026 ,  A61K9/2013 ,  A61K9/2846 ,  A61K9/5042 ,  A61K9/5073 ,  A61K9/5078 ,  A61K31/4439

    摘要： A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

    摘要翻译： 控制释放制剂，其中控制活性成分的释放，其通过在胃肠道中保持或缓慢迁移而释放活性成分延长的时间段，其通过诸如包封片剂，颗粒或细颗粒的方式提供，其中 控制活性成分的释放和凝胶形成聚合物。 所述片剂，颗粒或细颗粒具有形成在含有活性成分的核心颗粒上的释放控制涂层。