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    ANTI-C-MET ANTIBODY HAVING HGF ACTIVITY AND USE THEREOF
    1.
    发明申请
    ANTI-C-MET ANTIBODY HAVING HGF ACTIVITY AND USE THEREOF 有权
    具有HGF活性的抗C-MET抗体及其用途

    公开(公告)号：US20140193431A1

    公开(公告)日：2014-07-10

    申请号：US14123533

    申请日：2012-06-04

    申请人： Young Woo Park ,  KiWon Jo ,  Chan Woong Park ,  Seok Ho Yoo ,  Myeoung Hee Jang ,  Hye Nan Kim ,  Seon Ha Yun ,  Kyu Won Cho ,  Mi Ra Park

    发明人： Young Woo Park ,  KiWon Jo ,  Chan Woong Park ,  Seok Ho Yoo ,  Myeoung Hee Jang ,  Hye Nan Kim ,  Seon Ha Yun ,  Kyu Won Cho ,  Mi Ra Park

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

    摘要： Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.

    摘要翻译： 公开了包含与c-Met特异性结合的人互补决定区（CDR）的人抗体和框架区（FR），编码人抗体的多核苷酸，包含多核苷酸的表达载体，转化了 表达载体，通过培养转化体生产人抗体B7的方法，包含人抗体作为活性成分的伤口愈合组合物，包含抗体作为活性成分的细胞再生组合物和包含药物连接的药物偶联物 对人抗体。 c-Met特异性人抗体可用作可用作伤口愈合组合物的HGF模拟物。 该抗体可广泛用于确定通过激活HGF或其他疾病治疗的各种疾病的治疗和预后，包括神经元梗死，进行性肾病，肝硬化，肺纤维化，肾损伤，肝损伤，肺损伤和溃疡性创伤 c-Met。