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    Ameliorant for blood lipid metabolism
    1.
    发明授权
    Ameliorant for blood lipid metabolism 失效
    改善血脂代谢

    公开(公告)号：US5527801A

    公开(公告)日：1996-06-18

    申请号：US204430

    申请日：1994-03-14

    申请人： Yoshinobu Masuda ,  Hisao Minato ,  Akihisa Ikeno ,  Kunihiko Takeyama ,  Kanoo Hosoki

    发明人： Yoshinobu Masuda ,  Hisao Minato ,  Akihisa Ikeno ,  Kunihiko Takeyama ,  Kanoo Hosoki

    IPC分类号： A61K31/495 ,  C07D337/12

    CPC分类号： A61K31/495 ,  C07D337/12

    摘要： The present invention is to provide an ameliorant for blood lipid metabolism which comprises as an active ingredient N-(6,11-dihydrodibenzo[b,e]thiepin-11-yl)-4-(4-fluorophenyl)-1-piperazinebutanamide or a pharmaceutically acceptable salt thereof, more particularly, to provide a hyperlipidemia inhibitor and an atherosclerosis inhibitor.

    摘要翻译： PCT No.PCT / JP92 / 01173 Sec。 371日期：1994年3月14日 102（e）1994年3月14日PCT提交1992年9月14日PCT公布。 公开号WO93 / 05778 日期：1993年04月1日本发明提供一种血脂代谢改善剂，其包含作为活性成分的N-（6,11-二氢二苯并[b，e]硫杂-11-基）-4-（4- 氟苯基）-1-哌嗪丁酰胺或其药学上可接受的盐，更具体地，提供高脂血症抑制剂和动脉粥样硬化抑制剂。

    Tripeptide derivatives
    2.
    发明授权
    Tripeptide derivatives 失效

    公开(公告)号：US4826814A

    公开(公告)日：1989-05-02

    申请号：US046189

    申请日：1987-05-05

    申请人： Tadahiro Sawayama ,  Masatoshi Tsukamoto ,  Takashi Sasagawa ,  Kazuya Nishimura ,  Kanoo Hosoki ,  Kunihiko Takeyama

    发明人： Tadahiro Sawayama ,  Masatoshi Tsukamoto ,  Takashi Sasagawa ,  Kazuya Nishimura ,  Kanoo Hosoki ,  Kunihiko Takeyama

    IPC分类号： A61K38/00 ,  A61K38/05 ,  A61K38/06 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/068 ,  C07K5/08 ,  C07K14/81 ,  A61K37/43

    CPC分类号： C07K5/06086 ,  C07K5/0215 ,  A61K38/00

    摘要： There are provided tripeptide compounds represented by the following formula ##STR1## wherein R.sub.1 represents a C.sub.1-10 alkyl group, a C.sub.4-7 cycloalkyl or C.sub.5-7 cycloalkyl-lower alkyl group, a phenyl or phenyl-lower alkyl group in which the benzene ring may optionally be substituted by a substituent selected from halogen, lower alkyl, lower alkoxy, phenyl, methylenedioxy, ethylenedioxy, amino, di(lower alkyl)amino and hydroxy, a naphthyl or naphthyl-lower alkyl group in which the naphthalene ring may optionally be substituted by a substituent selected from halogen, lower alkyl, lower alkoxy and hydroxy, a heterocyclic or heterocyclic-lower alkyl group in which the heterocycle is a saturated or unsaturated 5- or 6-membered ring containing a nitrogen, oxygen or sulfur atom as the hetero atom, and may optionally be substituted by a substituent selected from halogen, lower alkyl, lower alkoxy, amino, di(lower alkyl)amino, hydroxy, oxo and saturated 5- or 6-membered nitrogen-containing heterocyclic group, and further may optionally be fused to a benzene ring, or an imidazolylvinyl group; R.sub.2 represents a hydrogen atom, a C.sub.1-10 alkyl group or a benzyl group; R.sub.3 represents a group of the formula ##STR2## represents a benzene, cyclopentane or cyclohexane ring, R.sub.4 represents a hydrogen atom, a C.sub.1-10 alkyl group or a benzyl group, p is 0 or 1, q is 1, 2, or 3, and X represents a phenyl group which may optionally be substituted by a substituent selected from halogen, lower alkoxy and hydroxy, a C.sub.4-8 cycloalkyl group, or a C.sub.5-7 cycloalkyl group which is fused to a benzene, and Y represents a hydrogen atom or a lower alkyl group, or X and Y, together with the nitrogen and carbon atoms to which they are bonded, forms a 5- or 6-membered heterocycle which may contain a nitrogen, oxygen or sulfur atom,W represents a single bond, --O-- or --NH--, T represents a single bond, ##STR3## and m is 2 or 3, or salts thereof and processes for production thereof. The compounds are useful as antihypertensive agents.