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    PRODUCTION OF 2-KETO-L-GULONIC ACID
    4.
    发明申请
    PRODUCTION OF 2-KETO-L-GULONIC ACID 审中-公开
    2-KETO-L-GULONIC酸的生产

    公开(公告)号：US20120058563A1

    公开(公告)日：2012-03-08

    申请号：US13254049

    申请日：2010-03-04

    申请人： Tatsuo Hoshino ,  Nigel John Mouncey ,  Akiko Shimizu ,  Masako Shinjoh

    发明人： Tatsuo Hoshino ,  Nigel John Mouncey ,  Akiko Shimizu ,  Masako Shinjoh

    IPC分类号： C12N15/74 ,  C12N1/00 ,  C12N1/21

    CPC分类号： C12P17/04 ,  C12N9/0006 ,  C12P7/60

    摘要： The present invention relates to the production of recombinant microorganisms, in particular of the genus Gluconobacter, for production of 2-keto-L-gulonic acid (2-KGA) and/or L-ascorbic acid (hereinafter also referred to as Vitamin C), wherein the microorganism has been modified to overexpress L-sorbose dehydrogenase (SDH). This overexpression has been achieved by introducing of one or more copies of a polynucleotide encoding SDH into the genome of the host microorganism resulting in enhanced yield, production, and/or efficiency of 2-KGA production and/or Vitamin C compared to a non-modified microorganism. Expression of said one or more extra-copies of sdh is dependent on the integration site. The invention also relates to genetically engineered microorganisms and their use for the production of 2-KGA and/or Vitamin C.

    摘要翻译： 本发明涉及用于生产2-酮-L-古洛糖酸（2-KGA）和/或L-抗坏血酸（以下也称为维生素C）的重组微生物，特别是葡萄糖酸杆菌属的生产， ，其中所述微生物已被修饰以过表达L-山梨糖脱氢酶（SDH）。 通过将一个或多个编码SDH的多核苷酸的拷贝引入宿主微生物的基因组中可以实现这一过表达，导致与非特异性抗体相比，2-KGA生产和/或维生素C的产量，生产和/或效率提高， 修饰微生物。 所述一个或多个sdh副本的表达依赖于整合位点。 本发明还涉及基因工程微生物及其用于生产2-KGA和/或维生素C的用途。

    Normally white mode twisted nematic liquid crystal display device having improved viewing angle characteristics
    5.
    发明授权
    Normally white mode twisted nematic liquid crystal display device having improved viewing angle characteristics 失效
    通常具有改进的视角特性的白色模式扭曲向列型液晶显示装置

    公开(公告)号：US06208396B1

    公开(公告)日：2001-03-27

    申请号：US08957780

    申请日：1997-10-24

    申请人： Akiko Shimizu ,  Takahiro Hishinuma ,  Koji Higashi

    发明人： Akiko Shimizu ,  Takahiro Hishinuma ,  Koji Higashi

    IPC分类号： G02F11347

    CPC分类号： G02F1/133632 ,  G02F1/133634 ,  G02F2203/66

    摘要： A normally white mode twisted nematic liquid crystal display devices having significantly improved viewing angle characteristics of display contrast and gray scale inversion comprising an about 90° twisted nematic liquid crystal cell and a first and a second light polarizing film separately disposed on two sides of said liquid crystal cell, a first and a second optical compensation layer which each comprises at least one optical compensation layer and has almost no refractive index anisotropy in-plane of the optical compensation layer A and has a characteristic wherein a refractive index in the thickness direction of the optical compensation layer A is lower than that in-plane of the optical compensation layer A, and a first and second optical compensation layer B, which each comprises at least one optical compensation layer and has optically positive refractive index anisotropy and has a characteristic wherein a principal optic axis of the optical compensation layer B is tilted 20 to 70° from the normal direction of the optical compensation layer B, wherein said liquid crystal cell, said light polarizing films and said optical compensation layers A and B are laminated in the following order: said first light polarizing film, said first optical compensation layer A, said first optical compensation layer B, said liquid crystal cell, said second optical compensation layer B, said second optical compensation layer A and said second light polarizing film.

    摘要翻译： 具有显着改善的显示对比度和灰度反转的视角特性的常白模式扭曲向列型液晶显示装置，包括大约90°扭曲向列型液晶单元和分别设置在所述液体两侧的第一和第二偏光膜 晶体单元，第一和第二光学补偿层，每个光学补偿层包括至少一个光学补偿层，并且几乎不具有光学补偿层A的平面内的折射率各向异性，并且具有其特征在于，其中，厚度方向的折射率 光学补偿层A比光学补偿层A的面内低，第一和第二光学补偿层B各自包括至少一个光学补偿层，并具有光学正折射率各向异性，并且具有以下特征： 光学补偿层B的主光轴倾斜20° 光学补偿层B的法线方向为70°，其中所述液晶单元，所述光偏振膜和所述光学补偿层A和B按照以下顺序层叠：所述第一光偏移膜，所述第一光学补偿层A 所述第一光学补偿层B，所述液晶单元，所述第二光学补偿层B，所述第二光学补偿层A和所述第二光偏振膜。

    Cast molding material for plastic lens and process for the production of plastic lens
    6.
    发明授权
    Cast molding material for plastic lens and process for the production of plastic lens 有权
    用于塑料镜片的铸造材料和用于生产塑料镜片的工艺

    公开(公告)号：US06187888B1

    公开(公告)日：2001-02-13

    申请号：US09401525

    申请日：1999-09-22

    申请人： Akiko Shimizu ,  Yukio Kageyama ,  Shigeo Nakamura

    发明人： Akiko Shimizu ,  Yukio Kageyama ,  Shigeo Nakamura

    IPC分类号： C08F1824

    CPC分类号： C08F283/12 ,  G02B1/041 ,  Y10S425/808 ,  C08L31/00 ,  C08F218/16

    摘要： A cast-molding material for a plastic lens which is almost free from causing defective dyeing when dyed, and a process for producing plastic lenses almost free from causing defective dyeing, the cast-molding material containing, as essential components, a combination of (A) diethylene glycol bisallylcarbonate or a mixture of diethylene glycol bisallylcarbonate and a monomer copolymerizable therewith, with (B) a polyether-modified silicone compound, and the process comprising cast-molding the above cast-molding material in a mold.

    摘要翻译： 一种用于塑料透镜的铸塑材料，其在染色时几乎不会引起染色不良，以及用于生产几乎不引起染色不良的塑料透镜的方法，所述浇铸模塑材料作为必要组分含有（A ）二甘醇双烯丙基碳酸酯或二甘醇双烯丙基碳酸酯和可与其共聚的单体的混合物与（B）聚醚改性的硅氧烷化合物，并且该方法包括将上述浇铸成型材料浇铸成型。

    Process for making a phase retarder film
    9.
    发明授权
    Process for making a phase retarder film 失效
    制备相延迟膜的方法

    公开(公告)号：US5658505A

    公开(公告)日：1997-08-19

    申请号：US394494

    申请日：1995-02-27

    申请人： Akiko Shimizu ,  Koji Higashi

    发明人： Akiko Shimizu ,  Koji Higashi

    IPC分类号： G02B5/30 ,  B29D11/00

    CPC分类号： G02B5/3083 ,  Y10T428/24942 ,  Y10T428/31507 ,  Y10T428/31533

    摘要： A phase retarder film made of a thermoplastic resin having an in-plane retardation of 50 to 300 nm and a ratio of the in-plane retardation to the retardation normal to the plane of not less than 0.5 but not more than 1.8, a process for the production thereof and a laminate phase retarder film using said phase retarder film above.

    摘要翻译： 由面内延迟为50〜300nm的热塑性树脂制成的相位延迟膜和面内延迟与平面相位差的比例为0.5以上1.8以下的工序 使用上述相延迟膜的层压相延迟膜。