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公开(公告)号：US07912267B2
公开(公告)日：2011-03-22
申请号：US12620268
申请日：2009-11-17
IPC分类号： G06K9/00
CPC分类号： G06K9/2009 , G02B21/34 , G02B21/36 , Y10S128/922
摘要： The present invention is a virtual-slide specimen image acquisition apparatus that captures images by dividing a specimen into a plurality of sections, having a conveying device in which a plurality of specimens can be arranged and that conveys the plurality of the arranged specimens in a first direction by a distance corresponding to the length of a side along the first direction in one of the divided sections and at first time intervals and an image capturing device that has an image capturing portion for capturing images of the specimens magnified at a predetermined magnification and that scans the specimens conveyed to a predetermined position in a second direction, by a predetermined length at second time intervals, such that the image capturing portion captures images of all of the sections that are positioned identically in the first direction and that are positioned differently in the second direction perpendicular to the first direction.
摘要翻译： 本发明是一种虚拟幻灯片样本图像获取装置，其通过将样本分割成多个部分来捕获图像，该多个部分具有其中可以布置多个样本的输送装置，并且将多个排列的样本以第一 在一个分割部分中以第一时间间隔对应于沿着第一方向的一侧的长度的方向的方向和具有用于捕获以预定倍数放大的样本的图像的图像捕获部分的图像捕获装置，以及 以第二时间间隔将传送到第二方向的预定位置的样本扫描预定长度，使得图像捕获部分捕获在第一方向上相同位置并且在第二方向上不同定位的所有部分的图像 第二方向垂直于第一方向。
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公开(公告)号：US07564621B2
公开(公告)日：2009-07-21
申请号：US11975385
申请日：2007-10-18
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US20080049215A1
公开(公告)日：2008-02-28
申请号：US11975385
申请日：2007-10-18
IPC分类号： G01N21/00
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US07301626B2
公开(公告)日：2007-11-27
申请号：US11182782
申请日：2005-07-18
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。
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公开(公告)号：US20070028918A1
公开(公告)日：2007-02-08
申请号：US11498474
申请日：2006-08-02
IPC分类号： A61M15/00
摘要： The present invention prevents the leakage of anesthetic gas, and enables in vivo observation of a specimen such as small laboratory animals over a long period of time. An anesthetizing chamber comprises a chamber main body for housing a specimen such as a laboratory animal; an anesthetic gas supply part for supplying anesthetic gas to the chamber main body; and an anesthetic gas recovery part for recovering the anesthetic gas that is supplied into the chamber main body from the anesthetic gas supply part; wherein a transparent window is provided to at least the chamber main body.
摘要翻译： 本发明防止了麻醉气体的泄漏，并且能够长时间地在小型实验动物体内观察样本。 麻醉室包括用于容纳诸如实验动物的样本的室主体; 用于向室主体供给麻醉气体的麻醉气体供给部; 以及麻醉气体回收部，其用于回收从所述麻醉气体供给部供给到所述室主体的麻醉气体; 其中，透明窗口至少设置在所述室主体上。
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公开(公告)号：US5777783A
公开(公告)日：1998-07-07
申请号：US799865
申请日：1997-02-14
申请人： Itaru Endou , Yasushi Kaneko , Yoshihiro Kawano , Kazuo Kajitani
发明人： Itaru Endou , Yasushi Kaneko , Yoshihiro Kawano , Kazuo Kajitani
CPC分类号： G02B21/36
摘要： A microscope has an optical system in which the number of photographing optical paths can be increased. The optical system includes a light source, an illuminating optical system for radiating the illuminating light to a sample, an objective lens which is opposed to the sample, an imaging lens, which is arranged in an optical path of light passed through the objective lens, a first beam splitting block, arranged in an optical path between the objective lens and the primary image, for splitting the light passed through the imaging lens into at least three different directions, a second beam splitting block for splitting one of the light split by the first beam splitting block into a plurality of directions, an observation optical path which receives the light split by the second beam splitting block, and a plurality of photographing optical paths provided for the split light, wherein images of the same magnification are formed.
摘要翻译： 显微镜具有可以增加拍摄光路数量的光学系统。 光学系统包括光源，用于将照明光照射到样本的照明光学系统，与样本相对的物镜，配置在通过物镜的光的光路中的成像透镜， 第一分束块，布置在物镜和主图像之间的光路中，用于将通过成像透镜的光分成至少三个不同的方向;第二光束分割块，用于将光分离的光 第一分束块分成多个方向，接收由第二分束块分割的光的观察光路，以及为分裂光设置的多个摄影光路，其中形成相同倍率的图像。
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公开(公告)号：US5212375A
公开(公告)日：1993-05-18
申请号：US772243
申请日：1991-10-07
申请人： Hisashi Goto , Tsutomu Uzawa , Yoshihiro Kawano , Hiroyuki Kurita , Hideaki Yoshida , Akira Hasegawa , Kimihiko Nishioka
发明人： Hisashi Goto , Tsutomu Uzawa , Yoshihiro Kawano , Hiroyuki Kurita , Hideaki Yoshida , Akira Hasegawa , Kimihiko Nishioka
CPC分类号： G02B5/32 , G02B7/28 , G03B7/09972 , G03B7/09976
摘要： An imaging system having a focus detecting device performs focus detection by detecting an output signal indicative of intensity distribution of light derived from a light-receiving element, in which at least one holographic optical element is arranged on the object side of a primary imaging plane to form an image on the light-receiving element. Thus, the imaging system has significant advantages in practical use that the arrangement is simple and the camera body is made compact.
摘要翻译： 具有焦点检测装置的成像系统通过检测指示从光接收元件导出的光的强度分布的输出信号来执行焦点检测，其中至少一个全息光学元件被布置在主成像平面的物体侧， 在光接收元件上形成图像。 因此，成像系统在实际应用中具有显着的优点，即布置简单，并且相机体紧凑。
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公开(公告)号：US20100128962A1
公开(公告)日：2010-05-27
申请号：US12620268
申请日：2009-11-17
IPC分类号： G06K9/00
CPC分类号： G06K9/2009 , G02B21/34 , G02B21/36 , Y10S128/922
摘要： The present invention is a virtual-slide specimen image acquisition apparatus that captures images by dividing a specimen into a plurality of sections, having a conveying device in which a plurality of specimens can be arranged and that conveys the plurality of the arranged specimens in a first direction by a distance corresponding to the length of a side along the first direction in one of the divided sections and at first time intervals and an image capturing device that has an image capturing portion for capturing images of the specimens magnified at a predetermined magnification and that scans the specimens conveyed to a predetermined position in a second direction, by a predetermined length at second time intervals, such that the image capturing portion captures images of all of the sections that are positioned identically in the first direction and that are positioned differently in the second direction perpendicular to the first direction.
摘要翻译： 本发明是一种虚拟幻灯片样本图像获取装置，其通过将样本分割成多个部分来捕获图像，该多个部分具有其中可以布置多个样本的输送装置，并且将多个排列的样本以第一 在一个分割部分中以第一时间间隔对应于沿着第一方向的一侧的长度的方向的方向和具有用于捕获以预定倍数放大的样本的图像的图像捕获部分的图像捕获装置，以及 以第二时间间隔将传送到第二方向的预定位置的样本扫描预定长度，使得图像捕获部分捕获在第一方向上相同位置并且在第二方向上不同定位的所有部分的图像 第二方向垂直于第一方向。
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公开(公告)号：US07616292B2
公开(公告)日：2009-11-10
申请号：US11648638
申请日：2007-01-03
申请人： Susumu Kikuchi , Yoshihiro Kawano , Masahiro Oba
发明人： Susumu Kikuchi , Yoshihiro Kawano , Masahiro Oba
IPC分类号： G01C11/12
CPC分类号： G01N21/6458 , A61B5/14556 , G01N21/6428 , G01N21/6486 , G01N2021/1787 , G02B21/365
摘要： The invention provides an examination apparatus including an objective optical system for positioning a focal point inside a specimen mounted on a stage; an image-acquisition apparatus for detecting light emitted in different optical-axis directions from the vicinity of the focal point inside the specimen and collected by the objective optical system to acquire a plurality of pieces of image information; and a three-dimensional image forming unit for forming a three-dimensional image of a light-emitting site in the vicinity of the focal point based on the plurality of pieces of image information acquired by the image-acquiring apparatus.
摘要翻译： 本发明提供了一种检查装置，其包括用于将焦点定位在安装在台架上的样本内的物镜光学系统; 用于从所述物体光学系统收集的，从所述样本内的所述焦点附近检测在不同的光轴方向上发出的光的摄像装置，以获取多张图像信息; 以及三维图像形成单元，用于基于由图像获取装置获取的多条图像信息，在焦点附近形成发光位置的三维图像。
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公开(公告)号：US20070247523A1
公开(公告)日：2007-10-25
申请号：US11648638
申请日：2007-01-03
申请人： Susumu Kikuchi , Yoshihiro Kawano , Masahiro Oba
发明人： Susumu Kikuchi , Yoshihiro Kawano , Masahiro Oba
IPC分类号： H04N13/02
CPC分类号： G01N21/6458 , A61B5/14556 , G01N21/6428 , G01N21/6486 , G01N2021/1787 , G02B21/365
摘要： The invention provides an examination apparatus including an objective optical system for positioning a focal point inside a specimen mounted on a stage; an image-acquisition apparatus for detecting light emitted in different optical-axis directions from the vicinity of the focal point inside the specimen and collected by the objective optical system to acquire a plurality of pieces of image information; and a three-dimensional image forming unit for forming a three-dimensional image of a light-emitting site in the vicinity of the focal point based on the plurality of pieces of image information acquired by the image-acquiring apparatus.
摘要翻译： 本发明提供了一种检查装置，其包括用于将焦点定位在安装在台架上的样本内的物镜光学系统; 用于从所述物体光学系统收集的，从所述样本内的所述焦点附近检测在不同的光轴方向上发出的光的摄像装置，以获取多张图像信息; 以及三维图像形成单元，用于基于由图像获取装置获取的多条图像信息，在焦点附近形成发光位置的三维图像。
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