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公开(公告)号：US07863243B2
公开(公告)日：2011-01-04
申请号：US11414100
申请日：2006-04-28
申请人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
发明人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
IPC分类号： A61K38/00
CPC分类号： A61K38/2264
摘要： The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic method against a tumor using adiponectin. The administration form may be either oral administration, e.g., by tablets or parenteral administration, e.g., by injection; in the case of intravenous injection for inhibiting carcinogenesis in the liver, the dosage is 1 to 100 mg/kg/day per adult patient.
摘要翻译： 本发明提供了含有脂联素作为活性成分的新抗肿瘤剂，特别是能够抑制肝脏致癌作用的抗肿瘤剂，使用脂联素作为抗肿瘤剂，以及用于预防或治疗方法 使用脂联素的肿瘤。 给药形式可以是口服给药，例如通过片剂或肠胃外给药，例如通过注射; 在静脉注射用于抑制肝脏致癌作用的情况下，每位成年患者的剂量为1至100mg / kg /天。
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公开(公告)号：US07375189B2
公开(公告)日：2008-05-20
申请号：US11371104
申请日：2006-03-09
申请人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
发明人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
CPC分类号： A61K38/2264
摘要： Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflammatory effect, its action on hepatic stellate cells has never been known hitherto. The present invention has elucidated that adiponectin inhibits the actions of TGFB and PDGF on hepatic stellate cells and thereby exerts effects of suppressing hepatic fibrosis and promoting the proliferation of normal hepatocytes.
摘要翻译： 虽然已知脂肪特异性蛋白质的脂联素具有抑制血管平滑肌的增殖和迁移，对动脉硬化的作用，抑制单核细胞和巨噬细胞活化的作用和抗炎作用的作用， 迄今为止从未知晓对肝星状细胞的作用。 本发明阐明脂联素抑制TGFB和PDGF对肝星状细胞的作用，从而发挥抑制肝纤维化和促进正常肝细胞增殖的作用。
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公开(公告)号：US20060247169A1
公开(公告)日：2006-11-02
申请号：US11414100
申请日：2006-04-28
申请人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
发明人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
IPC分类号： A61K38/17
CPC分类号： A61K38/2264
摘要： The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic method against a tumor using adiponectin. The administration form may be either oral administration, e.g., by tablets or parenteral administration, e.g., by injection; in the case of intravenous injection for inhibiting carcinogenesis in the liver, the dosage is 1 to 100 mg/kg/day per adult patient.
摘要翻译： 本发明提供了含有脂联素作为活性成分的新抗肿瘤剂，特别是能够抑制肝脏致癌作用的抗肿瘤剂，使用脂联素作为抗肿瘤剂，以及用于预防或治疗方法 使用脂联素的肿瘤。 给药形式可以是口服给药，例如通过片剂或肠胃外给药，例如通过注射; 在静脉注射用于抑制肝脏致癌作用的情况下，每位成年患者的剂量为1至100mg / kg /天。
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公开(公告)号：US07074756B2
公开(公告)日：2006-07-11
申请号：US10479581
申请日：2002-06-05
申请人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
发明人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
IPC分类号： A61K38/00
CPC分类号： A61K38/2264
摘要： Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflammatory effect, its action on hepatic stellate cells has never been known hitherto. The present invention has elucidated that adiponectin inhibits the actions of TGFB and PDGF on hepatic stellate cells and thereby exerts effects of suppressing hepatic fibrosis and promoting the proliferation of normal hepatocytes.
摘要翻译： 虽然已知脂肪特异性蛋白质的脂联素具有抑制血管平滑肌的增殖和迁移，对动脉硬化的作用，抑制单核细胞和巨噬细胞活化的作用和抗炎作用的作用， 迄今为止从未知晓对肝星状细胞的作用。 本发明阐明脂联素抑制TGFB和PDGF对肝星状细胞的作用，从而发挥抑制肝纤维化和促进正常肝细胞增殖的作用。
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公开(公告)号：US20060154869A1
公开(公告)日：2006-07-13
申请号：US11371104
申请日：2006-03-09
申请人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
发明人： Yuji Matsuzawa , Tohru Funahashi , Shinji Tamura
IPC分类号： A61K38/17
CPC分类号： A61K38/2264
摘要： Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflammatory effect, its action on hepatic stellate cells has never been known hitherto. The present invention has elucidated that adiponectin inhibits the actions of TGFB and PDGF on hepatic stellate cells and thereby exerts effects of suppressing hepatic fibrosis and promoting the proliferation of normal hepatocytes.
摘要翻译： 虽然已知脂肪特异性蛋白质的脂联素具有抑制血管平滑肌的增殖和迁移，对动脉硬化的作用，抑制单核细胞和巨噬细胞活化的作用和抗炎作用的作用， 迄今为止从未知晓对肝星状细胞的作用。 本发明阐明脂联素抑制TGFB和PDGF对肝星状细胞的作用，从而发挥抑制肝纤维化和促进正常肝细胞增殖的作用。
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公开(公告)号：US20090203608A1
公开(公告)日：2009-08-13
申请号：US12371525
申请日：2009-02-13
摘要： The present invention provides a novel secretory/membrane protein associated with adipocyte differentiation and/or metabolism function, specifically, an adipocyte-derived secretory/membrane protein containing amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 or 22, a nucleic acid encoding it, an antibody therefor, a method of screening prophylactic and/or therapeutic agents for diseases involving abnormality of adipocyte differentiation/metabolism function using it and/or a kit for the screening, a prophylactic and/or therapeutic agent for the diseases or a diagnostic agent containing the membrane protein.
摘要翻译： 本发明提供了与脂肪细胞分化和/或代谢功能相关的新型分泌/膜蛋白，具体地，含有脂肪细胞的分泌/膜蛋白的氨基酸序列与SEQ ID NO：1所示的氨基酸序列相同或基本上相同 2号，4号，6号，8号，10号，14号，16号，18号，20号，12号，14号，18号，20号或22号，编码它的核酸，其抗体，筛选涉及异常的疾病的预防和/或治疗剂的方法 使用其的脂肪细胞分化/代谢功能和/或用于筛选的试剂盒，用于疾病的预防和/或治疗剂或含有所述膜蛋白的诊断剂。
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公开(公告)号：US09345671B2
公开(公告)日：2016-05-24
申请号：US10555076
申请日：2004-04-27
IPC分类号： A61K31/047 , A61K31/10 , A61K31/191 , A61K31/21 , A61K31/22 , A61K31/495 , A61K31/505 , A61K31/00 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47
CPC分类号： A61K31/00 , A61K31/047 , A61K31/10 , A61K31/191 , A61K31/21 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/495 , A61K31/505
摘要： The present invention provides a pharmaceutical composition for enhancement of adiponectin production, treatment or prevention of hypoadiponectinemia, and the like, comprising as an active ingredient an HMG-CoA reductase inhibitor.
摘要翻译： 本发明提供一种用于增强脂联素产生，治疗或预防低脂联素血症的药物组合物等，其包含HMG-CoA还原酶抑制剂作为活性成分。
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公开(公告)号：US20060084618A1
公开(公告)日：2006-04-20
申请号：US10540864
申请日：2003-12-25
CPC分类号： C12N15/85 , C07K14/4702 , C12N2830/001 , C12N2830/008 , C12N2830/85 , G01N33/74
摘要： The present invention relates to a DNA having a promoter region containing regulatory sequences of human adiponectin gene, transformants transformed with the DNA, a screening method of a compound which can enhance the human adiponectin promoter activity, which the transformants are used, and the screening kit, and a screening method of a preventive/therapeutic medicine for syndromes such as Syndrome X, metabolic syndrome, multiple risk factor syndrome, insulin resistant syndrome, deadly quartet, and visceral fat syndrome, metabolic disorders such as diabetes, obesity, hypercholesterolemia, and hyperlipoproteinemias, hyperlipidemia, arteriosclerosis, hypertonia, circulatory system disease, and hyperphagia and a pharmaceutical composition obtained by using them.
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公开(公告)号：US07833972B2
公开(公告)日：2010-11-16
申请号：US12371525
申请日：2009-02-13
摘要： A method of suppressing the differentiation of an adipocite and/or lipid accumulation in an adipocyte, which comprises contacting the adipocyte with a protein comprising the amino acid sequence of SEQ ID NO: 2 or a salt thereof, or with a polynucleotide comprising a sense strand sequence encoding a protein comprising the amino acid sequence of SEQ ID NO: 2.
摘要翻译： 一种抑制脂肪细胞中脂肪和/或脂肪积累分化的方法，其包括将脂肪细胞与包含SEQ ID NO：2的氨基酸序列或其盐的蛋白质或与包含有义链的多核苷酸接触 编码包含SEQ ID NO：2的氨基酸序列的蛋白质的序列。
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公开(公告)号：US07585623B2
公开(公告)日：2009-09-08
申请号：US10540864
申请日：2003-12-25
CPC分类号： C12N15/85 , C07K14/4702 , C12N2830/001 , C12N2830/008 , C12N2830/85 , G01N33/74
摘要： The present invention relates to a DNA having a promoter region containing regulatory sequences of human adiponectin gene, transformants transformed with the DNA, a screening method of a compound which can enhance the human adiponectin promoter activity, which the transformants are used, and the screening kit, and a screening method of a preventive/therapeutic medicine for syndromes such as Syndrome X, metabolic syndrome, multiple risk factor syndrome, insulin resistant syndrome, deadly quartet, and visceral fat syndrome, metabolic disorders such as diabetes, obesity, hypercholesterolemia, and hyperlipoproteinemias, hyperlipidemia, arteriosclerosis, hypertonia, circulatory system disease, and hyperphagia and a pharmaceutical composition obtained by using them.
摘要翻译： 本发明涉及具有包含人脂连蛋白基因调控序列的启动子区域的DNA，用DNA转化的转化体，能够增强人类脂联素启动子活性的化合物的筛选方法，以及筛选试剂盒 ，综合征X，代谢综合征，多发危险因素综合征，胰岛素抵抗综合征，致命四重奏和内脏脂肪综合征等综合征的预防/治疗药物的筛选方法，糖尿病，肥胖症，高胆固醇血症和高脂蛋白血症等代谢性疾病 ，高脂血症，动脉硬化，高渗，循环系统疾病和食欲过盛以及通过使用它们获得的药物组合物。
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