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1.发明申请Pharmaceutical composition comprising an immunoglobulin fc region as a carrier 有权药物组合物，其包含免疫球蛋白fc区域作为载体公开(公告)号：US20060275254A1
公开(公告)日：2006-12-07
申请号：US10535231
申请日：2004-11-13
IPC分类号： A61K39/395 , C07K16/46 , A61K38/19 , A61K38/21
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed is a novel use of an immunoglobulin Fe fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fe fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fe fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fe fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
摘要翻译： 公开了免疫球蛋白Fe片段的新用途，更具体地，涉及包含免疫球蛋白Fe片段作为载体的药物组合物。 包含作为载体的免疫球蛋白Fe片段的药物组合物显着延长了药物的血清半衰期，同时保持药物的体内活性在相对较高的水平。 此外，当药物是多肽药物时，与免疫球蛋白Fe片段和靶蛋白质的融合蛋白相比，药物组合物具有较少的诱导免疫应答的风险，因此可用于开发各种多肽药物的长效制剂。
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2.发明申请公开(公告)号：US20080085862A1
公开(公告)日：2008-04-10
申请号：US11744162
申请日：2007-05-03
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： The present invention relates to an Natriuretic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an Natriuretic peptide, a non-peptidyl polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The Natriuretic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long-acting formulations of various peptide drugs.
摘要翻译： 本发明涉及具有改善的功效和稳定性的体内持续时间的利尿钠肽缀合物，其包含彼此共价连接的利尿钠肽，非肽基聚合物和载体物质及其用途。 本发明的利钠肽结合物具有保持较高的体内活性，并且具有显着增加的血液半衰期，因此可以理想地用于开发各种肽药物的长效制剂。
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3.发明申请Peg-physiologically active polypeptide homodimer complex having prolonged in vivo half-life and process for the preparation thereof 审中-公开具有延长的体内半衰期的Peg生理活性多肽同二聚体复合物及其制备方法公开(公告)号：US20060276586A1
公开(公告)日：2006-12-07
申请号：US10551764
申请日：2004-04-03
CPC分类号： C07K14/475 , A61K47/60 , C07K14/53 , C07K14/56 , C07K14/575 , C07K14/61 , C07K2319/00
摘要： A PEG-polypeptide homodimer complex, which comprises a PEG linker and two molecules of a physiologically active polypeptide, wherein the two molecules of the physiologically active polypeptide are connected via the PEG linker, and each of the two molecules of the physiologically active polypeptide is modified with one molecule of PEG, is useful for the development of a polypeptide drug having a prolonged half-life in the blood.
摘要翻译： PEG-多肽同二聚体复合物，其包含PEG接头和两个生理活性多肽分子，其中生理活性多肽的两个分子通过PEG接头连接，并且生理活性多肽的两个分子中的每一个被修饰 使用一分子PEG可用于开发血液中具有延长半衰期的多肽药物。
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4.发明申请Protein complex using an immunoglobulin fragment and method for the preparation thereof 有权使用免疫球蛋白片段的蛋白质复合物及其制备方法公开(公告)号：US20060269553A1
公开(公告)日：2006-11-30
申请号：US10535232
申请日：2004-11-13
IPC分类号： A61K39/395 , C07K16/46 , C12N9/00
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
摘要翻译： 公开了具有改善的体内持续时间和稳定性的蛋白质缀合物及其用途。 蛋白质缀合物包括生理活性多肽，非肽聚合物和免疫球蛋白Fc片段。 由于三种成分共价连接，因此蛋白质缀合物延长了生理活性多肽的体内持续时间和增强的稳定性。 蛋白质缀合物以较高的水平保持体内活性，并显着增加生理活性多肽的血清半衰期，具有诱导不良免疫反应的风险较小。 因此，蛋白质缀合物可用于开发各种多肽药物的长效制剂。
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5.发明申请Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same 有权结晶S-奥美拉唑锶水合物，其制备方法和含有它们的药物组合物公开(公告)号：US20070093533A1
公开(公告)日：2007-04-26
申请号：US11374034
申请日：2006-03-14
IPC分类号： A61K31/4439 , C07D403/02 , C07F3/02
CPC分类号： C07D401/12
摘要： This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 本发明提供了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑水合锶，其具有高光学纯度，耐受性，溶解性和不吸湿性，其制备方法和含有该组合物的药物组合物。
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公开(公告)号：US20050128443A1
公开(公告)日：2005-06-16
申请号：US11007331
申请日：2004-12-09
CPC分类号： H04N9/3188 , H04N9/3141
摘要： A system for displaying an image with a more improved resolution than the actual physical resolution, thereby obtaining the same effect of a resolution which is physically improved, wherein an image signal corresponding to one frame is separated into a first image signal and a second image signal, and a first image and a second image are formed based on the first image signal and the second image signal. The first image and the second image are respectively displayed at a first location and a second location, whereby a viewer can view the image at an improved resolution.
摘要翻译： 一种用于显示具有比实际物理分辨率更高的分辨率的图像的系统，从而获得物理上改善的分辨率的相同效果，其中对应于一帧的图像信号被分为第一图像信号和第二图像信号 并且基于第一图像信号和第二图像信号形成第一图像和第二图像。 第一图像和第二图像分别显示在第一位置和第二位置，由此观看者可以以改进的分辨率观看图像。
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公开(公告)号：US20050128438A1
公开(公告)日：2005-06-16
申请号：US11007260
申请日：2004-12-09
CPC分类号： H04N9/3188 , H04N9/3141
摘要： A system for displaying an image with a more improved resolution than the actual physical resolution, thereby obtaining the same effect of a resolution which is physically improved, wherein an image signal corresponding to one frame is separated into a first image signal and a second image signal, and a first image and a second image are formed based on the first image signal and the second image signal. The first image and the second image are respectively displayed at a first location and a second location, whereby a viewer can view the image at an improved resolution.
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公开(公告)号：US20050275810A1
公开(公告)日：2005-12-15
申请号：US11024670
申请日：2004-12-30
CPC分类号： H04N5/74 , G02B26/0875 , G03B21/005
摘要： A concept of improving a resolution by using human's visual characteristics is provided. An image can be displayed at a more improved resolution than an actual physical resolution, thereby obtaining the same effect that the resolution is physically improved. An image signal corresponding to one frame is split into a first image signal and a second image signal, and a first image and a second image are formed based on the first image signal and the second image signal. Then, the first image and the second image are respectively displayed at a first location and a second location. As a result, a viewer can view the image at an improved resolution.
摘要翻译： 提供了通过使用人的视觉特征来提高分辨率的概念。 可以以比实际物理分辨率更高的分辨率显示图像，从而获得与物理上改善的分辨率相同的效果。 对应于一帧的图像信号被分割为第一图像信号和第二图像信号，并且基于第一图像信号和第二图像信号形成第一图像和第二图像。 然后，分别在第一位置和第二位置显示第一图像和第二图像。 结果，观看者可以以改进的分辨率观看图像。
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公开(公告)号：US20070076721A1
公开(公告)日：2007-04-05
申请号：US11541564
申请日：2006-10-03
申请人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
发明人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
IPC分类号： H04L12/56
CPC分类号： H04N21/435 , H04H20/30 , H04H20/55 , H04H20/72 , H04H40/27 , H04N21/235 , H04N21/23614 , H04N21/2362 , H04N21/2383 , H04N21/41422 , H04N21/4345 , H04N21/4348 , H04N21/4382 , H04N21/64315 , H04N21/8126
摘要： A digital broadcast transmitting/receiving system and a method for processing data are disclosed. The method for processing data may enhance the receiving performance of the receiving system by performing additional coding and multiplexing processes on the traffic information data and transmitting the processed data. Thus, robustness is provided to the traffic information data, thereby enabling the data to respond strongly against the channel environment which is always under constant and vast change.
摘要翻译： 公开了数字广播发送/接收系统和数据处理方法。 处理数据的方法可以通过对交通信息数据执行额外的编码和复用处理并发送处理的数据来增强接收系统的接收性能。 因此，提供了对交通信息数据的鲁棒性，从而使得数据能够对始终处于不断变化和巨大变化的信道环境产生强烈反应。
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公开(公告)号：US20070076585A1
公开(公告)日：2007-04-05
申请号：US11542160
申请日：2006-10-04
申请人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
发明人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
IPC分类号： H04J11/00
CPC分类号： H04H20/44 , H04B1/0475 , H04B1/10 , H04H20/55 , H04L1/0065 , H04L1/0071 , H04L1/0083 , H04L2001/0093
摘要： A digital broadcast transmitting/receiving system and a method for processing data are disclosed. The method for processing data may enhance the receiving performance of the receiving system by performing additional coding and multiplexing processes on the traffic information data and transmitting the processed data. Thus, robustness is provided to the traffic information data, thereby enabling the data to respond strongly against the channel environment which is always under constant and vast change.
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