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    Optical resolution method of amlodipine
    5.
    发明授权
    Optical resolution method of amlodipine 失效
    氨氯地平的光学拆分方法

    公开(公告)号：US07772400B2

    公开(公告)日：2010-08-10

    申请号：US11792281

    申请日：2005-12-02

    申请人： Jae-Sun Kim ,  Jin Young Choi ,  Nam Ho Kim ,  Nam Kyu Lee

    发明人： Jae-Sun Kim ,  Jin Young Choi ,  Nam Ho Kim ,  Nam Kyu Lee

    IPC分类号： C07D213/803

    CPC分类号： C07D211/90

    摘要： The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.

    摘要翻译： 本发明涉及通过使用异丙醇溶剂和光学活性的O，O-二苯甲酰基酒石酸作为手性试剂来旋光拆分氨氯地平的方法。 更具体地说，本发明涉及一种方法，其包括（a）通过使（R，S） - 氨氯地平与光学活性的O，O-二苯甲酰基酒石酸盐反应获得（R） - 或（S） - 氨氯地平二苯甲酰酒石酸盐或其溶剂合物 异丙醇溶剂中的酸，和（b）用碱处理（R） - 或（S） - 氨氯地平盐，从而得到光学活性的氨氯地平。

    SHOCK ABSORBER
    6.
    发明申请
    SHOCK ABSORBER 审中-公开
    减震器

    公开(公告)号：US20090145708A1

    公开(公告)日：2009-06-11

    申请号：US12328688

    申请日：2008-12-04

    申请人： Nam Ho Kim

    发明人： Nam Ho Kim

    IPC分类号： F16F9/34

    CPC分类号： F16F9/5126

    摘要： Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod to divide the cylinder into a first chamber and a second chamber. The piston rod includes a hollow chamber formed within the piston rod, first and second orifices formed in upper and lower ends of the hollow chamber and connected to the first and second chambers, respectively, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, and a moving mechanism formed in the hollow chamber to move an operating fluid to upper and lower portions of the floating piston. The shock absorber can change a damping force according to a displacement of the piston rod, thereby improving driving comfort and stability of the vehicle.

    摘要翻译： 本文公开了一种用于根据道路状况阻尼传递到车辆的振动的减震器。 该减震器包括一气缸和一活塞阀，该气缸和一活塞阀设置在气缸内并与活塞杆连接，将气缸分成第一腔室和第二腔室。 活塞杆包括形成在活塞杆内的中空室，分别形成在中空室的上端和下端并分别连接到第一和第二腔的第一和第二孔，设置在中空室内的浮动活塞向上移动， 并且将中空室分成上下室，以及形成在中空室中的移动机构，以将工作流体移动到浮动活塞的上部和下部。 减震器可以根据活塞杆的位移改变阻尼力，从而提高车辆的行驶舒适性和稳定性。

    Process for Preparation of Chiral Amlodipine Gentisate
    7.
    发明申请
    Process for Preparation of Chiral Amlodipine Gentisate 审中-公开
    手性氨氯地平龙胆酸的制备方法

    公开(公告)号：US20080306277A1

    公开(公告)日：2008-12-11

    申请号：US12090264

    申请日：2006-10-17

    申请人： Jae-Sun Kim ,  Nam Ho Kim ,  Nam Kyu Lee

    发明人： Jae-Sun Kim ,  Nam Ho Kim ,  Nam Kyu Lee

    IPC分类号： C07D211/90

    CPC分类号： C07D211/90

    摘要： The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic (R,S)-amlodipine and optically pure O,O′-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare (R)- or (S)-amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid.

    摘要翻译： 本发明涉及一种制备光学纯氨氯地平龙胆酸盐的方法，更具体地说，涉及一种以高产率和高光学纯度制备光学纯氨氯地平龙胆酸盐的连续方法。 该方法可以通过在包含异丙醇的溶剂的存在下首先使外消旋（R，S） - 氨氯地平和光学纯的O，O-二苯甲酰基酒石酸反应来制备（R） - 或（S） - 氨氯地平二苯甲酰三酸盐非对映异构体或 溶剂合物，用碱处理制备的氨氯地平非对映体盐或其溶剂合物，然后最后加入龙胆酸。

    Apparatus and method for detecting a moving object in a sequence of color frame images
    8.
    发明授权
    Apparatus and method for detecting a moving object in a sequence of color frame images 失效
    用于检测彩色帧图像序列中的移动物体的装置和方法

    公开(公告)号：US06999604B1

    公开(公告)日：2006-02-14

    申请号：US09744250

    申请日：1998-08-07

    申请人： Hyoung Gon Kim ,  Sang Chul Ahn ,  Nam Ho Kim

    发明人： Hyoung Gon Kim ,  Sang Chul Ahn ,  Nam Ho Kim

    IPC分类号： G06K9/00

    CPC分类号： H04N19/543 ,  G06T7/254 ,  G06T9/001

    摘要： An apparatus and method for detecting a moving object in a sequence of color frame images is provided. The apparatus comprises a color normalizer for normalizing color components of the color frame image to produce a normalized frame image; a color transformer coupled to the color normalizer for color transforming the normalized frame image to a color transformed frame image; the color transformed frame image having intensity levels such that colors corresponding to said moving object are emphasized; a frame delay coupled to the color transformer for delaying the color transformed frame image by one frame; and a motion detector coupled to the color transformer and the frame delay for detecting the motion of the moving object and further intensifying the intensity levels of the color transformed frame image based on the detected motion.

    摘要翻译： 提供了一种用于检测彩色帧图像序列中的移动物体的装置和方法。 该装置包括用于对彩色图像的颜色分量进行归一化以产生标准化的帧图像的色彩归一化器; 耦合到所述颜色归一化器的颜色变换器，用于将所述归一化帧图像颜色变换为颜色变换的帧图像; 所述颜色变换的帧图像具有强调级别，使得对应于所述移动对象的颜色被强调; 帧延迟，耦合到色变换器，用于将彩色变换的帧图像延迟一帧; 以及运动检测器，其耦合到所述颜色变换器和所述帧延迟，用于检测所述运动对象的运动，并且基于检测到的运动进一步增强所述颜色变换的帧图像的强度水平。

    Toughening of thermosets
    10.
    发明授权
    Toughening of thermosets 失效
    热固性增韧

    公开(公告)号：US07550521B2

    公开(公告)日：2009-06-23

    申请号：US10519251

    申请日：2003-06-27

    申请人： Ho Sung Kim ,  Nam Ho Kim

    发明人： Ho Sung Kim ,  Nam Ho Kim

    IPC分类号： C08L63/00 ,  C08J9/00 ,  C08J7/00 ,  B32B27/38

    CPC分类号： C08J9/32 ,  B29C70/66 ,  C08J2203/22 ,  C08J2363/00 ,  C08K7/22

    摘要： A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.

    摘要翻译： 制造诸如环氧树脂的热固性材料的方法包括将如附图所示的随温度膨胀的可膨胀中空微球体添加到液相中的基础热固性组分，并对如此形成的混合物进行热处理，导致微球体膨胀 或固化后的热固性材料。 这导致由微球附近的压缩残余应力引起的增韧机理，这显着增加了环氧树脂的特定断裂能。