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47 条记录 (耗时 0.028 秒)

    1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
    4.
    发明授权
    1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders 有权
    1,5-二氢 - 吡唑并（3,4-D）嘧啶-4-酮衍生物及其用作治疗CNS紊乱的PDE9A混悬剂

    公开(公告)号：US08648085B2

    公开(公告)日：2014-02-11

    申请号：US12744750

    申请日：2008-11-27

    申请人： Christian Eickmeier ,  Cornelia Dorner-Ciossek ,  Dennis Fiegen ,  Thomas Fox ,  Klaus Fuchs ,  Riccardo Giovannini ,  Niklas Heine ,  Martin Hendrix ,  Holger Rosenbrock ,  Gerhard Schaenzle

    发明人： Christian Eickmeier ,  Cornelia Dorner-Ciossek ,  Dennis Fiegen ,  Thomas Fox ,  Klaus Fuchs ,  Riccardo Giovannini ,  Niklas Heine ,  Martin Hendrix ,  Holger Rosenbrock ,  Gerhard Schaenzle

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28 ,  A61P3/04 ,  A61P3/10 ,  A61P25/16

    CPC分类号： C07D487/04

    摘要： The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterized by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C2-C6-alky1 or Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C1-C6-alkylsulphonyl-amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.

    摘要翻译： 本发明涉及新的取代吡唑并嘧啶。 在化学上，化合物的特征在于通式（I）：其中R 1为苯基或吡啶基，其中任何一个被1至4个，优选1至3个取代基X取代; X独立地选自C 2 -C 6 - 烷基或C 1 -C 6 - 烷氧基，其中C 2 -C 6 - 烷基和C 1 -C 6 - 烷氧基至少被二卤代化为全卤代。 优选具有2至6个卤素取代基，并且卤素原子选自氟，氯和溴，优选氟; R 2是苯基或杂芳基，其中苯基被1至3个基团取代，杂芳基任选被1至3个基团取代，各自独立地选自C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，羟基羰基 氰基，三氟甲基，氨基，硝基，羟基，C 1 -C 6烷基氨基，卤素，C 6 -C 10 - 芳基羰基氨基，C 1 -C 6烷基羰基氨基，C 1 -C 6烷基氨基羰基。 C 1 -C 6 - 烷氧基羰基，C 6 -C 10 - 芳基氨基羰基，杂芳基氨基羰基。 杂芳基羰基氨基，C 1 -C 6烷基磺酰基 - 氨基，C 1 -C 6 - 烷基磺酰基和C 1 -C 6烷硫基; 新化合物应用于制造药物，特别是用于改善，感知，集中，学习和/或记忆有需要的患者的药物。

    Conditioning roller drive
    6.
    发明申请
    Conditioning roller drive 有权
    调节辊驱动

    公开(公告)号：US20060123759A1

    公开(公告)日：2006-06-15

    申请号：US11043433

    申请日：2005-01-27

    申请人： Thomas Fox ,  John Enns ,  Geoffrey Snider ,  James Dunn

    发明人： Thomas Fox ,  John Enns ,  Geoffrey Snider ,  James Dunn

    IPC分类号： G05G15/00

    CPC分类号： A01D82/02

    摘要： A forage conditioner for conditioning cut crop material from a forage harvester includes a fixed bottom fluted roller carried in end housings and a top fluted roller which is pivotally mounted on the housings by a linkage pivotal relative to the housing about an axis lying in a plane at right angles to the roller axes so that the top roller is liftable from crushing position against the bias of a spring extending along the top roller. Rotation of the bottom roller is transferred to the top roller through a gear train which includes two idler gears each mounted on a respective arm with the arms constrained to move symmetrically relative to the rollers by intermeshing teeth on the arms so as to control the angular timing of the rollers to ensure accurate intermeshing of the flutes.

    摘要翻译： 用于从饲料收割机调节切割作物材料的饲料调节器包括承载在端部壳体中的固定底部带槽辊和顶部带槽辊，其通过相对于壳体枢转地枢转地安装在壳体上的连接件围绕位于 与滚子轴线成直角，使得顶部辊可以克服沿着顶部辊子延伸的弹簧的偏压而从破碎位置提升。 下辊的旋转通过齿轮系传递到顶辊，该齿轮系包括两个惰轮，每个惰轮分别安装在相应的臂上，其中臂被限制为相对于辊对称地移动，通过相互啮合在臂上的齿，以便控制角定时 的滚子，以确保凹槽的精确啮合。

    System and method for predictive processor failure recovery
    7.
    发明申请
    System and method for predictive processor failure recovery 有权
    用于预测处理器故障恢复的系统和方法

    公开(公告)号：US20060010344A1

    公开(公告)日：2006-01-12

    申请号：US10888391

    申请日：2004-07-09

    申请人： Edward Zorek ,  Thomas Fox ,  Eric Kern ,  Michael Rollins ,  William Schwartz

    发明人： Edward Zorek ,  Thomas Fox ,  Eric Kern ,  Michael Rollins ,  William Schwartz

    IPC分类号： G06F11/00

    CPC分类号： G06F11/2043 ,  G06F11/2025 ,  G06F11/2028 ,  G06F11/203 ,  G06F11/2035

    摘要： A system, method, and computer program product for reporting and recovering from an internal processor error in a multiprocessor system supporting system management mode. In accordance with the method of the present invention one or more replacement agents are allocated such as during system startup within the multiprocessor system. Machine specific error-reporting registers are monitored for one or more active processor agents during system operation. In response to detecting a faulty agent via the monitoring, a system management interrupt (SMI) request is issued to one or both the faulty agent and a selected replacement agent. In response to receiving the SMI request, the operating state of the faulty agent is copied to the selected replacement agent in system management mode. Operating system processing is then resumed using the replacement agent.

    摘要翻译： 用于在支持系统管理模式的多处理器系统中从内部处理器错误报告和恢复的系统，方法和计算机程序产品。 根据本发明的方法，一个或多个替换代理被分配，例如在系统启动期间在多处理器系统内。 在系统操作期间，对一个或多个活动处理器代理监视机器特定的错误报告寄存器。 响应于通过监视检测故障代理，系统管理中断（SMI）请求被发送给故障代理和所选替换代理的一个或两个。 响应于接收到SMI请求，故障代理的操作状态将以系统管理模式复制到选定的替换代理。 然后使用更换代理恢复操作系统处理。