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    Midkine inhibitory compositions for the treatment of angiostenosis
    3.
    发明授权
    Midkine inhibitory compositions for the treatment of angiostenosis 有权
    用于治疗血管狭窄的中期抑制组合物

    公开(公告)号：US07820160B2

    公开(公告)日：2010-10-26

    申请号：US11936438

    申请日：2007-11-07

    申请人： Kenji Kadomatsu ,  Mitsuru Horiba ,  Takashi Muramatsu ,  Shinya Ikematsu ,  Sadatoshi Sakuma

    发明人： Kenji Kadomatsu ,  Mitsuru Horiba ,  Takashi Muramatsu ,  Shinya Ikematsu ,  Sadatoshi Sakuma

    IPC分类号： A61K39/395 ,  A61K48/00

    CPC分类号： C12N15/1136 ,  A61K2039/505 ,  C07K14/475 ,  C07K16/22 ,  C12N15/1137 ,  C12N15/1138

    摘要： The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues as an effective ingredient. The present invention is useful for the prevention or treatment of angiostenosis attributed to arteriosclerosis or restenosis after percutaneous transluminal coronary angioplasty (PTCA). As compounds inhibiting the function of MK, antisense oligonucleotides that bind to a segment of a single-stranded mRNA transcribed from the MK gene to inhibit the synthesis of MK protein in cells, antibodies against the MK protein, and such can be used.

    摘要翻译： 本发明提供了一种用于预防或治疗血管狭窄症的药物组合物，其包含抑制血管组织中的中期因子（MK）作为有效成分的功能的化合物。 本发明可用于预防或治疗经皮腔内冠状动脉血管成形术（PTCA）后动脉硬化或再狭窄引起的血管狭窄。 作为抑制MK功能的化合物，可以使用结合从MK基因转录的单链mRNA片段抑制细胞中MK蛋白合成的抗体的反义寡核苷酸等。

    Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same
    6.
    发明授权
    Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
    N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA

    公开(公告)号：US6037159A

    公开(公告)日：2000-03-14

    申请号：US263023

    申请日：1999-03-05

    申请人： Kenji Uchimura ,  Hideki Muramatsu ,  Kenji Kadomatsu ,  Reiji Kannagi ,  Osami Habuchi ,  Takashi Muramatsu

    发明人： Kenji Uchimura ,  Hideki Muramatsu ,  Kenji Kadomatsu ,  Reiji Kannagi ,  Osami Habuchi ,  Takashi Muramatsu

    IPC分类号： C12N15/09 ,  C07K16/28 ,  C07K16/44 ,  C12N9/10 ,  C12N15/54 ,  C12P19/04 ,  C12P19/26 ,  C12R1/91

    CPC分类号： C07K16/2896 ,  C07K16/44 ,  C12N9/13 ,  C12P19/04

    摘要： Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below:(a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or(b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I:GlcNAc.beta.1-3Gal.beta.1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, .beta.1-3 represents a .beta.1-3 glycosidic linkage, and .beta.1-4 represents a .beta.1-4 glycosidic linkage.

    摘要翻译： 提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。 多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性 供体位于位于由式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基的6位的羟基：GlcNAcβ1〜3Galβ1-4GlcNAc（I），其中GlcNAc表示N-乙酰氨基葡萄糖残基 Gal代表半乳糖残基，β1-3代表β1-3糖苷键，β1-4代表β1-4糖苷键。

    POLYPEPTIDE OF N-ACETYLGLUCOSAMINE-6-O-SULFOTRANSFERASE AND DNA ENCODING THE SAME
    8.
    发明申请
    POLYPEPTIDE OF N-ACETYLGLUCOSAMINE-6-O-SULFOTRANSFERASE AND DNA ENCODING THE SAME 有权
    N-乙酰氨基葡萄糖-6-磷脂酰肌醇蛋白多糖和编码其的DNA

    公开(公告)号：US20100137564A1

    公开(公告)日：2010-06-03

    申请号：US12194441

    申请日：2008-08-19

    申请人： Kenji Uchimura ,  Hideki Muramatsu ,  Kenji Kadomatsu ,  Reiji Kannagi ,  Osami Habuchi ,  Takashi Muramatsu

    发明人： Kenji Uchimura ,  Hideki Muramatsu ,  Kenji Kadomatsu ,  Reiji Kannagi ,  Osami Habuchi ,  Takashi Muramatsu

    IPC分类号： C07K16/44

    CPC分类号： C07K16/2896 ,  C07K16/44 ,  C12N9/13 ,  C12P19/04

    摘要： A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide having the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which includes an amino acid sequence including substitution, deletion, insertion or transposition of one or a few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented the formula I: GlcNAcβ1-3Galβ1-4GlcNAc  (I) where GlcNAc represents an N-acetyl-glucosamine residue, Gal represents a galactose residue, β 1-3 represents a β 1-3 glycosidic linkage, and β 1-4 represents a β 1-4 glycosidic linkage.

    摘要翻译： 提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。 多肽为（a）或（b）：（a）具有SEQ ID NO：2所示氨基酸序列的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸盐转移硫酸基的酶活性 给予位于寡糖的非还原末端的N-乙酰葡糖胺残基6位的羟基，代表式I：GlcNAc＆bgr; 1-3Gal＆bgr; 1-4GlcNAc（I），其中GlcNAc代表N-乙酰基 - 葡萄糖胺残基，Gal表示半乳糖残基， 1-3代表一个 1-3糖苷键，和bgr; 1-4代表一个 1-4糖苷键。