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4 条记录 (耗时 0.032 秒)

    Receptor
    3.
    发明授权
    Receptor 失效
    受体

    公开(公告)号：US06545137B1

    公开(公告)日：2003-04-08

    申请号：US09060299

    申请日：1998-04-15

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    IPC分类号： C07H2104

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

    LDL-receptor
    4.
    发明授权
    LDL-receptor 有权
    LDL受体

    公开(公告)号：US06555654B1

    公开(公告)日：2003-04-29

    申请号：US09402923

    申请日：2000-02-14

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。