公开(公告)号：US20070202156A1

公开(公告)日：2007-08-30

申请号：US11705027

申请日：2007-02-12

申请人： Yuji Saeki ,  Masato Nishimura ,  Christopher Adams ,  Steven Sanders

发明人： Yuji Saeki ,  Masato Nishimura ,  Christopher Adams ,  Steven Sanders

IPC分类号： A61K9/70

CPC分类号： A61K9/7053 ,  A61K9/7084 ,  A61K31/4468

摘要： The present invention provides percutaneously absorbable adhesive preparations and transdermal compositions comprising Sufentanil, which are obtained from economic starting materials, have a constitution simpler than that of conventional Sufentanil adhesive preparations, and have effective skin permeability. The preparations and compositions comprise two polyisobutylenes having different molecular weights, a tackifier, a permeation enhancer.

摘要翻译： 本发明提供了经济可吸收的粘合剂制剂和由经济起始材料得到的包含舒芬太尼的透皮组合物，其结构比常规舒芬太尼粘合剂制剂简单，具有有效的皮肤渗透性。 制剂和组合物包含两种具有不同分子量的聚异丁烯，增粘剂，渗透促进剂。

公开(公告)号：US08394404B2

公开(公告)日：2013-03-12

申请号：US11196936

申请日：2005-08-04

申请人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

发明人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

IPC分类号： A61L15/16 ,  C08F136/00

CPC分类号： A61K9/7053

摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.

摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至1​​0×10 4 Pa·s，并且包含 两种具有不同流动性的合成橡胶。

公开(公告)号：US08591939B2

公开(公告)日：2013-11-26

申请号：US11196935

申请日：2005-08-04

申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

IPC分类号： A61K31/445 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/4468

摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。

公开(公告)号：US20060034900A1

公开(公告)日：2006-02-16

申请号：US11196935

申请日：2005-08-04

申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

IPC分类号： A61K31/445 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/4468

摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

公开(公告)号：US20060034901A1

公开(公告)日：2006-02-16

申请号：US11196936

申请日：2005-08-04

申请人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

发明人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

IPC分类号： A61L15/16 ,  C08F136/00

CPC分类号： A61K9/7053

摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.

摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至1​​0×10 6 包括两种具有不同流动性的合成橡胶。

公开(公告)号：US20090264806A1

公开(公告)日：2009-10-22

申请号：US12423900

申请日：2009-04-15

申请人： Kei Tamura ,  Keigo Inosaka ,  Yuji Saeki

发明人： Kei Tamura ,  Keigo Inosaka ,  Yuji Saeki

IPC分类号： A61F13/02 ,  A61K9/70

CPC分类号： A61K31/565 ,  A61K9/7053 ,  A61K9/7092

摘要： The present invention provides a transdermal drug administration device capable of freely controlling release of the drug. The transdermal drug administration device of the present invention contains a backing layer and a matrix layer provided on at least one surface of the backing layer, wherein the matrix layer contains a region located on a proximal side from the backing layer and a region located on a distal side from the backing layer, and the water-absorbing polymers therein have different weight concentrations, which enables high control of a drug released from the device.

摘要翻译： 本发明提供能够自由地控制药物释放的透皮给药装置。 本发明的透皮给药装置包含背衬层和设置在背衬层的至少一个表面上的基质层，其中基质层包含位于背衬层近侧的区域和位于背衬层上的区域 远离背衬层的侧面，并且其中的吸水聚合物具有不同的重量浓度，这使得能够高度控制从该装置释放的药物。

公开(公告)号：US08758312B2

公开(公告)日：2014-06-24

申请号：US13542994

申请日：2012-07-06

申请人： Masahiro Mitsushima ,  Hidetoshi Kuroda ,  Yuji Saeki ,  Tomohito Takita

发明人： Masahiro Mitsushima ,  Hidetoshi Kuroda ,  Yuji Saeki ,  Tomohito Takita

IPC分类号： B32B15/04 ,  A61K6/00

CPC分类号： A61K9/7061

摘要： The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability and in anchoring property of its drug-containing pressure-sensitive adhesive layer, and has a preferred patch feeling. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester nonwoven fabric layer.

摘要翻译： 本发明提供一种具有极低的透湿性，足够的ODT效果，药物释放性和药物含粘合剂层的锚定性优异的贴片制剂，并且具有优选的贴片感。 本发明的贴片制剂包括支持体; 以及在载体的一个表面上含有粘着性聚合物和药物的粘合剂层，其中：所述载体具有所述顺序的聚酯基层，无机氧化物层和聚酯无纺布层; 聚酯基层的厚度为1.0μm〜16μm; 并且将压敏粘合剂层层压在聚酯无纺布层上。

公开(公告)号：US20110200663A1

公开(公告)日：2011-08-18

申请号：US12656699

申请日：2010-02-12

申请人： Takumi Hara ,  Kei Tamura ,  Keigo Inosaka ,  Yuji Saeki

发明人： Takumi Hara ,  Kei Tamura ,  Keigo Inosaka ,  Yuji Saeki

IPC分类号： A61K9/70 ,  A61K31/445

CPC分类号： A61K9/7053 ,  A61K31/445 ,  A61K31/4458

摘要： Provided is a methylphenidate patch preparation superior in the stability of a drug (methylphenidate and/or a salt thereof) in the patch preparation, skin permeability of a drug during use of the patch preparation, and methylphenidate availability. A patch preparation having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains methylphenidate and/or a salt thereof, polyisobutylene and a liquid plasticizer. The liquid plasticizer preferably has an HLB value of 1.0-3.3.

摘要翻译： 本发明提供了贴剂制剂中药物（哌甲酯和/或其盐）的稳定性优异的哌甲酯贴片制剂，贴剂制剂使用期间药物的皮肤渗透性和哌甲酯可用性。 一种贴片制剂，其具有形成在所述载体的至少一个表面上的载体和粘合剂层，其中所述粘合剂层含有哌甲酯和/或其盐，聚异丁烯和液体增塑剂。 液体增塑剂的HLB值优选为1.0-3.3。

公开(公告)号：US20110161644A1

公开(公告)日：2011-06-30

申请号：US12676600

申请日：2009-02-26

申请人： Tohru Nojiri ,  Keisuke Toyama ,  Yoshiko Nagasaka ,  Yuji Saeki

发明人： Tohru Nojiri ,  Keisuke Toyama ,  Yoshiko Nagasaka ,  Yuji Saeki

IPC分类号： G06F9/06

CPC分类号： G06F9/5077 ,  G06F9/5016 ,  G06F9/544

摘要： When a plurality of OSs are mounted, it is desirable to efficiently use memory resources without affecting other OSs. Also, even if the OSs are different from each other, they are mounted on one system, and therefore, inter-OS communication is required. In this case, data communication without affecting other OSs is required. Accordingly, an information processor includes: a firmware for assigning a first central processing unit, a first operating system, and a first region being a partial region of a memory as a first domain, assigning a second central processing unit, a second operating system, and a second region being a partial region of the memory as a second domain, and controlling to disable an access of one domain to a region assigned for the other domain; and a middleware for controlling a communication when the data communication is required between the first domain and the second domain. Further, when a sharable code is available in the operating systems, the code is stored in a region of the memory to which only a read access of each domain is enabled. Still further, when the communication is executed between the domains, with a state that the access to the memory region for the communication is limited by the middleware and the firmware, each domain accesses the region.

摘要翻译： 当安装多个OS时，期望有效地使用存储器资源而不影响其他OS。 此外，即使OS彼此不同，它们被安装在一个系统上，因此需要OS之间的通信。 在这种情况下，需要不影响其他操作系统的数据通信。 因此，信息处理器包括：用于分配第一中央处理单元，第一操作系统和作为第一域的存储器的部分区域的第一区域的固件，分配第二中央处理单元，第二操作系统， 并且第二区域是作为第二域的存储器的部分区域，并且控制禁止一个域到分配给另一个域的区域的访问; 以及用于在第一域和第二域之间需要数据通信时控制通信的中间件。 此外，当在操作系统中可用的代码可用时，代码被存储在只有每个域的读取访问被启用的存储器的区域中。 此外，当在域之间执行通信时，具有对通信的存储区域的访问受到中间件和固件的限制的状态，每个域访问该区域。

公开(公告)号：US5822605A

公开(公告)日：1998-10-13

申请号：US408561

申请日：1995-03-22

申请人： Tatsuo Higuchi ,  Tadaaki Isobe ,  Junji Nakagoshi ,  Shigeo Takeuchi ,  Tatsuru Toba ,  Yoshiko Yasuda ,  Teruo Tanaka ,  Takayuki Nakagawa ,  Yuji Saeki

发明人： Tatsuo Higuchi ,  Tadaaki Isobe ,  Junji Nakagoshi ,  Shigeo Takeuchi ,  Tatsuru Toba ,  Yoshiko Yasuda ,  Teruo Tanaka ,  Takayuki Nakagawa ,  Yuji Saeki

IPC分类号： G06F15/173 ,  H04L12/56 ,  G06F13/00 ,  H04L12/50

CPC分类号： H04L45/06 ,  G06F15/17381

摘要： In a parallel processor system comprising a plurality of processor elements constituting a network, a source processor element wishing to broadcast data to a plurality of destination processor elements sends a broadcast request message containing the target data to a broadcast exchanger. The broadcast exchanger converts the received message into a broadcast message and sends it over the network to the destinations. A plurality of broadcast request messages, if transmitted parallelly to the broadcast exchanger, are serialized thereby so that only one broadcast message will be transmitted at a time over the network. This prevents deadlock from occurring between different broadcast messages. The routes for transmitting broadcast request messages and those for transmitting broadcast messages are arranged so as not to overlap with one another. This suppresses deadlock between any broadcast request message and broadcast message. The broadcast exchanger is replaced alternatively with one of the partial networks. These schemes all apply where long messages are transmitted through worm-hole routing.

摘要翻译： 在包括构成网络的多个处理器元件的并行处理器系统中，希望向多个目的地处理器元件广播数据的源处理器元件向广播交换机发送包含目标数据的广播请求消息。 广播交换机将接收的消息转换成广播消息，并通过网络将其发送到目的地。 如果与广播交换机并行发送的多个广播请求消息被序列化，从而在网络上一次只能发送一个广播消息。 这可以防止不同广播消息之间发生死锁。 用于发送广播请求消息的路由和用于发送广播消息的路由被布置为不彼此重叠。 这抑制了任何广播请求消息和广播消息之间的死锁。 广播交换机被替换为部分网络之一。 这些方案都适用于通过蠕虫孔路由传输长消息的情况。