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1.发明授权
公开(公告)号：US4327101A
公开(公告)日：1982-04-27
申请号：US188713
申请日：1980-09-19
IPC分类号： A61K31/47 , A61P31/04 , C07C205/12 , C07D215/56
CPC分类号： C07D215/56 , C07C205/12
摘要： A quinoline compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or fluorine. A method of preparing the compound (I) is disclosed. The compound (I) and a pharmaceutically acceptable salt thereof are useful as antimicrobial agents.
摘要翻译： 下式的喹啉化合物：其中R 1是氢或氟。 公开了制备化合物（I）的方法。 化合物（I）及其药学上可接受的盐可用作抗微生物剂。
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公开(公告)号：US4727071A
公开(公告)日：1988-02-23
申请号：US835886
申请日：1986-03-04
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , A61P31/04 , C07D417/12 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D499/44
CPC分类号： C07D501/24 , C07D417/12 , Y02P20/55
摘要： A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl;R.sup.2 is acetoxy or (1-methyl-1H-tetrazol-5-yl)thio, andR.sup.3 is carboxy; orR.sup.2 is a group of the formula: ##STR2## R.sup.3 is --COO.sup.- and Y is hydrogen, hydroxymethyl or carbamoyl; andn is an integer of 2 or 3,or a pharmaceutically acceptable salt thereof and processes for their preparation are disclosed. Said cephalosporin compound is useful as an antimicrobial agent.
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公开(公告)号：US4053609A
公开(公告)日：1977-10-11
申请号：US711858
申请日：1976-08-05
申请人： Mitsutaka Kawazu , Mitsuyoshi Wagatsuma , Masahiko Seto , Toshikazu Miyagishima , Totaro Yamaguchi , Satoshi Ohshima
发明人： Mitsutaka Kawazu , Mitsuyoshi Wagatsuma , Masahiko Seto , Toshikazu Miyagishima , Totaro Yamaguchi , Satoshi Ohshima
IPC分类号： C07C271/22 , C07D207/46 , C07D499/00 , C07D499/68 , A61K31/43
CPC分类号： C07C271/22 , C07D207/46 , C07D499/00
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is a group of the formula: --CO-CH(NH.sub.2)-CH.sub.2 COR.sup.3 or --COCH.sub.2 -CH(NH.sub.2)-COR.sup.3, and R.sup.3 is selected from the group consisting of hydroxy, lower alkylamino, di-lower alkylamino, lower alkoxy and hydroxy-lower alkylamino, or R.sup.3 is amino when R.sup.2 is hydroxy. Several methods of preparing the compound [I] are also disclosed. The compound [I] and a pharmaceutically acceptable salt thereof are useful as antimicrobial agents.
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公开(公告)号：US4598154A
公开(公告)日：1986-07-01
申请号：US692497
申请日：1985-01-18
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , A61P31/04 , C07D417/12 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D277/42
CPC分类号： C07D501/24 , C07D417/12 , Y02P20/55
摘要： A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl;R.sup.2 is acetoxy or (1-methyl-1H-tetrazol-5-yl)thio, andR.sup.3 is carboxy; orR.sup.2 is a group of the formula ##STR2## R.sup.3 is --COO.sup.- and Y is hydrogen, hydroxymethyl or carbamoyl; andn is an integer of 2 or 3,or a pharmaceutically acceptable salt thereof and processes for their preparation are disclosed. Said cephalosporin compound is useful as an antimicrobial agent.
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公开(公告)号：US4576938A
公开(公告)日：1986-03-18
申请号：US447809
申请日：1982-12-08
IPC分类号： C07D257/04 , C07D417/12 , C07D417/14 , C07D501/36 , A61K31/545 , C07D501/56
CPC分类号： C07D257/04 , C07D417/12 , C07D417/14
摘要： A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a carboxy(lower)alkyl group, a hydroxy(lower)alkyl group, a carbamoyl(lower)alkyl group, an N-(lower)alkyl-carbamoyl(lower)alkyl group, a cycloalkyl group, a carboxycycloalkyl group, or a tetrazolylmethyl group, R.sup.2 is a hydrogen atom, a lower alkyl group, a formyl group or a lower alkanol group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 are combined together to form an aralkylidene group, or a pharmaceutically acceptable salt thereof which is useful as an antimicrobial agent, and process for their preparation.
摘要翻译： 下式的头孢菌素化合物：其中R1是氢原子，低级烷基，羧基（低级）烷基，羟基（低级）烷基，氨基甲酰基（低级）烷基，N-（ 低级）烷基 - 氨基甲酰基（低级）烷基，环烷基，羧基环烷基或四唑基甲基，R2是氢原子，低级烷基，甲酰基或低级链烷醇基，R3是氢原子， 或R2和R3组合在一起形成可用作抗微生物剂的芳烷基或其药学上可接受的盐及其制备方法。
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公开(公告)号：US4598075A
公开(公告)日：1986-07-01
申请号：US516053
申请日：1983-07-21
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , A61P31/04 , C07D417/12 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D499/44
CPC分类号： C07D501/24 , C07D417/12 , Y02P20/55
摘要： A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl;R.sup.2 is acetoxy or (1-methyl-1H-tetrazol-5-yl)thio, andR.sup.3 is carboxy; orR.sup.2 is a group of the formula: ##STR2## R.sup.3 is --COO.sup.- and Y is hydrogen, hydroxymethyl or carbamoyl; andn is an integer of 2 or 3,or a pharmaceutically acceptable salt thereof and processes for their preparation are disclosed. Said cephalosporin compound is useful as an antimicrobial agent.
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公开(公告)号：US4547494A
公开(公告)日：1985-10-15
申请号：US578380
申请日：1984-02-09
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D257/04 , C07D417/12 , C07D501/36 , C07D501/60
CPC分类号： C07D257/04 , C07D417/12 , Y02P20/55
摘要： A 7.beta.-{(Z)-2-(2-aminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetamido}-3-(1-amino-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid or a pharmaceutically acceptable salt thereof is useful as an antimicrobial agent.
摘要翻译： 将7β-{（Z）-2-（2-氨基噻唑-4-基）-2 - [（2-吡咯烷酮-3-基）氧亚氨基]乙酰氨基} -3-（1-氨基-1H-四唑-5 - 基）硫代甲基-3-头孢烯-4-羧酸或其药学上可接受的盐可用作抗微生物剂。
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公开(公告)号：US4742174A
公开(公告)日：1988-05-03
申请号：US920180
申请日：1986-10-17
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , A61P31/04 , C07D417/12 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46
CPC分类号： C07D501/24 , C07D417/12 , Y02P20/55
摘要： A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl;R.sup.2 is acetoxy or (1-methyl-1H-tetrazol-5-yl)thio, andR.sup.3 is carboxy; orR.sup.2 is a group of the formula: ##STR2## R.sup.3 is --COO.sup.- and Y is hydrogen, hydroxymethyl or carbamoyl; andn is an integer of 2 or 3,or a pharmaceutically acceptable salt thereof and processes for their preparation are disclosed. Said cephalosporin compound is useful as an antimicrobial agent.
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公开(公告)号：US5208348A
公开(公告)日：1993-05-04
申请号：US913506
申请日：1992-07-14
IPC分类号： C07D477/20
CPC分类号： C07D477/20
摘要： A mercaptan compound of the formula ##STR1## wherein R.sup.3 is a hydrogen atom or a lower alkyl group, or a salt thereof.
摘要翻译： 其中R3是氢原子或低级烷基的式“IMAGE”的硫醇化合物或其盐。
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公开(公告)号：US5153187A
公开(公告)日：1992-10-06
申请号：US755884
申请日：1991-09-06
IPC分类号： A61K31/40 , A61K31/397 , A61P31/04 , C07D207/24 , C07D477/00 , C07D477/20
CPC分类号： C07D477/20 , Y02P20/55
摘要： 1-Methylcarbapenem derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a hydroxy-protecting group, R.sup.2 is hydrogen atom or an ester residue, R.sup.3 is hydrogen atom or a lower alkyl group, or salts thereof, which have excellent antimicrobial activities and are useful as an antimicrobial drug.
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