利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.051 秒)

    Carotenoid analogs or derivatives for controlling connexin 43 expression
    1.
    发明授权
    Carotenoid analogs or derivatives for controlling connexin 43 expression 有权
    用于控制连接蛋白43表达的类胡萝卜素类似物或衍生物

    公开(公告)号：US07763649B2

    公开(公告)日：2010-07-27

    申请号：US10793686

    申请日：2004-03-04

    申请人： Samuel Fournier Lockwood ,  Sean O'Malley ,  David G. Watumull ,  Laura M. Hix ,  Henry Jackson ,  Geoff Nadolski

    发明人： Samuel Fournier Lockwood ,  Sean O'Malley ,  David G. Watumull ,  Laura M. Hix ,  Henry Jackson ,  Geoff Nadolski

    IPC分类号： A61K31/34 ,  A61K31/35 ,  A61K31/335

    CPC分类号： C07D207/16 ,  C07C403/24 ,  C07D265/30 ,  C07D307/58 ,  C07F9/117 ,  C07H13/04

    摘要： A method of controlling (e.g., influencing or affecting) connexin 43 expression in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. In some embodiments, controlling connexin 43 expression in a subject may effectively treat cardiac arrhythmia and/or cancerous and pre-cancerous cells in a subject. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent.

    摘要翻译： 在受试者中控制（例如影响或影响）连接蛋白43表达的方法可包括向受试者施用有效量的药学上可接受的制剂。 在一些实施方案中，控制受试者中连接蛋白43的表达可以有效地治疗受试者的心律失常和/或癌前和癌前细胞。 药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。 受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。 类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。 共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。 在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。

    Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities
    2.
    发明申请
    Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities 审中-公开
    类胡萝卜素，类胡萝卜素类似物或类胡萝卜素衍生物用于治疗视力障碍

    公开(公告)号：US20060270589A1

    公开(公告)日：2006-11-30

    申请号：US11359984

    申请日：2006-02-22

    申请人： Samuel Lockwood ,  Geoff Nadolski

    发明人： Samuel Lockwood ,  Geoff Nadolski

    IPC分类号： A61K38/16 ,  A61K31/7034 ,  A61K31/66 ,  A61K31/185 ,  A61K31/12 ,  A61K31/015

    CPC分类号： A61K31/015 ,  A61K31/12 ,  A61K31/185 ,  A61K31/66 ,  A61K31/7034 ,  A61K2300/00

    摘要： A method and system used for treating visual disabilities using carotenoids, carotenoid analogs, and/or carotenoid derivatives. The analog, derivative, or intermediate may be administered such that a subject's risk of experiencing diseases associated with visual disabilities may be thereby reduced. Analogs or derivatives of carotenoids may include substituents including for example co-antioxidants (e.g., Vitamin C and Vitamin C analogs). The carotenoid analog or derivative may be synthetic. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

    摘要翻译： 用于使用类胡萝卜素，类胡萝卜素类似物和/或类胡萝卜素衍生物治疗视觉障碍的方法和系统。 可以给予类似物，衍生物或中间体，使得受试者可能因此降低与视力障碍相关的疾病的风险。 类胡萝卜素的类似物或衍生物可以包括取代基，例如共抗氧化剂（例如维生素C和维生素C类似物）。 类胡萝卜素类似物或衍生物可以是合成的。 类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。 共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。 在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。 取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

    Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
    6.
    发明申请
    Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation 审中-公开
    用于抑制和改善炎症的类胡萝卜素类似物或衍生物

    公开(公告)号：US20060058269A1

    公开(公告)日：2006-03-16

    申请号：US11214478

    申请日：2005-08-29

    申请人： Samuel Lockwood ,  Sean O'Malley ,  Henry Jackson ,  Geoff Nadolski

    发明人： Samuel Lockwood ,  Sean O'Malley ,  Henry Jackson ,  Geoff Nadolski

    IPC分类号： A61K31/66 ,  A61K31/015

    CPC分类号： A61K31/015 ,  A61K31/12 ,  A61K31/225 ,  A61K31/66 ,  A61K31/661 ,  A61K31/6615

    摘要： A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).

    摘要翻译： 一种抑制和/或改善人类受试者中疾病发生的方法，其中受试者单独或与另一种类胡萝卜素类似物或衍生物组合施用类胡萝卜素类似物或衍生物。 在一些实施方案中，类胡萝卜素类似物或衍生物的施用可以抑制和/或改善受试者中疾病的发生。 在一些实施方案中，类胡萝卜素的类似物或衍生物可以是水溶性的和/或水分散的。 可用本文体现的类胡萝卜素类似物或衍生物治疗的疟疾可能包括引发或触发炎性反应的疾病。 在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗哮喘。 在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响类花生酸的生物利用度。 在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗动脉粥样硬化。 在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响5-LO催化的类花生酸酯代谢物的生物利用度。 在一个实施方案中，可以通过向受试者施用类胡萝卜素的类似物或衍生物来控制或影响的5-LO-催化的类花生酸代谢物可以包括促炎效应分子（例如白三烯）。

    Carotenoid analogs or derivatives for the inhibition and amelioration of disease
    7.
    发明申请
    Carotenoid analogs or derivatives for the inhibition and amelioration of disease 有权
    用于抑制和改善疾病的类胡萝卜素类似物或衍生物

    公开(公告)号：US20050113372A1

    公开(公告)日：2005-05-26

    申请号：US10793670

    申请日：2004-03-04

    申请人： Samuel Lockwood ,  Sean O'Malley ,  David Watumull ,  Laura Hix ,  Henry Jackson ,  Geoff Nadolski

    发明人： Samuel Lockwood ,  Sean O'Malley ,  David Watumull ,  Laura Hix ,  Henry Jackson ,  Geoff Nadolski

    IPC分类号： A01N27/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/075 ,  A61K31/12 ,  A61K31/13 ,  A61K31/185 ,  A61K31/215 ,  A61K31/225 ,  A61K31/255 ,  A61K31/325 ,  A61K31/401 ,  A61K31/404 ,  A61K31/4172 ,  A61K31/535 ,  A61K31/537 ,  A61K31/66 ,  A61K31/665 ,  A61K31/70 ,  A61K31/704 ,  A61K31/715 ,  C07D207/16 ,  C07D233/60 ,  C07D265/30 ,  C07D307/58 ,  C07F9/02 ,  C07F9/117 ,  C07H13/04 ,  A01N31/14

    CPC分类号： C07D265/30 ,  C07C403/24 ,  C07D207/16 ,  C07D307/58 ,  C07F9/117 ,  C07H13/04

    摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a chemical compound including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

    摘要翻译： 用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基 类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。 施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。 类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。 在一些实施方案中，本发明可以包括包含类胡萝卜素的类似物或衍生物的化合物。 类胡萝卜素类似物或衍生物可以是合成的。 类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。 共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。 在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。 取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。