摘要:
An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.
摘要:
An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.
摘要:
In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers are stacked alternately, the plurality of metal layers include a plurality of low-filled metal layers having a lower filling rate of metal composing the metal layers than oppositely disposed metal layers adjacent to each other in a stacking direction. In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers are stacked alternately, the plurality of metal layers include a plurality of thin metal layers having a smaller thickness than oppositely disposed metal layers adjacent to each other in a stacking direction. In a multilayer piezoelectric element in which a plurality of piezoelectric layers and a plurality of metal layers composed mainly of an alloy are stacked alternately, the plurality of metal layers include a plurality of high-ratio metal layers having a higher ratio of a component constituting the alloy than oppositely disposed metal layers adjacent to each other in a stacking direction.
摘要:
A ceramic member in which the metal layers with high void ratio are sufficiently sintered to lower a residue of resin is produced.The method for manufacturing a ceramic member which comprises a step of forming a stacked compact from a plurality of metallic paste layers containing a metal component M1 that are stacked one on another via ceramic green sheets, and a step of firing the stacked compact, wherein at least one of plural metallic paste layers is formed as a second metallic paste layer that has the mass percentage X higher than that of the metallic paste layer that adjoin therewith in the stacking direction and a ceramic powder is contained in the second metallic paste layer in the step of forming the stacked compact, the mass percentage X being the proportion of the metal component M1 to the total metal content in the metallic paste layer.
摘要:
A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.
摘要:
A piezoelectric ceramic composition comprising a perovskite compound which contains, as metal components, Pb, Sr, Zr, Ti, Nb, Cr, Y, Co and at least one element selected from La, Gd, Nd, Sm and Pr, and may further contain Sb or Na, wherein when the composition formula is expressed as,(Pb.sub.1-x-.alpha.-y Sr.sub.x Na.sub..alpha. M.sub.y).sub.a [(Nb.sub.b Y.sub.c Cr.sub.d Co.sub.e Sb.sub..beta.).sub.f Ti.sub.g Zr.sub.1-f-g ]O.sub.3,wherein M is at least one element selected from La, Gd, Nd, Sm and Pr, then, x, y, a, b, c, d, e, f, g, .alpha. and .beta. satisfy the following relationships, 0.005.ltoreq.x.ltoreq.0.08, 0.002.ltoreq.y.ltoreq.0.05, 0.95.ltoreq.a.ltoreq.1.05, 0.47.ltoreq.b.ltoreq.0.70, 0.02.ltoreq.c.ltoreq.0.31, 0.11.ltoreq.d.ltoreq.0.42, 0.01.ltoreq.e.ltoreq.0.12, 0.02.ltoreq.f.ltoreq.0.15, 0.46.ltoreq.g.ltoreq.0.52, 0.ltoreq..alpha..ltoreq.0.005, 0.ltoreq..beta..ltoreq.0.13, and b+c+d+e+.beta.=1.00. The piezoelectric ceramic composition of the present invention exhibits a high electromechanical coupling coefficient Kp, a low mechanical quality factor Qm, a low dielectric constant .epsilon.r, excellent heat resistance, and can be preferably used as a piezoelectric part for being mounted on the surface and, particularly, as a digital piezoelectric.
摘要翻译:一种包含钙钛矿化合物的压电陶瓷组合物,其包含Pb,Sr,Zr,Ti,Nb,Cr,Y,Co和选自La,Gd,Nd,Sm和Pr中的至少一种元素作为金属成分,并且还可以进一步 含有Sb或Na,其中当组成式表示为(Pb1-x-α-ySrxNaαMy)a [(NbbYcCrdCoeBb)fTigZr1-fg] O3时,其中M为选自La,Gd, Nd,Sm和Pr,则x,y,a,b,c,d,e,f,g,α和β满足以下关系:0.005≤x≤0.08,0.002< /=0.05,0.95 = a = 1.05,0.47 = b = 0.70,0.02 = 0.31,0.11 = d <= 0.42,0.01 < /=0.12,0.02 = f = 0.15,0.46 = g = 0.52,0 <α= 0.005,0%β= 0.13,b + c + d + e + beta = 1.00。 本发明的压电陶瓷组合物表现出高机电耦合系数Kp,低机械品质因数Qm,低介电常数εr,耐热性优异,并且可优选用作安装在表面上的压电部件, ,特别是数字压电。
摘要:
The invention provides an exposure apparatus having a configuration such that, when a single laser light source having a plurality of light-emitting points is driven by a plurality of laser control apparatuses, mutual monitoring of the control state of the respective laser control apparatuses is possible, thus reducing malfunctions due to the effects of noise, and also provides a method to control this exposure apparatus, and an image forming apparatus. To accomplish this, the exposure apparatus does not execute light amount control of the light source to be driven when the determination unit has determined that another driving unit is causing the light source to be driven to emit light, and executes the light amount control of the light source to be driven when the determination unit has determined that another driving unit is not causing the light source to be driven to emit light.
摘要:
The invention provides an exposure apparatus having a configuration such that, when a single laser light source having a plurality of light-emitting points is driven by a plurality of laser control apparatuses, mutual monitoring of the control state of the respective laser control apparatuses is possible, thus reducing malfunctions due to the effects of noise, and also provides a method to control this exposure apparatus, and an image forming apparatus. To accomplish this, the exposure apparatus does not execute light amount control of the light source to be driven when the determination unit has determined that another driving unit is causing the light source to be driven to emit light, and executes the light amount control of the light source to be driven when the determination unit has determined that another driving unit is not causing the light source to be driven to emit light.
摘要:
The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.
摘要:
An optical power control apparatus includes a changing unit which changes, a plurality of number of times, the value of a current flowing to an optical beam output apparatus, and an obtaining unit which obtains, in correspondence with each current value, a peripheral optical power representing an optical power at the peripheral part of the spot of the optical beam output from the optical beam output apparatus. The optical power control apparatus also includes a correction unit which corrects the peripheral optical power so that the peripheral optical power and a central optical power representing an optical power at the central part of the spot have an approximately linear relationship in correspondence with each current value. The optical power control apparatus also includes a control unit which controls the optical power of the optical beam output from the optical beam output apparatus in accordance with the corrected peripheral optical power.