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公开(公告)号：US20060009439A1
公开(公告)日：2006-01-12
申请号：US10515647
申请日：2003-05-29
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/33
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号：US20060241171A1
公开(公告)日：2006-10-26
申请号：US11473201
申请日：2006-06-23
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/365 , C07D313/04 , C07D405/02
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中R 3，R 6，R 7和R 7， SUP> 21个彼此相同或不同，各自表示羟基等），其药理学上可接受的盐或它们的水合物。 本发明的化合物（I）抑制血管生成，特别是在缺氧条件下抑制VEGF的产生，可用作治疗实体癌的治疗剂。
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公开(公告)号：US07893068B2
公开(公告)日：2011-02-22
申请号：US11927564
申请日：2007-10-29
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/496 , A61K31/365 , C07D313/00 , C07D405/12 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/10
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中R3，R6，R7和R21彼此相同或不同，各自表示羟基等），其药理学上可接受的盐或 它们的水合物。 本发明的化合物（I）抑制血管生成，特别是在缺氧条件下抑制VEGF的产生，可用作治疗实体癌的治疗剂。
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公开(公告)号：US20080275059A1
公开(公告)日：2008-11-06
申请号：US11927542
申请日：2007-10-29
申请人： Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/496 , C07D313/00 , C07D405/12 , A61P19/02 , A61P35/04 , A61P29/00 , A61P35/00 , A61P9/10 , A61K31/365
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中R 3，R 6，R 7和R 7， SUP> 21个彼此相同或不同，各自表示羟基等），其药理学上可接受的盐或它们的水合物。 本发明的化合物（I）抑制血管生成，特别是在缺氧条件下抑制VEGF的产生，可用作治疗实体癌的治疗剂。
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公开(公告)号：US07619100B2
公开(公告)日：2009-11-17
申请号：US11927542
申请日：2007-10-29
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： C07D313/00 , C07D313/04
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号：US07550503B2
公开(公告)日：2009-06-23
申请号：US11473201
申请日：2006-06-23
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A01N43/02 , A61K31/335 , C07D313/00 , C07D313/04
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中R3，R6，R7和R21彼此相同或不同，各自表示羟基等），其药理学上可接受的盐或 它们的水合物。 本发明的化合物（I）抑制血管生成，特别是在缺氧条件下抑制VEGF的产生，可用作治疗实体癌的治疗剂。
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公开(公告)号：US20080255146A1
公开(公告)日：2008-10-16
申请号：US11927564
申请日：2007-10-29
申请人： Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/496 , C07D313/00 , A61K31/365 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/10 , C07D405/12
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号：USD314005S
公开(公告)日：1991-01-22
申请号：US277951
申请日：1988-11-30
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