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公开(公告)号：US07667005B2
公开(公告)日：2010-02-23
申请号：US12046718
申请日：2008-03-12
申请人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
发明人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
IPC分类号： C07K16/28
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0393 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , C12N2799/026 , C12N2800/30
摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.
摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。
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公开(公告)号：US20080227158A1
公开(公告)日：2008-09-18
申请号：US12046718
申请日：2008-03-12
申请人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
发明人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0393 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , C12N2799/026 , C12N2800/30
摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.
摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。
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公开(公告)号：US06579850B1
公开(公告)日：2003-06-17
申请号：US09344510
申请日：1999-06-25
申请人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
发明人： Youichi Nabeshima , Makoto Kuroo , Susumu Sekine , Akihiro Iida
IPC分类号： A61K3816
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0393 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , C12N2799/026 , C12N2800/30
摘要： The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome. resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.
摘要翻译： 本发明涉及具有抑制老化活性的多肽; 编码多肽的DNA; 使用DNA改善家畜的方法; 通过将DNA插入载体制备的重组DNA; 携带重组体的转化体; 使用该转化体制备本发明多肽的方法; 识别多肽的抗体; 本发明多肽的配体; 抑制本发明的多肽和配体之间的特异性结合的化合物; 提高编码本发明的老化抑制多肽的老化抑制基因的表达的化合物; 在DNA的核苷酸序列中含有10〜50个核苷酸序列的寡核苷酸; 以及类似于过早衰老的综合症的治疗剂，成人疾病的治疗剂或老化抑制剂。
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公开(公告)号：US5494790A
公开(公告)日：1996-02-27
申请号：US309985
申请日：1994-09-20
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译： 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。
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公开(公告)号：US4689402A
公开(公告)日：1987-08-25
申请号：US750587
申请日：1985-07-01
申请人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
发明人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
摘要： According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.
摘要翻译： 根据本发明，获得了与编码鱼生长激素多肽的DNA和含有重组DNA的微生物结合的重组DNA，可以用于大量生产鱼类生长激素多肽。
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6.发明授权Methods for synthesizing sugar chains using β1,3-N-acetylglucosaminyltransferase 有权使用1,3-N-乙酰葡糖胺基转移酶合成糖链的方法公开(公告)号：US08722366B2
公开(公告)日：2014-05-13
申请号：US13164814
申请日：2011-06-21
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有“1,3-N-乙酰葡糖胺基转移酶”活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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公开(公告)号：US20120156732A1
公开(公告)日：2012-06-21
申请号：US13164814
申请日：2011-06-21
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
IPC分类号： C12P19/18
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有“1,3-N-乙酰葡糖胺基转移酶”活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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公开(公告)号：US5384249A
公开(公告)日：1995-01-24
申请号：US991587
申请日：1992-12-16
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译： 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。
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公开(公告)号：US5052124A
公开(公告)日：1991-10-01
申请号：US426891
申请日：1989-10-23
申请人： Susumu Sekine , Katsumi Ito , Noriyoshi Ohwada , Toyoaki Eguchi
发明人： Susumu Sekine , Katsumi Ito , Noriyoshi Ohwada , Toyoaki Eguchi
CPC分类号： B21C47/262 , C21D9/5732
摘要： A method for transporting a hot-rolled wire rod comprises changing directions of movements of the wire rod to the left and to the right relative to the center line of a conveyer at an interval of d/3 to 2d of a diameter of a ring of the wire rod and shifting the center of the ring of the wire rod from the center line of the conveyer by a length of 2d/100 to 30d/100 at its maximum.An apparatus for transporting hot-rolled wire rod comprises a conveyer for transporting a hot-rolled wire rod and guide means alternately arranged in an upper portion of the side of the conveyer to change the directions of movements of the wire rod to the left and to the right relative to the center line of the conveyer.A further apparatus for transporting hot-rolled wire rod comprises side walls arranged in zigzags facing each other on the both sides of the conveyer to have the wire rod move in zigzags with the center line of the conveyer as the center and guide members arranged on the side walls arranged toward the center line of the conveyer.
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公开(公告)号：US4795805A
公开(公告)日：1989-01-03
申请号：US104578
申请日：1987-10-02
IPC分类号： C12N15/09 , C07H21/04 , C07K14/15 , C07K14/435 , C07K19/00 , C12N1/00 , C12P21/00 , C12R1/19 , C07K13/00
CPC分类号： C07K14/005 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2740/14022 , Y10S530/806 , Y10S530/808 , Y10S530/82 , Y10S530/825
摘要： Recombinant plasmids are constructed by inserting a DNA fragment coding for a fused protein of an adult T cell leukemia virus antigen peptide and an enzyme into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the fused protein. The fused protein is useful for the detection and diagnosis of adult T cell leukemia.
摘要翻译： 通过将编码成人T细胞白血病病毒抗原肽和酶的融合蛋白的DNA片段插入载体DNA构建重组质粒。 用重组质粒转化微生物，然后培养以表达融合蛋白。 融合蛋白可用于检测和诊断成人T细胞白血病。
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