-
公开(公告)号：US09174944B1
公开(公告)日：2015-11-03
申请号：US13328121
申请日：2011-12-16
IPC分类号： C07D239/10 , A61K31/513
CPC分类号： C07D213/64 , C07D239/10
摘要： This invention relates to novel crystalline lopinavir/surfactant adducts, methods for their preparation, therapeutic uses of those crystalline lopinavir/surfactant adducts, and pharmaceutical compositions containing them or made from them.
摘要翻译： 本发明涉及新的结晶洛匹那韦/表面活性剂加合物，其制备方法，那些结晶洛匹那韦/表面活性剂加合物的治疗用途，以及含有它们或由它们制备的药物组合物。
-
公开(公告)号：US08722657B2
公开(公告)日：2014-05-13
申请号：US13301257
申请日：2011-11-21
申请人： Nathaniel Catron , Shuang Chen , Yuchuan Gong , Geoff G. Zhang
发明人： Nathaniel Catron , Shuang Chen , Yuchuan Gong , Geoff G. Zhang
IPC分类号： A01N43/00 , A61K31/397 , A61K31/497
CPC分类号： C07D471/04
摘要： Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译： 盐酸盐和4-（4 - {[2-（4-氯苯基）-4,4-二甲基环己-1-烯-1-基]甲基}哌嗪-1-基）-N - （{3-硝基 -4 - [（四氢-2H-吡喃-4-基甲基）氨基]苯基} - 磺酰基）-2-（1H-吡咯并[2,3-b]吡啶-5-基氧基）苯甲酰胺是药物的合适的活性药物成分 可用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病的组合物。
-
公开(公告)号：US20120157470A1
公开(公告)日：2012-06-21
申请号：US13301257
申请日：2011-11-21
申请人： Nathaniel Catron , Shuang Chen , Yuchuan Gong , Geoff G. Zhang
发明人： Nathaniel Catron , Shuang Chen , Yuchuan Gong , Geoff G. Zhang
IPC分类号： A61K31/496 , A61P35/02 , A61P37/00 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译： 盐酸盐和4-（4 - {[2-（4-氯苯基）-4,4-二甲基环己-1-烯-1-基]甲基}哌嗪-1-基）-N - （{3-硝基 -4 - [（四氢-2H-吡喃-4-基甲基）氨基]苯基} - 磺酰基）-2-（1H-吡咯并[2,3-b]吡啶-5-基氧基）苯甲酰胺是药物的合适的活性药物成分 可用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病的组合物。
-
公开(公告)号：US08598216B1
公开(公告)日：2013-12-03
申请号：US13328043
申请日：2011-12-16
申请人： Maurizio Acquasaliente , Didier Houllemare , Geoff Zhang , Pulla Singam , John Morris , Kennan Marsh , Martin Babcock , John Pavlina , Yi Shi , Yuchuan Gong
发明人： Maurizio Acquasaliente , Didier Houllemare , Geoff Zhang , Pulla Singam , John Morris , Kennan Marsh , Martin Babcock , John Pavlina , Yi Shi , Yuchuan Gong
IPC分类号： A61K31/426 , A61K31/41
CPC分类号： C07D277/18
摘要： The invention relates to ritonavir bis-hydrochloride, processes for the preparation of the ritonavir bis-hydrochloride, pharmaceutical compositions containing the ritonavir bis-hydrochloride and made from it, and methods of using the ritonavir bis-hydrochloride to inhibit HIV protease or enhance the pharmacokinetics of compounds which are metabolized by cytochrome P450 3A4.
摘要翻译： 本发明涉及利托那韦双盐酸盐，制备利托那韦双盐酸盐的方法，含有利托那韦双盐酸盐并由其制备的药物组合物，以及使用利托那韦双盐酸盐抑制HIV蛋白酶或增强药代动力学的方法 的化合物，其被细胞色素P450 3A4代谢。
-
![SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE](/abs-image/US/2012/08/23/US20120214841A1/abs.jpg.150x150.jpg)
5.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式公开(公告)号：US20120214841A1
公开(公告)日：2012-08-23
申请号：US13358778
申请日：2012-01-26
申请人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K31/47 , A61P11/00 , A61P7/00 , A61P3/10 , A61P5/00 , A61P35/00 , A61P19/08 , A61P25/28 , A61P25/16 , A61P25/00 , A61P21/00 , A61P3/00 , A61P27/02 , A61P37/06 , A61P7/12 , C07D215/56
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
-
![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2013/04/02/US08410274B2/abs.jpg.150x150.jpg)
公开(公告)号：US08410274B2
公开(公告)日：2013-04-02
申请号：US13358778
申请日：2012-01-26
申请人： Patricia Hurter , William Rowe , Christopher Ryan Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher Ryan Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： C07D215/38
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
-
![Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2011/03/17/US20110064811A1/abs.jpg.150x150.jpg)
7.发明申请Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 审中-公开固体形式的N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号：US20110064811A1
公开(公告)日：2011-03-17
申请号：US11647505
申请日：2006-12-28
申请人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K9/14 , C07D215/56 , A61K31/47 , A61P3/10 , A61P11/00 , A61P7/10 , A61P3/00 , A61P35/00 , A61P25/28 , A61P25/16 , A61P27/04 , A61P7/00
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.021 秒)
