公开(公告)号：US06424986B1

公开(公告)日：2002-07-23

申请号：US09321664

申请日：1999-05-28

申请人： Yongming Li ,  Hongyi Chen ,  Xiaodong Wu

发明人： Yongming Li ,  Hongyi Chen ,  Xiaodong Wu

IPC分类号： G06F1714

CPC分类号： G06F17/148

摘要： A VLSI wavelet transform (WT) architecture suitable for use in a discrete wavelet transform (DWT) or a discrete wavelet packet transform (DWPT). The WT architecture has a multiplier; an accumulator; at least two address generators that has a first address generator and a second address generator; a control unit; a memory of result that stores computation results; and a memory of table, which pre-stores all possible weights, each of which weights is a product of some specified filter coefficients for performing a DWT/DWPT with parameters of decomposition level, length of data segment, and filter length. The first address generator and the control unit receive data input, the control unit exports control signals to multiplier, accumulator, second address generator, and memory of table. The memory of the table also receives outputs from the first address generator and the second address generator to select the desired weights of the filter coefficients, which are sent to the multiplier to obtain a product with the data input. The product is sent to the accumulator to add into a corresponding sum, and the memory of result receives the corresponding sum and an address output of the second address generator to address the received corresponding sum, in which when all of the data input in the DWT/DWPT are completely inputted, each the corresponding sum is an end result of the DWT/DWPT.

摘要翻译： 适用于离散小波变换（DWT）或离散小波包变换（DWPT）的VLSI小波变换（WT）架构。 WT架构有一个乘数; 蓄能器 至少两个具有第一地址发生器和第二地址发生器的地址发生器; 一个控制单元; 存储计算结果的结果记忆; 和表的存储器，其预存储所有可能的权重，其中每个权重是用于执行具有分解级别的参数，数据段的长度和过滤器长度的DWT / DWPT的一些指定的滤波器系数的乘积。 第一地址发生器和控制单元接收数据输入，控制单元将控制信号输出到乘法器，累加器，第二地址发生器和表的存储器。 表的存储器还接收来自第一地址发生器和第二地址发生器的输出，以选择滤波器系数的期望权重，这些权重被发送到乘法器以获得具有数据输入的乘积。 产品被发送到累加器以加入相应的和，并且结果的存储器接收第二地址发生器的相应的和和地址输出以寻址接收到的对应的和，其中当DWT中输入的所有数据 / DWPT完全输入，每个相应的和是DWT / DWPT的最终结果。

公开(公告)号：US6094631A

公开(公告)日：2000-07-25

申请号：US112949

申请日：1998-07-09

申请人： Yongming Li ,  Xiaodong Wu ,  Hongyi Chen

发明人： Yongming Li ,  Xiaodong Wu ,  Hongyi Chen

IPC分类号： G10L19/02 ,  H04N7/26 ,  G10L21/04

CPC分类号： G10L19/0212 ,  H04N19/61 ,  H04N19/63 ,  G10L25/27 ,  H04N19/115 ,  H04N19/146

摘要： A method of signal compression. An input signal is divided into a plurality of segments. Each of the segments is decomposed by wavelet packet transform to a plurality of levels, so that each of the segments is in a form of a group of coefficients in each of a plurality of domains corresponding to each of the levels. Each of the domains is divided into a plurality of sub-domains to calculate a degree of characteristic concentration corresponding thereto. One of the domains having a highest degree of characteristic concentration is select to perform bit allocation and quantization, so that the group of coefficients in the selected domain is represented as an information. The information is formatted into a frame for transmission, and then the frame is output.

摘要翻译： 一种信号压缩方法。 输入信号被分成多个段。 每个段通过小波包变换分解为多个级别，使得每个段在与每个级别对应的多个域中的每一个域中是一组系数的形式。 每个域被分成多个子域以计算与其对应的特征浓度的程度。 选择具有最高特征浓度度的区域之一来执行比特分配和量化，使得所选择的域中的系数组被表示为信息。 将信息格式化为一帧以进行传输，然后输出该帧。

公开(公告)号：US20190275086A1

公开(公告)日：2019-09-12

申请号：US16163542

申请日：2018-10-17

申请人： Xiaodong Wu ,  Sunil Krishnan

发明人： Xiaodong Wu ,  Sunil Krishnan

IPC分类号： A61K35/26 ,  A61N5/10 ,  C12N5/0783

摘要： The present invention as described herein is aimed at combining a radiation-induced immunogenic effect with a T-cell therapy technique to markedly improve the therapeutic effectiveness of adoptive T-cell therapy with minimized toxicity. The method of this invention comprises, identifying a target tumor, applying ablative radiation treatment to the tumor in-situ, waiting for the production of CTLs primed by antigen presenting cells (APC), then resecting the target tumor from the patient. The CTLs are harvested and isolated from the tumor and undergo ex-vivo expansion and subsequent treatment of immune checkpoint blockades. The expanded CTLs are then infused back into the patient for systemic treatment of microscopic disease. The primed CTLs that are induced by radiation in-situ, are used as the source of T-cell therapy or other types of cell therapy. The harvested CTLs will have high tumor specificity with a wide range of heterogeneous tumor associated antigens (TAA) presentation.

公开(公告)号：US20160230139A1

公开(公告)日：2016-08-11

申请号：US14948377

申请日：2015-11-22

申请人： Xiaodong Wu ,  Chandan Guha

发明人： Xiaodong Wu ,  Chandan Guha

IPC分类号： C12M1/00 ,  C12M1/12 ,  A61K39/00

CPC分类号： C12M47/06 ,  A61K39/0011 ,  A61K2039/5152 ,  C12M23/34 ,  C12M35/04 ,  C12M45/06 ,  C12M45/07 ,  C12M45/20 ,  C12M47/10 ,  C12M47/12

摘要： The invention disclosed herein aims to standardize and simplify the process of preparing Ex-Vivo autologous whole tumor cell vaccines. The present invention is a robust, stand-alone device and system for preparing autologous tumor cell vaccines in a completely self-contained sterile environment, and in a shortened time. This new device and system will process the extracted tumor with its associated stromal and endothelial cells into injectable tumor cell vaccines, administered automatically or semi-automatically. This invention incorporates a number of new biotechnologies to enhance therapeutic effects over other existing methods. This invention will allow a medical facility to prepare and administer autologous cancer cell vaccine therapy independently without having, or using, a GMP facility, while adhering to and maintaining GMP guidelines.

摘要翻译： 本文公开的发明旨在标准化和简化制备体外自体全肿瘤细胞疫苗的方法。 本发明是一种用于在完全独立的无菌环境中并在缩短的时间内制备自体肿瘤细胞疫苗的稳健的独立装置和系统。 这种新的装置和系统将将提取的肿瘤及其相关的基质和内皮细胞处理成可注射的肿瘤细胞疫苗，自动或半自动进行。 本发明结合了许多新的生物技术来增强对其他现有方法的治疗效果。 本发明将允许医疗机构在不附带或使用GMP设施的情况下独立地制备和施用自体癌细胞疫苗疗法，同时遵守和维护GMP指南。

公开(公告)号：US08618999B2

公开(公告)日：2013-12-31

申请号：US11940038

申请日：2007-11-14

申请人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

发明人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

IPC分类号： H01Q19/10 ,  H01Q1/38

CPC分类号： H01Q9/04 ,  H01Q19/10

摘要： A microwave motion sensor including a patch antenna having a plurality of microwave radiating elements for transmitting and receiving a microwave signal where each microwave radiating element is of the antenna in an array configuration. A reflector is disposed above the antenna for downward shaping the radiating signal, where the microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of said antenna and a sided lobe transmitted downward in amplitude below the microwave motion sensor.

摘要翻译： 一种微波运动传感器，包括具有多个微波辐射元件的贴片天线，用于发送和接收微波信号，其中每个微波辐射元件是阵列配置的天线。 反射器设置在天线上方，用于向下成形辐射信号，其中微波辐射元件与反射器一起提供辐射图，其中主光束在与所述天线的表面正交的方向上传输， 幅度低于微波运动传感器。

公开(公告)号：US20110055211A1

公开(公告)日：2011-03-03

申请号：US12674883

申请日：2008-08-22

申请人： Shishu Mei ,  Zhen Wang ,  Xiaodong Wu

发明人： Shishu Mei ,  Zhen Wang ,  Xiaodong Wu

IPC分类号： G06F17/30

CPC分类号： G06F21/6218 ,  H04N21/2541 ,  H04N21/25875 ,  H04N21/26613 ,  H04N21/6334

摘要： A system for sorting and classifying users of an image information management system is disclosed. The system for sorting and classifying users of an image information management system according to the present invention comprises some identical sub-systems, and every two sub-systems are interconnected. The sub-system comprises a user information encoding module, a user information decoding and authority identifying module, a user sorting module, a user classifying module, a command performing module, an authorized user collection database and a resource information database. The resource information database comprises real-time images, history images and control right commands of cradle heads and lens of cameras. The present invention resolves the problem of ordered accessing and utilizing of image information in a super-large-scale advanced real-time monitoring information management system, and realizes the object that local failures do not affect the normal work of the other parts by connecting every two sub-systems to each other and arranging the user identification entrance in each one of sub-systems.

摘要翻译： 公开了一种用于对图像信息管理系统的用户进行分类和分类的系统。 根据本发明的用于对图像信息管理系统的用户进行分类和分类的系统包括一些相同的子系统，并且每两个子系统互连。 子系统包括用户信息编码模块，用户信息解码和权限识别模块，用户分类模块，用户分类模块，命令执行模块，授权用户收集数据库和资源信息数据库。 资源信息数据库包括摇摄头和相机镜头的实时图像，历史图像和控制权命令。 本发明解决了超大规模高级实时监控信息管理系统中图像信息有序访问和利用的问题，实现了本地故障不影响其他部分的正常工作的对象，方法是连接每个 两个子系统彼此并且在每个子系统中布置用户识别入口。

公开(公告)号：US20100320402A1

公开(公告)日：2010-12-23

申请号：US12819212

申请日：2010-06-20

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US07616148B2

公开(公告)日：2009-11-10

申请号：US11286206

申请日：2005-11-23

申请人： Xiaodong Wu ,  Harold L. Holvick ,  Leslie K. Green ,  James N. Helland

发明人： Xiaodong Wu ,  Harold L. Holvick ,  Leslie K. Green ,  James N. Helland

IPC分类号： G01S13/62

CPC分类号： G08B13/2494 ,  G08B29/183

摘要： A dual mode motion sensor for detecting both motion of a moving target and a range of the moving target. The dual mode motion sensor normally operates in a pulse transmission mode. If motion is detected, the sensor automatically switches to a frequency modulated continuous wave transmission mode. This will allow the sensor to determine the range of the moving target. The sensor includes a microcontroller that compares the determined range of the moving target with a predetermined maximum detection range. If the determined range is outside or exceeds the predetermined maximum detection range the sensor will ignore the motion. If the determined range is within the predetermined maximum detection range, an alarm will be generated.

摘要翻译： 一种用于检测移动目标的运动和移动目标的范围的双模运动传感器。 双模运动传感器通常在脉冲传输模式下工作。 如果检测到运动，则传感器自动切换到调频连续波传输模式。 这将允许传感器确定移动目标的范围。 该传感器包括将所确定的移动目标的范围与预定的最大检测范围进行比较的微控制器。 如果确定的范围超出或超过预定的最大检测范围，传感器将忽略该运动。 如果所确定的范围在预定的最大检测范围内，则将产生报警。

公开(公告)号：US20090121958A1

公开(公告)日：2009-05-14

申请号：US11940038

申请日：2007-11-14

申请人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

发明人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

IPC分类号： H01Q19/10 ,  H01Q9/04

CPC分类号： H01Q9/04 ,  H01Q19/10

摘要： A microwave motion sensor including a patch antenna having a plurality of microwave radiating elements for transmitting and receiving a microwave signal where each microwave radiating element is of the antenna in an array configuration. A reflector is disposed above the antenna for downward shaping the radiating signal, where the microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of said antenna and a sided lobe transmitted downward in amplitude below the microwave motion sensor.

摘要翻译： 一种微波运动传感器，包括具有多个微波辐射元件的贴片天线，用于发送和接收微波信号，其中每个微波辐射元件是阵列配置的天线。 反射器设置在天线上方，用于向下成形辐射信号，其中微波辐射元件与反射器一起提供辐射图，其中主光束在与所述天线的表面正交的方向上传输， 幅度低于微波运动传感器。

公开(公告)号：US20080317308A1

公开(公告)日：2008-12-25

申请号：US12001066

申请日：2007-12-07

申请人： Xiaodong Wu ,  Mona Garvin ,  Michael David Abramoff ,  Milan Sonka

发明人： Xiaodong Wu ,  Mona Garvin ,  Michael David Abramoff ,  Milan Sonka

IPC分类号： G06K9/00

CPC分类号： G06K9/4638 ,  G06K9/469 ,  G06K9/6224 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/149 ,  G06T7/162 ,  G06T2207/10076 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/20161 ,  G06T2207/30041 ,  G06T2207/30048 ,  G06T2207/30101

摘要： A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods are provided that are capable of simultaneously detecting multiple interacting surfaces in which the optimality is controlled by the cost functions designed for individual surfaces and by several geometric constraints defining the surface smoothness and interrelations. The graph search applications use objective functions that incorporate non-uniform cost terms such as “on-surface” costs as well as “in-region” costs.

摘要翻译： 提供了一种用于在体数据集中表示对象边界的全局最优表面的有效分割的系统和方法。 提供了一种光学表面检测系统和方法，其能够同时检测多个相互作用的表面，其中最优性由为各个表面设计的成本函数以及限定表面平滑度和相互关系的若干几何约束来控制。 图形搜索应用程序使用包含不均匀成本术语的目标函数，例如“在地面”成本以及“区域内”成本。