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6 条记录 (耗时 0.057 秒)

    Receptor
    1.
    发明授权
    Receptor 失效
    受体

    公开(公告)号：US06545137B1

    公开(公告)日：2003-04-08

    申请号：US09060299

    申请日：1998-04-15

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    IPC分类号： C07H2104

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

    LDL-receptor
    3.
    发明授权
    LDL-receptor 有权
    LDL受体

    公开(公告)号：US06555654B1

    公开(公告)日：2003-04-29

    申请号：US09402923

    申请日：2000-02-14

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

    DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
    6.
    发明授权
    DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats 失效
    具有短串联重复多态性的DNA分型和多态性短串联重复的鉴定

    公开(公告)号：US5364759A

    公开(公告)日：1994-11-15

    申请号：US647655

    申请日：1991-01-31

    申请人： Charles T. Caskey ,  Albert O. Edwards

    发明人： Charles T. Caskey ,  Albert O. Edwards

    IPC分类号： C12Q1/68 ,  C07H15/12 ,  G01N33/48 ,  G01N33/566

    CPC分类号： C12Q1/6876 ,  C12Q1/6858 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00722 ,  C12Q2600/156 ,  C12Q2600/16 ,  Y10S435/81 ,  Y10T436/143333

    摘要： The present invention relates to a DNA profiling assay for detecting polymorphisms in a short tandem repeat. The method includes the steps of extracting DNA from a sample to be tested, amplifying the extracted DNA and identifying the amplified extension products for each different sequence. Each different sequence is differentially labeled. In the method, internal and external standards can also be used. The method is applicable to a wide variety of forensic and medical samples, including blood, semen, vaginal swaps, tissue, hair, saliva, urine and mixtures of body fluids. A short tandem repeat sequence which can be characterized by the formula (A.sub.w G.sub.x T.sub.y C.sub.z).sub.n, wherein A, G, T and C represent the nucleotides, w, x, y and z represent the number of nucleotide and range from 0 to 7 and the sum of w+x+y+z ranges from 3 to 7 and n represents the repeat number and ranges from 5 to 50. The labels can be from a variety of groups, including fluorescers, radioisotopes, chemiluminescers, stains, enzymes and antibodies. Also described is a kit. Further, a method of detecting the polymorphic short tandem repeats comprising the steps of either searching for the repeats in a data base or comparing oligonucleotides and searching for the repeats in a genetic library.

    摘要翻译： 本发明涉及用于检测短串联重复序列中的多态性的DNA构象测定法。 该方法包括从待测样品中提取DNA，扩增提取的DNA并鉴定每个不同序列的扩增扩增产物的步骤。 每个不同的序列是差异标记的。 在该方法中，也可以使用内部和外部标准。 该方法适用于各种法医和医学样品，包括血液，精液，阴道交换，组织，头发，唾液，尿液和体液混合物。 可以通过式（AwGxTyCz）n表征的短串联重复序列，其中A，G，T和C表示核苷酸，w，x，y和z表示核苷酸的数目，范围为0至7，总和 w + x + y + z范围为3至7，n表示重复数，范围为5至50.标签可以来自多种基团，包括荧光剂，放射性同位素，化学发光剂，污渍，酶和抗体。 还描述了一个工具包。 此外，检测多态性短串联重复的方法包括以下步骤：在数据库中搜索重复序列或比较寡核苷酸并在遗传图谱库中搜索重复序列。