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1.发明申请METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS WITH HIGH EFFICIENCY AND INDUCED POLURIPOTENT STEM CELLS PROUCED THEREBY 有权用于生产具有高效率和诱导性的潜在干细胞的诱导型脑干细胞的方法公开(公告)号：US20110256626A1
公开(公告)日：2011-10-20
申请号：US13120331
申请日：2010-09-17
申请人： Young-Bae Park , Hyo-Soo Kim , Yoo-Wook Kwon , Hyun-Jai Cho , Jae-Seung Paek
发明人： Young-Bae Park , Hyo-Soo Kim , Yoo-Wook Kwon , Hyun-Jai Cho , Jae-Seung Paek
IPC分类号： C12N5/071
CPC分类号： C12N5/16 , C12N5/0696 , C12N2500/44 , C12N2500/84 , C12N2501/235 , C12N2506/00
摘要： The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.
摘要翻译： 本发明提供一种生产定制多能干细胞的方法。 具体地说，本发明包括以下步骤：从任何去分化干细胞或诱导多能干细胞中提取蛋白质，所述去分化或多能干细胞通过任何已知方法制备; 将蛋白质提取物引入成体体细胞; 并培养成体细胞以产生具有与胚胎干细胞相同多能性的多能干细胞。 此外，提供了根据本发明方法产生的多能干细胞和包含其的细胞治疗剂。 与典型的方法相比，该方法允许非常容易地和以显着更高的产量制造多能干细胞。
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2.发明授权公开(公告)号：US08673633B2
公开(公告)日：2014-03-18
申请号：US13120331
申请日：2010-09-17
申请人： Young-Bae Park , Hyo-Soo Kim , Yoo-Wook Kwon , Hyun-Jai Cho , Jae-Seung Paek
发明人： Young-Bae Park , Hyo-Soo Kim , Yoo-Wook Kwon , Hyun-Jai Cho , Jae-Seung Paek
CPC分类号： C12N5/16 , C12N5/0696 , C12N2500/44 , C12N2500/84 , C12N2501/235 , C12N2506/00
摘要： The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.
摘要翻译： 本发明提供一种生产定制多能干细胞的方法。 具体地说，本发明包括以下步骤：从任何去分化干细胞或诱导多能干细胞中提取蛋白质，所述去分化或多能干细胞通过任何已知方法制备; 将蛋白质提取物引入成体体细胞; 并培养成体细胞以产生具有与胚胎干细胞相同多能性的多能干细胞。 此外，提供了根据本发明方法产生的多能干细胞和包含其的细胞治疗剂。 与典型的方法相比，该方法允许非常容易地和以显着更高的产量制造多能干细胞。
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