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19 条记录 (耗时 0.052 秒)

    Receptor
    1.
    发明授权
    Receptor 失效
    受体

    公开(公告)号：US06545137B1

    公开(公告)日：2003-04-08

    申请号：US09060299

    申请日：1998-04-15

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C.J. Twells

    IPC分类号： C07H2104

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

    LDL-receptor
    3.
    发明授权
    LDL-receptor 有权
    LDL受体

    公开(公告)号：US06555654B1

    公开(公告)日：2003-04-29

    申请号：US09402923

    申请日：2000-02-14

    申请人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    发明人： John A. Todd ,  John W. Hess ,  Charles T. Caskey ,  Roger D Cox ,  David Gerhold ,  Holly Hammond ,  Patricia Hey ,  Yoshihiko Kawaguchi ,  Tony R. Merriman ,  Michael L. Metzker ,  Yusuke Nakagawa ,  Michael S. Phillips ,  Rebecca C. J. Twells

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

    摘要翻译： 提供了新的受体“LDL-受体相关蛋白-3”（“LRP-3”）以及编码核酸。 该基因与1型糖尿病（胰岛素依赖性糖尿病）相关，实验证据表明其是IDDM易感基因IDDM4。 在各个方面，本发明提供核酸，包括编码序列，寡核苷酸引物和探针，多肽，药物组合物，诊断或预后的方法，以及与该基因相关并基于该基因的其它方法，包括治疗其中基因 可能涉及自身免疫性疾病，例如肾小球性肾炎，涉及细胞内吞和/或抗原呈递破坏的疾病和病症，涉及细胞因子清除和/或炎症的疾病和病症，病毒感染，游离脂肪酸升高或高胆固醇血症，骨质疏松症，阿尔茨海默病 疾病和糖尿病。

    Filter change liquid shutoff safety interlock device
    5.
    发明授权
    Filter change liquid shutoff safety interlock device 失效
    过滤器切换液体关闭安全联锁装置

    公开(公告)号：US5101850A

    公开(公告)日：1992-04-07

    申请号：US430551

    申请日：1989-11-01

    申请人： John A. Todd

    发明人： John A. Todd

    IPC分类号： B01D35/153

    CPC分类号： B01D35/153 ,  Y10T137/0486 ,  Y10T137/794

    摘要： A liquid shutoff safety interlock device is provided which ensures that fluid flow to a filter is stopped prior to filter removal without requiring the use of a complex and expensive filter valve assembly and without requiring any substantial modification of existing components. The invention is particularly, though not exclusively, adapted to fuel dispensing equipment supplied by a remote pump and installed with a filter above and an impact valve below each fluid supply inlet. The liquid shutoff safety device of the present invention is placed between the impact valve and the filter so that in one position the device blocks access to the end of the filter and in another position provides filter access while at the same time tripping the latch arm to close the impact valve.

    摘要翻译： 提供了一种液体截止安全联锁装置，其确保在过滤器移除之前停止流向过滤器的流体，而不需要使用复杂和昂贵的过滤阀组件，并且不需要对现有部件进行任何实质的修改。 本发明特别地但不排他地适用于由远程泵供应的燃料分配设备，并且在每个流体供应入口下方安装有过滤器和冲击阀。 本发明的液体关闭安全装置被放置在冲击阀和过滤器之间，使得在一个位置中，装置阻挡对过滤器端部的接近，并且在另一位置提供过滤器进入，同时使闩锁臂跳到 关闭冲击阀。

    Multiple product gasoline dispenser
    6.
    发明授权
    Multiple product gasoline dispenser 失效
    多产品汽油分配器

    公开(公告)号：US4223807A

    公开(公告)日：1980-09-23

    申请号：US10294

    申请日：1979-02-08

    申请人： Richard L. Caswell ,  John A. Todd

    发明人： Richard L. Caswell ,  John A. Todd

    IPC分类号： B67D7/08 ,  B67D5/08

    CPC分类号： B67D7/08

    摘要： Customer dispensing of either unleaded or one of two or more grades of leaded gasoline products is selected by rotatable selector knobs located on the dispenser housing. Individual meters are operative by the leaded and unleaded dispensing systems which are hydraulically isolated from each other. The separate selector knobs are associated with each of the leaded and unleaded dispensing systems and are effective when actuated to render the other system inoperative by an imposed mechanical interlock. Bothe meters operate a common computers for calculating the transaction data of each dispensing sale.

    摘要翻译： 通过位于分配器壳体上的可旋转选择旋钮选择无铅或两种或更多级别的含铅汽油产品的客户分配。 单独的仪表由通过液压隔离的有铅和无铅分配系统操作。 单独的选择器旋钮与每个有铅和无铅分配系统相关联，并且当被致动以使另一个系统由施加的机械互锁不起作用时是有效的。 Bothe仪表操作常用的计算机，用于计算每个分销销售的交易数据。

    Leak detection system and method for fluid delivery piping
    7.
    发明授权
    Leak detection system and method for fluid delivery piping 失效
    流体输送管道泄漏检测系统和方法

    公开(公告)号：US4131216A

    公开(公告)日：1978-12-26

    申请号：US791812

    申请日：1977-04-28

    申请人： William J. Gerstenmaier ,  John A. Todd

    发明人： William J. Gerstenmaier ,  John A. Todd

    IPC分类号： B67D7/06 ,  G01M3/28 ,  B67D5/14

    CPC分类号： B67D7/06 ,  G01M3/2892

    摘要： A system and method for detecting leaks in an underground piping network supplying liquid petroleum products pumped from an underground storage tank to an aboveground dispenser outlet. A highly sensitive flow detector situated in a parallel looped bypass arrangement is selectively operated for ascertaining existence or non-existence of a piping leak. Following a sufficient time lapse of non-dispensing for enabling temperature stabilization of the piping network to occur, the detector is actuated in a controlled sequence of go, no-go steps that culminates in ascertaining existence or non-existence of a piping leak while at the same time eliminating any false indication occasioned by detector malfunction.

    摘要翻译： 一种用于检测地下管网中泄漏的系统和方法，该地下管道网络将从地下储罐泵送的液化石油产品供应到地上分配器出口。 选择性地操作位于并联环路旁路装置中的高灵敏度流量检测器，以确定管道泄漏的存在或不存在。 经过足够的不分配时间后，可以实现管网的温度稳定化，检测器以受控制的顺序执行，最终确定管道泄漏的存在或不存在，同时在 同时消除由检测器故障引起的任何错误指示。

    Vapor guard for vapor recovery system
    10.
    发明授权
    Vapor guard for vapor recovery system 失效
    蒸汽回收系统的蒸汽防护装置

    公开(公告)号：US5365985A

    公开(公告)日：1994-11-22

    申请号：US154770

    申请日：1993-11-18

    申请人： John A. Todd ,  William H. Constantine

    发明人： John A. Todd ,  William H. Constantine

    IPC分类号： B67D7/42 ,  B67D7/54 ,  B65B3/00

    CPC分类号： B67D7/421 ,  B67D7/54

    摘要： A vapor guard mounted on a gasoline dispenser nozzle includes a collapsible resilient section which provides a limited expansion force enabling the use of a standard gasoline dispenser retainer spring to catch on the vehicle fill pipe flange for hands-free fuel dispensing and straight-pull removal. The expansion force of the collapsible resilient section also is limited to ensure the existence of non-sealing contact between the end of the vapor guard and the fill pipe flange. The vapor guard is sized and positioned on the dispenser to enable the user to see the end of the nozzle as it is inserted into the vehicle fill pipe and aligned with a nozzle port in a restricter plate located in the fill pipe.

    摘要翻译： 安装在汽油分配器喷嘴上的蒸汽保护罩包括可折叠的弹性部分，其提供有限的膨胀力，使得能够使用标准汽油分配器固定弹簧来抓住车辆填充管法兰上，以实现免提燃料分配和直拉除去。 可折叠弹性部分的膨胀力也受到限制，以确保在防护罩的端部与填充管法兰之间存在非密封接触。 蒸汽护罩的尺寸和位置在分配器上，以使使用者能够在喷嘴插入车辆填充管时看到喷嘴的端部，并与位于填充管中的限制器板中的喷嘴端口对齐。