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1.发明授权Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved 有权针对骨膜素的抗体，以及包含其用于预防或治疗涉及骨膜素的疾病的药物组合物公开(公告)号：US08372957B2
公开(公告)日：2013-02-12
申请号：US13198618
申请日：2011-08-04
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。
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2.发明申请Antibody Against Periostin, and a Pharmaceutical Composition comprising it for Preventing or Treating a Disease in which Periostin is Involved 有权抗骨质素的抗体和包含其用于预防或治疗其中涉及骨膜素的疾病的药物组合物公开(公告)号：US20090074788A1
公开(公告)日：2009-03-19
申请号：US12147331
申请日：2008-06-26
IPC分类号： A61K39/395 , C07K16/00 , G01N33/68 , A61P25/00 , A61P1/18 , A61P31/12 , A61P35/00 , A61P11/00 , A61P9/00 , C12N5/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。
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3.发明授权Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved 有权针对骨膜素的抗体，以及包含其用于预防或治疗涉及骨膜素的疾病的药物组合物公开(公告)号：US08017119B2
公开(公告)日：2011-09-13
申请号：US12147331
申请日：2008-06-26
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。
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公开(公告)号：US20090087916A1
公开(公告)日：2009-04-02
申请号：US10594927
申请日：2005-03-30
IPC分类号： G01N33/68 , A61N7/00 , C07H19/24 , C07D311/30 , C07H15/20 , C07C49/248 , C07D279/20 , C07K1/107
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2500/04 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides a method of identifying a drug candidate capable of removing peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which includes measuring, in the presence of a test compound, the concentration of a soluble peptide, a soluble oligopeptide, a soluble polypeptide or a soluble protein in an equilibrium state in a solvent. Moreover, the present invention provides a dissolution promoter to remove peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which contains the compound obtained by the identification method as an active ingredient.
摘要翻译： 本发明提供鉴定能够从原纤维或骨料中除去肽，寡肽，多肽或蛋白质的候选药物的方法，该方法包括在受试化合物存在下测定可溶性肽，可溶性寡肽， 可溶性多肽或在溶剂中处于平衡状态的可溶性蛋白质。 此外，本发明提供了从原纤维或聚集体中除去肽，寡肽，多肽或蛋白质的溶解促进剂，其含有通过鉴定方法获得的化合物作为活性成分。
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公开(公告)号：US20070293447A1
公开(公告)日：2007-12-20
申请号：US10570052
申请日：2004-08-27
申请人： Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
发明人： Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
CPC分类号： A61K9/0024 , A61K31/7088 , A61K48/0075
摘要： The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 μg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.
摘要翻译： 本发明提供用于治疗皮肤病症，特别是顽固性皮肤病症的非常有用的临床方法。 具体地说，所述方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸，例如DNA，寡核苷酸，RNA，siRNA和反义，在与皮肤病症如伤口，皮肤溃疡相关的病变周围 或牛皮癣，使用无针注射器，其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。
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6.发明申请Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus 审中-公开超声波药物输送和医学诊断成像仪的方法和装置公开(公告)号：US20090069678A1
公开(公告)日：2009-03-12
申请号：US12087407
申请日：2007-01-05
CPC分类号： A61M37/0092 , A61B5/413 , A61B5/4839 , A61B6/508 , A61B8/00
摘要： According to the present invention, there are provided an ultrasonic drug delivery method and an ultrasonic drug delivery apparatus each capable of performing more localized and efficient drug-delivery with the aid of ultrasonic irradiation under static pressure, which increases the effect of drug delivery to deep tissue parts in treatment by ultrasonic irradiation to a living body for delivery of drugs such as nucleic acids (such as DNA, RNA, decoys, and RNAi), proteins and pharmaceutical compounds, and there is also provided a medical diagnostic imaging apparatus.
摘要翻译： 根据本发明，提供了一种超声药物输送方法和超声药物输送装置，其能够在静压下借助超声波照射进行更局部有效的药物输送，这增加了药物输送到深度的作用 通过超声波照射到用于输送诸如核酸（例如DNA，RNA，诱饵和RNAi）的药物的生物体的组织部件，蛋白质和药物化合物，并且还提供了医疗诊断成像装置。
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公开(公告)号：US20070066935A1
公开(公告)日：2007-03-22
申请号：US10555925
申请日：2004-04-30
申请人： Ryuichi Morishita , Naruya Tomita , Yasuo Kunugiza , Yoshiaki Taniyama , Hiromi Koike , Haruhide Udagawa , Tatsuo Kimura
发明人： Ryuichi Morishita , Naruya Tomita , Yasuo Kunugiza , Yoshiaki Taniyama , Hiromi Koike , Haruhide Udagawa , Tatsuo Kimura
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61K38/1833 , A61K48/00
摘要： The present invention provides a needleless syringe having, accommodated therein, a pharmaceutical preparation containing genes and/or analogues thereof. A needleless syringe comprising: a medical agent chamber 22 having one or multiple nozzle bore(s) 25 and accommodated with a medical agent L, and a syringe main body 12 being provided with pressure application means 32 to apply pressure on the medical agent L toward a direction of the nozzle bore(s) 25 and effect emission of the medical agent L through the nozzle bore(s) 25, wherein the medical agent L is a pharmaceutical preparation containing genes and/or analogues thereof. Examples of the medical agent L include pharmaceutical preparation containing HGF gene and pharmaceutical preparation containing NF-κB decoy oligonucleotide.
摘要翻译： 本发明提供一种无针注射器，其中容纳有含有其基因和/或类似物的药物制剂。 一种无针注射器，包括：药剂腔室22，其具有一个或多个喷嘴孔25并且容纳有药剂L;以及注射器主体12，其设有施加压力的压力施加装置32，以对药剂L施加压力 喷嘴孔25的方向并且通过喷嘴孔25发射药剂L，其中药剂L是含有其基因和/或类似物的药物制剂。 药剂L的实例包括含有HGF基因的药物制剂和含有NF-κB诱饵寡核苷酸的药物制剂。
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公开(公告)号：US06989374B1
公开(公告)日：2006-01-24
申请号：US09857719
申请日：2000-10-05
CPC分类号： A61K48/005 , A61K9/127 , A61K38/1833 , A61K48/00 , A61K48/0083
摘要： This invention enables the repair of cardiac function by noninvasive administration of an HGF gene in the form of Sendai virus (HVJ)-liposome into the affected cardiac muscle, thereby inducing angiogenesis of the cardiac muscle layer and repressing fibrosis.
摘要翻译： 本发明能够通过非侵入性地将仙台病毒（HVJ） - 脂质体形式的HGF基因侵入受影响的心肌来维持心脏功能，从而诱导心肌层的血管生成并抑制纤维化。
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9.发明申请Compositions for delivering biologically active drug and method of using the same 审中-公开用于递送生物活性药物的组合物及其使用方法公开(公告)号：US20050147589A1
公开(公告)日：2005-07-07
申请号：US10508554
申请日：2002-03-22
CPC分类号： A61K9/0009
摘要： A composition for delivering a biologically active agent to a specific site in the living body comprises microbubble-encapsulated albumin microspheres containing perfluorocarbon. The biologically active agent is preferably at least one agent selected from the group consisting of oligonucleotides, antisense oligonucleotides, triple helix-forming oligonucleotides, oligonucleotide probes, nucleotide vectors, viral vectors, and plasmids. When the composition is used, the specific site is exposed to ultrasound so that the biologically active agent can be incorporated in the specific site.
摘要翻译： 用于将生物活性剂递送到生物体中的特定部位的组合物包含含有全氟化碳的微泡包封的白蛋白微球。 生物活性剂优选为选自由寡核苷酸，反义寡核苷酸，三螺旋形成寡核苷酸，寡核苷酸探针，核苷酸载体，病毒载体和质粒组成的组中的至少一种。 当使用组合物时，将特定部位暴露于超声波中，使得生物活性剂可以并入特定部位。
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10.发明授权Flake- or sliver-like porous structure of polymeric material and process of producing same, and process of producing sheet-like structure therefrom 失效聚合材料的片状或条状多孔结构及其制造方法，以及从其生产片状结构的方法
公开(公告)号：US4146510A
公开(公告)日：1979-03-27
申请号：US609442
申请日：1975-09-02
申请人： Masahiko Miyanoki , Takeshi Uotani , Fujio Itani , Toshi Yoshihara , Masayuki Igawa , Munehiro Okumura , Syoji Imao , Yoshiaki Taniyama
发明人： Masahiko Miyanoki , Takeshi Uotani , Fujio Itani , Toshi Yoshihara , Masayuki Igawa , Munehiro Okumura , Syoji Imao , Yoshiaki Taniyama
CPC分类号： D01D5/11 , C08J9/0066 , Y10S264/05 , Y10S264/17
摘要： Flake- or sliver-like porous structures of a polymeric material heavily loaded with a finely divided inorganic substance are prepared by spurting a mixture of the polymeric and finely divided inorganic components in a solvent. The products have many fine, irregular voids. The thickness of walls forming such voids is 5.mu. or less. The products are especially useful for producing sheet-like structures therefrom by beating and/or refining them followed by general paper making procedures. The sheets, when calendered, have a high initial modulus and improved dimensional stability.
摘要翻译： 通过在溶剂中喷射聚合物和细碎无机组分的混合物来制备重度负载有细碎无机物质的聚合材料的片状或条形状的多孔结构。 该产品有许多细小的，不规则的空隙。 形成这种空隙的壁的厚度为5μm以下。 该产品特别适用于通过捶打和/或精制它们，然后通过一般的造纸程序来生产片状结构。 当压延时，片材具有高初始模量和改进的尺寸稳定性。
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