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    Adhesive preparation containing fentanyl
    1.
    发明授权
    Adhesive preparation containing fentanyl 有权
    含芬太尼的粘合剂

    公开(公告)号：US08591939B2

    公开(公告)日：2013-11-26

    申请号：US11196935

    申请日：2005-08-04

    申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    IPC分类号： A61K31/445 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K31/4468

    摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

    摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。

    Adhesive material and adhesive preparation
    3.
    发明授权
    Adhesive material and adhesive preparation 有权
    胶粘材料和粘合剂制备

    公开(公告)号：US08394404B2

    公开(公告)日：2013-03-12

    申请号：US11196936

    申请日：2005-08-04

    申请人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

    发明人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

    IPC分类号： A61L15/16 ,  C08F136/00

    CPC分类号： A61K9/7053

    摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.

    摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至1​​0×10 4 Pa·s，并且包含 两种具有不同流动性的合成橡胶。

    Adhesive material and adhesive preparation
    4.
    发明申请
    Adhesive material and adhesive preparation 有权
    胶粘材料和粘合剂制备

    公开(公告)号：US20060034901A1

    公开(公告)日：2006-02-16

    申请号：US11196936

    申请日：2005-08-04

    申请人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

    发明人： Hitoshi Akemi ,  Kazuhisa Ninomiya ,  Hidetoshi Kuroda ,  Kensuke Matsuoka ,  Yuji Saeki ,  Masato Nishimura

    IPC分类号： A61L15/16 ,  C08F136/00

    CPC分类号： A61K9/7053

    摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.

    摘要翻译： 本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许 当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至1​​0×10 6 包括两种具有不同流动性的合成橡胶。

    Patch and production method thereof
    5.
    发明授权
    Patch and production method thereof 失效
    补片及其制作方法

    公开(公告)号：US07964213B2

    公开(公告)日：2011-06-21

    申请号：US10411822

    申请日：2003-04-11

    申请人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano

    发明人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano

    IPC分类号： A61F13/00

    CPC分类号： A61K9/7061 ,  Y10T442/2738 ,  Y10T442/674

    摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.

    摘要翻译： 本发明涉及含有基材，含有层叠在基材的一个表面上的药物的非交联粘合剂层（A）和层压在粘合剂层（A）上的交联粘合剂层（B））的贴剂。 根据本发明，可以提高药物的经皮吸收性，并且可以提供没有诸如粘合剂残留和粘合剂渗色的问题的贴剂。

    Nicotine transdermal preparation and production method thereof
    7.
    发明授权
    Nicotine transdermal preparation and production method thereof 失效
    尼古丁透皮制剂及其制备方法

    公开(公告)号：US08506991B2

    公开(公告)日：2013-08-13

    申请号：US11546302

    申请日：2006-10-12

    申请人： Shiro Satoda ,  Kazuhisa Ninomiya ,  Junichi Saito ,  Kensuke Matsuoka ,  Shunetsu Kikuchi

    发明人： Shiro Satoda ,  Kazuhisa Ninomiya ,  Junichi Saito ,  Kensuke Matsuoka ,  Shunetsu Kikuchi

    IPC分类号： A61L15/16 ,  A61K9/70 ,  A61K31/465 ,  A61K47/14

    CPC分类号： A61K9/7061 ,  A61K31/465 ,  A61K47/14

    摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off.The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.

    摘要翻译： 本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感， 与剥离时的皮肤刺激性降低，粘合性优异。 本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。 本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角 含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂 包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

    Nicotine transdermal preparation and production method thereof
    8.
    发明申请
    Nicotine transdermal preparation and production method thereof 失效
    尼古丁透皮制剂及其制备方法

    公开(公告)号：US20070087043A1

    公开(公告)日：2007-04-19

    申请号：US11546302

    申请日：2006-10-12

    申请人： Shiro Satoda ,  Kazuhisa Ninomiya ,  Junichi Saito ,  Kensuke Matsuoka ,  Shunetsu Kikuchi

    发明人： Shiro Satoda ,  Kazuhisa Ninomiya ,  Junichi Saito ,  Kensuke Matsuoka ,  Shunetsu Kikuchi

    IPC分类号： A61K31/4439 ,  A61K9/70

    CPC分类号： A61K9/7061 ,  A61K31/465 ,  A61K47/14

    摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off. The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.

    摘要翻译： 本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感， 与剥离时的皮肤刺激性降低，粘合性优异。 本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。 本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角 含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂 包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

    PATCH PREPARATION AND PRODUCTION METHOD THEREOF
    10.
    发明申请
    PATCH PREPARATION AND PRODUCTION METHOD THEREOF 审中-公开
    PATCH制备及其生产方法

    公开(公告)号：US20110243998A1

    公开(公告)日：2011-10-06

    申请号：US13074911

    申请日：2011-03-29

    申请人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

    发明人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

    IPC分类号： A61K9/00 ,  A61K31/445 ,  A61K31/4174 ,  A61K31/34 ,  A61K31/192 ,  A61K31/195 ,  A61K31/4152 ,  A61K31/46

    CPC分类号： A61K9/7061 ,  A61K9/7053

    摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.

    摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。