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公开(公告)号：US20150169991A1
公开(公告)日：2015-06-18
申请号：US13486167
申请日：2012-06-01
申请人： Yong Zhang , Charles J. Rosenberg , Jingbin Wang , Sean O'Malley
发明人： Yong Zhang , Charles J. Rosenberg , Jingbin Wang , Sean O'Malley
CPC分类号： G06K9/6267 , G06F17/30253 , G06F17/3053 , G06K9/52 , G06K9/6201 , G06K9/6202 , G06K9/6218 , G06K9/68 , G06K9/74
摘要： Methods, systems and apparatus for choosing image labels. In one aspect, a method includes receiving data specifying a first image, receiving text labels for the first image, receiving search results in response to a web search performed using at least some of the text labels as queries, ranking the text labels, at least in part, based on a number of resources referenced by the received search results, wherein at least some of the resources each include an image matching the first image, and selecting an image label for the image from the ranked text labels, the image label being selected based on the ranking.
摘要翻译： 用于选择图像标签的方法，系统和设备。 一方面，一种方法包括接收指定第一图像的数据，接收第一图像的文本标签，响应于使用至少一些文本标签作为查询执行的网页搜索接收搜索结果，至少对文本标签进行排序 部分地基于由所接收的搜索结果引用的资源的数量，其中，所述资源中的至少一些资源各自包括与所述第一图像匹配的图像，并且从所述排名的文本标签中选择所述图像的图像标签，所述图像标签为 根据排名选择。
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公开(公告)号：US09218546B2
公开(公告)日：2015-12-22
申请号：US13486167
申请日：2012-06-01
申请人： Yong Zhang , Charles J. Rosenberg , Jingbin Wang , Sean O'Malley
发明人： Yong Zhang , Charles J. Rosenberg , Jingbin Wang , Sean O'Malley
IPC分类号： G06K9/74
CPC分类号： G06K9/6267 , G06F17/30253 , G06F17/3053 , G06K9/52 , G06K9/6201 , G06K9/6202 , G06K9/6218 , G06K9/68 , G06K9/74
摘要： Methods, systems and apparatus for choosing image labels. In one aspect, a method includes receiving data specifying a first image, receiving text labels for the first image, receiving search results in response to a web search performed using at least some of the text labels as queries, ranking the text labels, at least in part, based on a number of resources referenced by the received search results, wherein at least some of the resources each include an image matching the first image, and selecting an image label for the image from the ranked text labels, the image label being selected based on the ranking.
摘要翻译： 用于选择图像标签的方法，系统和设备。 一方面，一种方法包括接收指定第一图像的数据，接收第一图像的文本标签，响应于使用至少一些文本标签作为查询执行的网页搜索接收搜索结果，至少对文本标签进行排序 部分地基于由所接收的搜索结果引用的资源的数量，其中，所述资源中的至少一些资源各自包括与所述第一图像匹配的图像，并且从所述排名的文本标签中选择所述图像的图像标签，所述图像标签为 根据排名选择。
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公开(公告)号：US09002831B1
公开(公告)日：2015-04-07
申请号：US13438934
申请日：2012-04-04
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/3025 , G06F17/30386
摘要： In general, in one aspect, a method includes receiving, by one or more processors, a query image, obtaining, by the one or more processors, search results responsive to the query image, each search result identifying a corresponding web page containing an image that is determined to be responsive to the query image, the search results being ordered in a first arrangement, obtaining, by the one or more processors, text labels associated with the query image, and generating, by the one or more processors a second arrangement of the search results by ordering the search results based on a presence in the respective corresponding web pages of one or more of the text labels associated with the query image. This and other implementations of this aspect can include corresponding systems, apparatus, and computer program products.
摘要翻译： 一般来说，一方面，一种方法包括：由一个或多个处理器接收查询图像，由一个或多个处理器获得响应于查询图像的搜索结果，每个搜索结果标识包含图像的相应网页 确定为响应于查询图像，搜索结果以第一布置排序，由一个或多个处理器获取与查询图像相关联的文本标签，并且由一个或多个处理器生成第二布置 通过基于与查询图像相关联的一个或多个文本标签的相应相应网页中的存在来排序搜索结果。 该方面的这个和其他实现可以包括相应的系统，装置和计算机程序产品。
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公开(公告)号：US09043316B1
公开(公告)日：2015-05-26
申请号：US13433137
申请日：2012-03-28
CPC分类号： G06K9/46 , G06F17/30247 , G06F17/30265
摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating image search results. One of the methods includes receiving first image search results responsive to a text query, each first image search result associated with a respective first score indicating a relevance of an image represented by the first image search result to the text query. Second image search results responsive to a query image are received, each second image search result associated with a respective second score indicating a measure of similarity between an image represented by the second image search result and the query image. A set of final image search results is selected including combining first scores and second scores of the selected first image search results. The final image search results are ordered by similarity to the query image.
摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于产生图像搜索结果。 方法之一包括响应于文本查询接收第一图像搜索结果，每个第一图像搜索结果与相应的第一分数相关联，所述第一分数指示由第一图像搜索结果表示的图像与文本查询的相关性。 接收响应于查询图像的第二图像搜索结果，每个第二图像搜索结果与相应的第二分数相关联，指示由第二图像搜索结果表示的图像与查询图像之间的相似度的度量。 选择一组最终图像搜索结果，包括组合所选择的第一图像搜索结果的第一分数和第二分数。 最终图像搜索结果与查询图像相似。
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公开(公告)号：US08983941B1
公开(公告)日：2015-03-17
申请号：US13621039
申请日：2012-09-15
IPC分类号： G06F17/30
CPC分类号： G06K9/46 , G06F17/30247 , G06F17/30265
摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating image search results. One of the methods includes receiving first image search results responsive to a text query, each first image search result associated with a respective first score indicating a relevance of an image represented by the first image search result to the text query. Second image search results responsive to a query image are received, each second image search result associated with a respective second score indicating a measure of similarity between an image represented by the second image search result and the query image. A set of final image search results is selected including combining first scores and second scores of the selected first image search results. The final image search results are ordered by similarity to the query image.
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6.发明授权Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease 有权类胡萝卜素类似物或衍生物用于抑制和改善肝脏疾病公开(公告)号：US07723327B2
公开(公告)日：2010-05-25
申请号：US10793660
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of treating liver disease in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译： 在受试者中治疗肝脏疾病的方法可包括向受试者施用有效量的药学上可接受的制剂。 药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。 受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。 类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。 共轭多烯可以包括包含至少一个取代基的环状环。 在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。 取代基可以用酯官能团偶联到环上。
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7.发明授权公开(公告)号：US07592449B2
公开(公告)日：2009-09-22
申请号：US11357897
申请日：2006-02-17
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： C07D233/12 , C07D265/30 , C07D473/00
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
摘要翻译： 用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种类胡萝卜素组合施用类胡萝卜素结构类似物，受试者中的活性氧，活性氮物质，自由基和/或非自由基 类似物或辅助抗氧化剂制剂。 给予类似物或模拟组合，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。 模拟或模拟组合可以施用于受试者以抑制和/或改善缺血再灌注损伤。 可以将受试者的类似物或类似物组合施用于肝脏疾病的抑制和/或改善。 类似物或类似物组合可以施用于受试者以抑制和/或改善癌症。 模拟或模拟组合可以施用于受试者以抑制和/或改善心律失常和/或心脏猝死。 类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。 在一个实施方案中，水溶性和/或水分散性虾青素类似物是特别有效的。 本发明还包括单独或组合包含结构类胡萝卜素类似物的药物组合物。
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8.发明授权Carotenoid analogs or derivatives for the inhibition and amelioration of disease 有权用于抑制和改善疾病的类胡萝卜素类似物或衍生物公开(公告)号：US07521584B2
公开(公告)日：2009-04-21
申请号：US10793670
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： C07C403/24
CPC分类号： C07D265/30 , C07C403/24 , C07D207/16 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a chemical compound including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译： 用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基 类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。 施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。 类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。 在一些实施方案中，本发明可以包括包含类胡萝卜素的类似物或衍生物的化合物。 类胡萝卜素类似物或衍生物可以是合成的。 类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。 共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。 在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。 取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。
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公开(公告)号：US20080051660A1
公开(公告)日：2008-02-28
申请号：US11833759
申请日：2007-08-03
IPC分类号： A61B8/06
CPC分类号： A61B8/543 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/469 , A61B8/481 , A61B8/488 , G01S7/52066 , G01S7/52071 , G01S15/8979 , G06K9/522
摘要： A set of intravascular ultrasound (IVUS) related systems, apparatuses and methods are disclosed. New catheter designs including contrast agent introduction subsystems and/or Doppler subsystems are disclosed. Methods for acquiring and analyzing Doppler data from intravascular ultrasound (IVUS) catheters are disclosed. RF-based detection of blood and/or contrast agents such as micro-bubbles are disclosed. Methods for frame-grating image data analysis permitting frame registration before, during and after a contrasting effect is imposed on a system being imaged are disclosed. Methods for difference imaging for contrast detection are disclosed. Methods for quantification and visualization of IVUS data are disclosed. And methods for IVUS imaging are disclosed.
摘要翻译： 公开了一组血管内超声（IVUS）相关系统，装置和方法。 公开了包括造影剂引入子系统和/或多普勒子系统的新导管设计。 公开了从血管内超声（IVUS）导管获取和分析多普勒数据的方法。 公开了血液和/或造影剂如微泡的基于RF的检测。 公开了对正在成像的系统施加对比效果之前，之中和之后帧对准的帧光栅图像数据分析的方法。 公开了用于对比度检测的差分成像的方法。 公开了IVUS数据的定量和可视化方法。 并公开了IVUS成像的方法。
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公开(公告)号：US20060229446A1
公开(公告)日：2006-10-12
申请号：US11357897
申请日：2006-02-17
申请人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
IPC分类号： C07H13/02 , C07D405/02
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
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