公开(公告)号：US07415144B2

公开(公告)日：2008-08-19

申请号：US11390419

申请日：2006-03-28

申请人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

发明人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

IPC分类号： G06K9/00

CPC分类号： G01N21/253 ,  C12Q1/04

摘要： The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a stimulating unit applying a predetermined stimulation to the plural cells; a determining unit determining initial states of the plural cells from the image which is acquired by the image acquisition unit before the stimulating unit applies the stimulation; a finding unit finding reactions of the plural cells to the stimulation, from the image acquired by the image acquisition unit after the stimulating unit applies the stimulation; and a generating unit generating information on correlation between the initial states and the reactions of the plural cells.

摘要翻译： 细胞观察装置和方法旨在容易地研究细胞初始状态与其反应之间的相关性，而不使用同步培养方法。 为此，细胞观察装置包括获取包含多个细胞的标本的图像的图像获取单元; 刺激单元，对所述多个细胞施加预定的刺激; 确定单元，在所述刺激单元施加所述刺激之前，从所述图像获取单元获取的图像中确定所述多个单元的初始状态; 发现单元从刺激单元施加刺激之后由图像获取单元获取的图像中发现多个单元对刺激的反应; 以及生成单元，生成关于初始状态与多个单元的反应之间的相关性的信息。

公开(公告)号：US20060210962A1

公开(公告)日：2006-09-21

申请号：US11390419

申请日：2006-03-28

申请人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

发明人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

IPC分类号： C12Q1/00 ,  C12M1/34

CPC分类号： G01N21/253 ,  C12Q1/04

摘要： The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a stimulating unit applying a predetermined stimulation to the plural cells; a determining unit determining initial states of the plural cells from the image which is acquired by the image acquisition unit before the stimulating unit applies the stimulation; a finding unit finding reactions of the plural cells to the stimulation, from the image acquired by the image acquisition unit after the stimulating unit applies the stimulation; and a generating unit generating information on correlation between the initial states and the reactions of the plural cells.

摘要翻译： 细胞观察装置和方法旨在容易地研究细胞初始状态与其反应之间的相关性，而不使用同步培养方法。 为此，细胞观察装置包括获取包含多个细胞的标本的图像的图像获取单元; 刺激单元，对所述多个细胞施加预定的刺激; 确定单元，在所述刺激单元施加所述刺激之前，从所述图像获取单元获取的图像中确定所述多个单元的初始状态; 发现单元从刺激单元施加刺激之后由图像获取单元获取的图像中发现多个单元对刺激的反应; 以及生成单元，生成关于初始状态与多个单元的反应之间的相关性的信息。

公开(公告)号：US08208202B2

公开(公告)日：2012-06-26

申请号：US12500202

申请日：2009-07-09

申请人： Ichiro Sase

发明人： Ichiro Sase

IPC分类号： G02B21/00

CPC分类号： G02B21/245 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/32

摘要： A focus detection apparatus is provided with a light source 16 that emanates light with a given wavelength range; a reflection member 15 that reflects light emanated from the light source 16 to lead to an object 6a, reflects light from the light source 16 reflected from the object 6a, and transmits light from the object 6a with at least two different wavelength ranges except the light reflected from the object 6a; a photodetector 21 detecting the light from the light source 16 reflected from the object 6a; and a controller 22 detecting a focus shift between the objective lens 8 and the object 6a in the microscope 2 based on a signal detected by the photodetector 21, thereby providing a focus detection apparatus capable of limiting wavelength range of light for focus detection thereby able to use wider wavelength range for the microscope observation, and a microscope equipped therewith.

摘要翻译： 焦点检测装置设置有发出具有给定波长范围的光的光源16; 反射从光源16发出的光以反射物体6a的反射构件15反射来自物体6a反射的光源16的光，并且透过除了光之外的至少两个不同波长范围的光 从物体6a反射; 检测从物体6a反射的光源16的光的光检测器21; 以及控制器22，基于由光检测器21检测出的信号，在显微镜2中检测物镜8与物体6a之间的聚焦偏移，由此提供一种能够限制用于焦点检测的光的波长范围的焦点检测装置，从而能够 使用更宽的波长范围进行显微镜观察，并配备显微镜。

公开(公告)号：US20050248837A1

公开(公告)日：2005-11-10

申请号：US11121961

申请日：2005-05-05

申请人： Ichiro Sase ,  Katsuya Watanabe

发明人： Ichiro Sase ,  Katsuya Watanabe

IPC分类号： G02B21/00 ,  G02B21/36

CPC分类号： G02B21/32 ,  G02B21/002

摘要： The purpose is to move an observation field of view of a microscope without moving or changing an objective lens without varying position or state of a sample. A microscope optical system according to the present invention has a mirror that changes the direction of the optical path by reflection and locates in the optical path between an objective lens of the microscope and an image to be observed. The mirror is able to be tilted with changing the position of a reflecting surface of the mirror. Accordingly, the observation field of view is moved by tilting the mirror. In other words, the observation field of view can be moved without changing positional relation between the objective lens of the microscope and the sample.

摘要翻译： 目的是在不改变样品的位置或状态的情况下移动或改变物镜而移动显微镜的观察视场。 根据本发明的显微镜光学系统具有通过反射改变光路的方向并且位于显微镜的物镜与要观察的图像之间的光路中的反射镜。 镜子能够随着反射镜反射面的位置而倾斜。 因此，通过倾斜反射镜来移动观察视场。 换句话说，可以移动观察视场而不改变显微镜的物镜与样本之间的位置关系。

公开(公告)号：US06108803A

公开(公告)日：2000-08-22

申请号：US66339

申请日：1998-04-28

申请人： Ichiro Sase

发明人： Ichiro Sase

IPC分类号： G01R31/28 ,  G11C29/00 ,  G11C29/02 ,  G11C29/18 ,  G11C29/20

CPC分类号： G11C29/18 ,  G11C29/20

摘要： A memory circuit, provided with address signal generating arrangement that includes first counter 72 for outputting first output data Q1 sequentially designating address signals for memory cells under test in a memory 10, a second counter 74 for outputting second output data Q2 used to designate address signals for each memory cell of the memory 10 for every cell under test, an output control circuit 76 for selectively outputting the second output data Q2 as third output data Q3 depending on a control signal INH, and a computing circuit 78 for carrying out computations based on the first output data Q1 and the third output data Q3, and generating address signals Q4. In this way, a memory receives address signals based on a test pattern, and a tester exclusively for memory tests is not required.

摘要翻译： PCT No.PCT / JP97 / 02565 Sec。 371日期：1998年4月28日 102（e）1998年4月28日PCT PCT 1997年7月24日PCT公布。 第WO98 / 12705号公报 日期1998年3月26日具有地址信号生成装置的存储电路，包括：第一计数器72，用于输出第一输出数据Q1，顺序地指定存储器10中的被测试存储单元的地址信号;第二计数器74，用于输出第二输出数据Q2 用于为每个待测单元的存储器10的每个存储单元指定地址信号;输出控制电路76，用于根据控制信号INH有选择地将第二输出数据Q2输出为第三输出数据Q3;以及计算电路78，用于 基于第一输出数据Q1和第三输出数据Q3进行计算，并产生地址信号Q4。 以这种方式，存储器基于测试模式接收地址信号，并且不需要专门用于存储器测试的测试器。

公开(公告)号：US4675868A

公开(公告)日：1987-06-23

申请号：US716044

申请日：1985-03-26

申请人： Hirohisa Shishikura ,  Ichiro Sase ,  Akio Yanagimachi ,  Osamu Yamada

发明人： Hirohisa Shishikura ,  Ichiro Sase ,  Akio Yanagimachi ,  Osamu Yamada

IPC分类号： H03M13/43 ,  H04N7/035 ,  G06F11/10

CPC分类号： H04N7/0357 ,  H03M13/43

摘要： An error correction system for a difference set cyclic (272,190) code with 190 data bits and 82 test bits in a coded transmission teletext system which transmits character information on the vertical blanking interval of a television signal has been improved in peripheral circuits for operating an error correction circuit. A first improvement is to correct only designated packets which are in frame synchronization condition and/or designated by an index register. A second improvement is to handle shortened (L,k) code where L is less than 272, using common hardware. A third improvement is selection of three operational modes of data to be corrected. In the first mode, uncorrected data is supplied by an external circuit, and said uncorrected data is stored temporarily in a buffer memory, and corrected data is stored in said buffer memory again to supply external circuit corrected data. Transfer of data between the buffer memory and the error correction circuit is handled by wired logic hardware apparatus. In a second mode, uncorrected data and corrected data are provided in a buffer memory but no external circuit is concerned in operation of the present system. In a third mode, no buffer memory is used, and an external circuit supplies uncorrected data to an error correction circuit directly and receives corrected data directly from the error correction circuit.

摘要翻译： 在用于在电视信号的垂直消隐间隔上发送字符信息的编码的传输图文电视系统中具有190个数据位和82个测试位的差分循环（272,190）码的纠错系统已被改进，用于操作错误 校正电路。 第一改进是仅校正处于帧同步状态的指定分组和/或由索引寄存器指定的分组。 第二个改进是使用通用硬件来处理L小于272的缩短（L，k）码。 第三个改进是选择要纠正的三种数据操作模式。 在第一模式中，未校正的数据由外部电路提供，并且所述未校正的数据被临时存储在缓冲存储器中，并且校正的数据被再次存储在所述缓冲存储器中以提供外部电路校正的数据。 缓冲存储器和纠错电路之间的数据传输由有线逻辑硬件设备来处理。 在第二模式中，未校正的数据和校正数据被提供在缓冲存储器中，但是在本系统的操作中没有外部电路。 在第三模式中，不使用缓冲存储器，并且外部电路将未校正的数据直接提供给纠错电路，并直接从纠错电路接收校正数据。

公开(公告)号：US08507261B2

公开(公告)日：2013-08-13

申请号：US12626909

申请日：2009-11-29

申请人： Yasushi Ogihara ,  Ichiro Sase ,  Roman Zantl

发明人： Yasushi Ogihara ,  Ichiro Sase ,  Roman Zantl

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： C12M23/34 ,  C12M23/10 ,  C12M23/22 ,  C12M23/38

摘要： A laboratory dish comprises an incubation container, containing cultured cells, for observation through a microscope, in which a partitioning member partitions an interior of the incubation container into a plurality of incubation chambers by substantially perpendicular walls. The partitioning member tightly fits to a bottom portion of the incubation container, thereby capable of retaining in separation a liquid inputted in each of the incubation chambers from liquids in the other incubation chambers. A cover member covers an upper portion of each of the incubation chambers partitioned by the partitioning member and tightly fitted to the partitioning member. A whole or part of the cover member is formed of a transparent member, and the upper portion of each incubation chamber is formed with an opening via which to input the liquid.

摘要翻译： 实验室皿包括培养容器，其中含有培养的细胞，用于通过显微镜观察，其中分隔构件通过基本垂直的壁将培养容器的内部分隔成多个孵育室。 分隔构件紧密地配合到培养容器的底部，从而能够分离地将输入每个培养室中的液体与其它孵育室中的液体分离。 盖构件覆盖由分隔构件分隔并且紧密地配合到分隔构件的每个孵育室的上部。 盖构件的整体或一部分由透明构件形成，并且每个孵育室的上部形成有用于输入液体的开口。

公开(公告)号：US07957057B2

公开(公告)日：2011-06-07

申请号：US12536408

申请日：2009-08-05

申请人： Ichiro Sase ,  Katsuya Watanabe

发明人： Ichiro Sase ,  Katsuya Watanabe

IPC分类号： G02B21/00

CPC分类号： G02B21/32 ,  G02B21/002

摘要： An observation field of view of a microscope can be moved without moving or changing an objective lens and without varying position or state of a sample. A microscope optical system has a mirror that changes the direction of the optical path by reflection and is located in the optical path between an objective lens of the microscope and an image to be observed. The mirror is able to be tilted by changing the position of a reflecting surface of the mirror. Accordingly, the observation field of view is moved by tilting the mirror. In other words, the observation field of view can be moved without changing a positional relationship between the objective lens of the microscope and the sample.

摘要翻译： 可以移动显微镜的观察视场而不移动或改变物镜，而不改变样品的位置或状态。 显微镜光学系统具有通过反射改变光路的方向并且位于显微镜的物镜与要观察的图像之间的光路中的反射镜。 镜子能够通过改变镜子的反射面的位置来倾斜。 因此，通过倾斜反射镜来移动观察视场。 换句话说，可以移动观察视场而不改变显微镜的物镜与样本之间的位置关系。

公开(公告)号：US07864414B2

公开(公告)日：2011-01-04

申请号：US12409869

申请日：2009-03-24

申请人： Ichiro Sase ,  Shuji Toyoda

发明人： Ichiro Sase ,  Shuji Toyoda

IPC分类号： G02B21/00

CPC分类号： G02B21/367 ,  G02B21/002 ,  G02B21/06

摘要： Providing a microscope capable of movably adjusting an observation field of a sample without moving the sample. The microscope includes a first objective lens, a second objective lens, a mirror, an angular adjustment mechanism, and a shift mechanism. The first objective lens is disposed to the sample side. The second objective lens forms an intermediate image of the sample together with the first objective lens. The mirror is disposed with a tilt on an optical path between the first objective lens and the second objective lens. The angular adjustment mechanism rotatably adjust the mirror in the tilt direction. The shift mechanism makes a shift adjustment of the second objective lens in an axial direction of a rotation axis of the mirror. With the configuration, the observation field can be moved two-dimensionally by the angular adjustment mechanism.

摘要翻译： 提供能够可移动地调整样品的观察场而不移动样品的显微镜。 显微镜包括第一物镜，第二物镜，反射镜，角度调节机构和移位机构。 第一物镜设置在样品侧。 第二物镜与第一物镜一起形成样品的中间图像。 反射镜在第一物镜和第二物镜之间的光路上倾斜地配置。 角度调节机构可以在倾斜方向上可旋转地调节反射镜。 换档机构使第二物镜在反射镜的旋转轴的轴向上进行偏移调整。 利用该构造，可以通过角度调节机构二维地移动观察场。

公开(公告)号：US07630113B2

公开(公告)日：2009-12-08

申请号：US11121961

申请日：2005-05-05

申请人： Ichiro Sase ,  Katsuya Watanabe

发明人： Ichiro Sase ,  Katsuya Watanabe

IPC分类号： G02B26/08

CPC分类号： G02B21/32 ,  G02B21/002

摘要： An observation field of view of a microscope can be moved without moving or changing an objective lens and without varying position or state of a sample. A microscope optical system has a mirror that changes the direction of the optical path by reflection. The mirror is located in the optical path between an objective lens of the microscope and an image to be observed. The mirror can be tilted to change the position of a reflecting surface of the mirror. Accordingly, the observation field of view is moved by tilting the mirror without changing a positional relation between the objective lens of the microscope and the sample.

摘要翻译： 可以移动显微镜的观察视场而不移动或改变物镜，而不改变样品的位置或状态。 显微镜光学系统具有通过反射改变光路的方向的反射镜。 镜子位于显微镜的物镜和待观察的图像之间的光路中。 镜子可以倾斜以改变反射镜的反射表面的位置。 因此，通过在不改变显微镜的物镜与样本之间的位置关系的情况下倾斜镜子来移动观察视场。