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公开(公告)号:US20120077856A1
公开(公告)日:2012-03-29
申请号:US13309936
申请日:2011-12-02
申请人: Yuji IIZAWA , Masayuki Ii , Tomohiro Kawamoto
发明人: Yuji IIZAWA , Masayuki Ii , Tomohiro Kawamoto
IPC分类号: A61K31/215 , A61K31/41 , A61K31/4196 , A61K31/428 , A61P29/00 , A61P31/00 , A61P9/00 , A61P37/06 , A61P25/00 , A61P17/02 , A61P19/02 , A61P1/04 , A61P9/10 , A61P1/18 , A61P13/12 , A61P3/10 , A61P25/16 , A61P35/02 , A61P35/00 , A61P11/00 , A61P17/06 , A61K31/4192
CPC分类号: C07D249/06 , A61K31/216 , A61K31/41 , A61K31/4192 , A61K31/428 , A61K45/06 , C07D249/08 , C07D257/04 , C07D275/06 , A61K2300/00
摘要: An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.
摘要翻译: 用于抑制各种细胞因子(IL-8等)和炎性介质的产生的药剂,抑制COX-II等的表达的试剂或各种磷酸化酶(ATF2等)的抑制剂,其中 含有TLR信号传导抑制物质,优选式(I)或式(II)表示的化合物,其中各符号如说明书中所定义,或其盐或其前药。
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公开(公告)号:US20120232028A1
公开(公告)日:2012-09-13
申请号:US13476454
申请日:2012-05-21
申请人: Mitsuru SHIRAISHI , Masanori BABA , Katsuji AIKAWA , Naoyuki KANZAKI , Masaki SETO , Yuji IIZAWA
发明人: Mitsuru SHIRAISHI , Masanori BABA , Katsuji AIKAWA , Naoyuki KANZAKI , Masaki SETO , Yuji IIZAWA
IPC分类号: A61K31/395 , A61K31/341 , C07D405/12 , A61K31/4178 , C07D403/12 , C07D405/14 , C07D403/14 , A61K31/4196 , C07D225/06 , C07D313/20 , A61K31/7072 , A61K31/708 , A61K31/7068 , A61K31/513 , A61K31/551 , A61K31/496 , A61K31/52 , A61K31/536 , A61K31/427 , A61K31/4725 , C12N5/071 , A61K31/472 , A61P31/18 , A61P29/00 , A61P19/02 , A61P37/06 , A61P37/08 , A61P9/10 , A61P25/00 , A61P13/12 , A01N1/02 , C07D407/12
CPC分类号: A61K31/4196 , A61K31/395 , A61K31/4178 , C07D225/06 , C07D313/20 , C07D403/12 , C07D405/12 , C07D407/12
摘要: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atoms; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.
摘要翻译: 本发明提供具有CCR拮抗剂活性,特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明化合物由下式表示:其中,R 1为可被取代的5-至6-元环基; X1是债券等; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z1是二价环状环基等; Z2是键或类似物; R 2为氨基,可以被取代的含氮杂环基等,或其盐。
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