公开(公告)号：US07667005B2

公开(公告)日：2010-02-23

申请号：US12046718

申请日：2008-03-12

申请人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

发明人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

IPC分类号： C07K16/28

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  A01K2267/0393 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N2799/026 ,  C12N2800/30

摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.

摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。

公开(公告)号：US20080227158A1

公开(公告)日：2008-09-18

申请号：US12046718

申请日：2008-03-12

申请人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

发明人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

IPC分类号： C12P21/04 ,  C07K16/18 ,  C12N5/06

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  A01K2267/0393 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N2799/026 ,  C12N2800/30

摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.

摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。

公开(公告)号：US06579850B1

公开(公告)日：2003-06-17

申请号：US09344510

申请日：1999-06-25

申请人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

发明人： Youichi Nabeshima ,  Makoto Kuroo ,  Susumu Sekine ,  Akihiro Iida

IPC分类号： A61K3816

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  A01K2267/0393 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N2799/026 ,  C12N2800/30

摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome. resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.

摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。

公开(公告)号：US5747652A

公开(公告)日：1998-05-05

申请号：US360127

申请日：1994-12-20

申请人： Ryozo Nagai ,  Makoto Kuroo ,  Hirohisa Kato

发明人： Ryozo Nagai ,  Makoto Kuroo ,  Hirohisa Kato

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/68

CPC分类号： C07K16/18 ,  C07K14/4716 ,  G01N33/6887

摘要： Using as an immunogen an oligopeptide containing a different portion of the amino acid sequence of isoform SM-1, SM-2 or SM-3 in smooth muscle myosin heavy chains, for example, the C-terminus amino acid sequence, antibodies capable of distinctly recognizing each isoform from other isoforms of the smooth muscle myosin heavy chains can be obtained. The antibodies are useful as reagents for tissue staining and also useful as diagnostic reagents of vascular disturbance or arteriosclerosis.

摘要翻译： 作为免疫原使用含有平滑肌肌球蛋白重链中同种型SM-1，SM-2或SM-3的氨基酸序列的不同部分的寡肽，例如C末端氨基酸序列，能明确地 从平滑肌肌球蛋白重链的其他异构体识别各种同种型。 抗体可用作组织染色的试剂，也可用作血管紊乱或动脉硬化的诊断试剂。