公开(公告)号：US20050107604A1

公开(公告)日：2005-05-19

申请号：US10505906

申请日：2003-01-10

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

IPC: G01N21/77 ,  C07D487/22 ,  C07D519/00 ,  C07F3/02 ,  G01N21/19 ,  G01N33/00

CPC classification number: C07D519/00 ,  G01N21/19 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/20

Abstract: The present invention relates to a reagent for determining the absolute configuration of a chiral compound containing as an active ingredient a metalloporphyrin dimer, wherein the metalloporphyrin dimer has an alkaline-earth metal ion as a central metal and has a carbon chain-crosslinked structure in which at least one of the two porphyrin rings has a substituent bulkier than methyl at at least one of the second carbon atoms from a carbon atom bonded to the crosslinking carbon chain along the outer periphery of the porphyrin ring and a method for determining the absolute configuration of an asymmetric carbon atom of the chiral compound using the reagent.

Abstract translation: 本发明涉及一种用于测定含有金属卟啉二聚体作为活性成分的手性化合物的绝对构型的试剂，其中金属卟啉二聚体具有碱土金属离子作为中心金属并具有碳链交联结构，其中 两个卟啉环中的至少一个在与卟啉环的外周键合到交联碳链上的碳原子的至少一个第二碳原子上具有比甲基更大的取代基，并且确定绝对构型的方法 使用该试剂的手性化合物的不对称碳原子。

公开(公告)号：US06420553B1

公开(公告)日：2002-07-16

申请号：US09646448

申请日：2000-10-31

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

IPC: C07D48722

CPC classification number: C07D487/22 ,  C07D519/00

Abstract: A process for producing a metalloporphyrin containing a transition metal inserted into the porphyrin ring which comprises dissolving a porphyrin compound and a transition metal salt each in an independent solvent, combining the solutions, and carrying out the reaction in the presence of a basic substance. By this process a metalloporphyrin containing a transition metal inserted into the porphyrin ring can be synthesized easily under mild conditions and with high selectivity.

Abstract translation: 一种制备含有插入到卟啉环中的过渡金属的金属卟啉的方法，其包括将卟啉化合物和过渡金属盐各自溶解在独立的溶剂中，将该溶液混合，并在碱性物质的存在下进行反应。 通过该方法，可以在温和条件下以高选择性容易地合成含有插入卟啉环中的过渡金属的金属卟啉。

公开(公告)号：US07648841B2

公开(公告)日：2010-01-19

申请号：US10505906

申请日：2003-01-10

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

IPC: G01N33/00 ,  C07D487/22

CPC classification number: C07D519/00 ,  G01N21/19 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/20

Abstract: The present invention relates to a reagent for determining the absolute configuration of a chiral compound containing as an active ingredient a metalloporphyrin dimer, wherein the metalloporphyrin dimer has an alkaline-earth metal ion as a central metal and has a carbon chain-crosslinked structure in which at least one of the two porphyrin rings has a substituent bulkier than methyl at least one of the second carbon atoms from a carbon atom bonded to the crosslinking carbon chain along the outer periphery of the porphyrin ring and a method for determining the absolute configuration of an asymmetric carbon atom of the chiral compound using the reagent.

Abstract translation: 本发明涉及一种用于测定含有金属卟啉二聚体作为活性成分的手性化合物的绝对构型的试剂，其中金属卟啉二聚体具有碱土金属离子作为中心金属并具有碳链交联结构，其中 两个卟啉环中的至少一个具有比甲基更大的取代基，该取代基来自沿着卟啉环的外周键合到交联碳链的碳原子的至少一个第二碳原子，以及用于测定卟啉环的绝对构型的方法 使用该试剂的手性化合物的不对称碳原子。

公开(公告)号：US07354771B2

公开(公告)日：2008-04-08

申请号：US10148652

申请日：2000-12-04

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Juha Lintuluoto

IPC: G01N21/00

CPC classification number: C07D487/22 ,  C09B47/00 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/174614

Abstract: The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site, and (ii) analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon based on the sign of the Cotton effect. The chiral compound has an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group.

Abstract translation: 手性化合物的绝对构型通过以下方式确定：（i）将手性化合物与具有碳链交联的卟啉二聚体结构的金属卟啉配位，其中两个卟啉环中的一个至少具有至少一个乙基或取代基至少一个乙基， 在碳链交联位点处碳原子的第二外周碳原子之一，（ii）通过圆二色性分光光度法分析得到的配位化合物，以基于棉花效应的符号确定不对称碳的绝对构型。 手性化合物具有与能够与金属卟啉二聚体的另一卟啉环的金属配位的碱性基团或与键合到碱性基团的碳原子相邻的不对称碳原子键合的不对称碳。

公开(公告)号：US20060148091A1

公开(公告)日：2006-07-06

申请号：US10544496

申请日：2004-02-05

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Guy Hembury

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Guy Hembury

IPC: G01N33/00

CPC classification number: G01N21/19 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/203332

Abstract: The present invention provides a simple, highly sensitive, and highly precise method for determining the absolute configuration of a chiral compound such as a diamine or an amino alcohol. The present invention is directed to a method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy.

Abstract translation: 本发明提供了用于确定手性化合物如二胺或氨基醇的绝对构型的简单，高灵敏度和高度精确的方法。 本发明涉及一种通过分析含有手性化合物和卟啉二聚体的溶液通过圆二色光谱法测定手性化合物的不对称碳的绝对构型的方法。

公开(公告)号：US20090198454A1

公开(公告)日：2009-08-06

申请号：US12064786

申请日：2006-02-22

Applicant: Yoshihisa Inoue ,  Victor Borovkov ,  Akio Wada

Inventor： Yoshihisa Inoue ,  Victor Borovkov ,  Akio Wada

IPC: G01J1/10 ,  G06F19/00 ,  C07D487/22

CPC classification number: G01N21/278 ,  G01N21/19

Abstract: A principal object of the present invention is to provide a standard sample that allows accurate testing and calibration of a circular dichroism spectrometer, and which can also be applied to testing and calibration of a UV-visible spectrophotometer. The present invention relates to a standard sample for use in testing and/or calibrating a circular dichroism spectrometer and a UV-visible spectrophotometer, which standard sample comprising: a chlorin dimer represented by Chemical Formula (I): wherein A is CnH2n (n is an integer of 0 or more); and R1, R2, R3R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 are the same or different, and are each a hydrogen atom, a saturated hydrocarbon group, an aryl group that may be substituted, a heteroaryl group that may be substituted, or an aralkyl group that may be substituted; or a metal chlorin dimer represented by Chemical Formula (II): wherein M2+ is a divalent metal ion; and A, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 are the same as defined above. Each of the chlorin dimer and the metal chlorin dimer exhibits at least two peaks in an ultraviolet to visible region of a circular dichroism spectrum and a UV-visible absorption spectrum thereof.

Abstract translation: 本发明的主要目的是提供一种允许对圆二色性光谱仪进行精确测试和校准的标准样品，其也可应用于UV可见分光光度计的测试和校准。 本发明涉及用于测试和/或校准圆形二色性光谱仪和紫外 - 可见分光光度计的标准样品，该标准样品包含：由化学式（I）表示的二氢卟酚二聚体：其中A是C n H 2n（n是 0以上的整数）; R1，R2，R3R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15和R16可以相同或不同，分别为氢原子，饱和烃基， 可被取代的芳基，可被取代的杂芳基或可被取代的芳烷基; 或由化学式（II）表示的金属二氢卟酚二聚体：其中M2 +是二价金属离子; 并且A，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15和R16与上述定义相同。 二氢卟酚二聚物和金属二氢卟酚二聚体中的每一个在圆二色性光谱的紫外到可见区和其可见光吸收光谱中表现出至少两个峰。